Systemic in vitro and in vivo evaluation for determining the feasibility of making an amorphous solid dispersion of a B-Raf (rapidly accelerated fibrosarcoma) inhibitor

•Solubility enhancement predication (about 200 fold) of amorphous form of G–F by using thermal approach.•Making spray-dried amorphous dispersion (SDD) of G–F based on favorable solubility prediction.•In vitro dissolution of G–F SDD shows about 20 fold increase compared with crystalline form.•In vivo...

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