Formation of cofilin-actin rods following cucurbitacin-B-induced actin aggregation depends on slingshot homolog 1-mediated cofilin hyperactivation

ABSTRACT Accumulating evidence indicates that cucurbitacin B (CuB), as well as other cucurbitacins, damages the actin cytoskeleton in a variety of cell types. However, the underlying mechanism of such an effect is not well understood. In this study, we showed that CuB rapidly induced actin aggregati...

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Veröffentlicht in:	Journal of cellular biochemistry 2013-10, Vol.114 (10), p.2415-2429
Hauptverfasser:	Zhang, Yan-Ting, Ouyang, Dong-Yun, Xu, Li-Hui, Zha, Qing-Bing, He, Xian-Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	ACTIN AGGREGATION Actins - metabolism Animals Cell Cycle - drug effects Cell Line Cell Movement - drug effects Cell Proliferation - drug effects COFILIN Cofilin 1 - metabolism COFILIN-ACTIN RODS CUCURBITACIN B Cucurbitacins - pharmacology Humans MELANOMA Mice Microscopy, Fluorescence Phosphoprotein Phosphatases - metabolism Reactive Oxygen Species - metabolism SLINGSHOT HOMOLOG 1
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