Serum HMGB1 as a Diagnostic Marker for Malignant Peritoneal Mesothelioma
BACKGROUND:Diffuse malignant peritoneal mesothelioma (DMPM) is an aggressive malignant tumor of mesothelial origin that shows a limited response to cytoreductive surgery along with intraperitoneal chemotherapy. Therefore, early diagnosis of DMPM is very important. Some researchers have previously re...
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| Veröffentlicht in: | Journal of clinical gastroenterology 2013-09, Vol.47 (8), p.684-688 |
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| container_title | Journal of clinical gastroenterology |
| container_volume | 47 |
| creator | Tabata, Chiharu Kanemura, Shingo Tabata, Rie Masachika, Eriko Shibata, Eisuke Otsuki, Tai-Ichiro Nishizaki, Tomoyuki Nakano, Takashi |
| description | BACKGROUND:Diffuse malignant peritoneal mesothelioma (DMPM) is an aggressive malignant tumor of mesothelial origin that shows a limited response to cytoreductive surgery along with intraperitoneal chemotherapy. Therefore, early diagnosis of DMPM is very important. Some researchers have previously reported that high-mobility group box 1 (HMGB1) was correlated with pulmonary fibrosis. DMPM involves the malignant transformation of mesothelial cells, which originate from mesenchymal cells, similar to lung fibroblasts. Here, we investigated serum levels of HMGB1 in patients with MPM and compared them with those of a population that had been exposed to asbestos without developing MPM.
STUDY:The serum concentrations of HMGB1 were measured in 13 DMPM patients and 45 individuals with benign asbestos-related diseases.
RESULT:We demonstrated that the patients with DMPM had significantly higher serum levels of HMGB1 compared with the population who had been exposed to asbestos but did not develop DMPM.
CONCLUSION:Our data suggest that serum HMGB1 concentration is a useful serum marker for DMPM. |
| doi_str_mv | 10.1097/MCG.0b013e318297fa65 |
| format | Article |
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STUDY:The serum concentrations of HMGB1 were measured in 13 DMPM patients and 45 individuals with benign asbestos-related diseases.
RESULT:We demonstrated that the patients with DMPM had significantly higher serum levels of HMGB1 compared with the population who had been exposed to asbestos but did not develop DMPM.
CONCLUSION:Our data suggest that serum HMGB1 concentration is a useful serum marker for DMPM.</description><identifier>ISSN: 0192-0790</identifier><identifier>EISSN: 1539-2031</identifier><identifier>DOI: 10.1097/MCG.0b013e318297fa65</identifier><identifier>PMID: 23685846</identifier><language>eng</language><publisher>United States: by Lippincott Williams & Wilkins</publisher><subject>Aged ; Asbestos - toxicity ; Asbestosis - blood ; Asbestosis - diagnosis ; Asbestosis - pathology ; Biomarkers, Tumor - blood ; Case-Control Studies ; Female ; HMGB1 Protein - blood ; Humans ; Male ; Mesothelioma - blood ; Mesothelioma - diagnosis ; Mesothelioma - pathology ; Middle Aged ; Peritoneal Neoplasms - blood ; Peritoneal Neoplasms - diagnosis ; Peritoneal Neoplasms - pathology</subject><ispartof>Journal of clinical gastroenterology, 2013-09, Vol.47 (8), p.684-688</ispartof><rights>2013 by Lippincott Williams & Wilkins</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4225-7d7b20190903f105a6690dfeaf550486ef4ac56ca2f1407b037948beadd2b0bf3</citedby><cites>FETCH-LOGICAL-c4225-7d7b20190903f105a6690dfeaf550486ef4ac56ca2f1407b037948beadd2b0bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23685846$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tabata, Chiharu</creatorcontrib><creatorcontrib>Kanemura, Shingo</creatorcontrib><creatorcontrib>Tabata, Rie</creatorcontrib><creatorcontrib>Masachika, Eriko</creatorcontrib><creatorcontrib>Shibata, Eisuke</creatorcontrib><creatorcontrib>Otsuki, Tai-Ichiro</creatorcontrib><creatorcontrib>Nishizaki, Tomoyuki</creatorcontrib><creatorcontrib>Nakano, Takashi</creatorcontrib><title>Serum HMGB1 as a Diagnostic Marker for Malignant Peritoneal Mesothelioma</title><title>Journal of clinical gastroenterology</title><addtitle>J Clin Gastroenterol</addtitle><description>BACKGROUND:Diffuse malignant peritoneal mesothelioma (DMPM) is an aggressive malignant tumor of mesothelial origin that shows a limited response to cytoreductive surgery along with intraperitoneal chemotherapy. Therefore, early diagnosis of DMPM is very important. Some researchers have previously reported that high-mobility group box 1 (HMGB1) was correlated with pulmonary fibrosis. DMPM involves the malignant transformation of mesothelial cells, which originate from mesenchymal cells, similar to lung fibroblasts. Here, we investigated serum levels of HMGB1 in patients with MPM and compared them with those of a population that had been exposed to asbestos without developing MPM.
STUDY:The serum concentrations of HMGB1 were measured in 13 DMPM patients and 45 individuals with benign asbestos-related diseases.
RESULT:We demonstrated that the patients with DMPM had significantly higher serum levels of HMGB1 compared with the population who had been exposed to asbestos but did not develop DMPM.
CONCLUSION:Our data suggest that serum HMGB1 concentration is a useful serum marker for DMPM.</description><subject>Aged</subject><subject>Asbestos - toxicity</subject><subject>Asbestosis - blood</subject><subject>Asbestosis - diagnosis</subject><subject>Asbestosis - pathology</subject><subject>Biomarkers, Tumor - blood</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>HMGB1 Protein - blood</subject><subject>Humans</subject><subject>Male</subject><subject>Mesothelioma - blood</subject><subject>Mesothelioma - diagnosis</subject><subject>Mesothelioma - pathology</subject><subject>Middle Aged</subject><subject>Peritoneal Neoplasms - blood</subject><subject>Peritoneal Neoplasms - diagnosis</subject><subject>Peritoneal Neoplasms - pathology</subject><issn>0192-0790</issn><issn>1539-2031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EoqXwDxDKyJJy_ogTj1CgRSICCZgjJzm3oUlc7EQV_56gFgYGprvhed87PYScU5hSUPFVOptPIQfKkdOEqdhoGR2QMY24ChlwekjGQBULIVYwIifevwPQmHN6TEaMyyRKhByTxQu6vgkW6fyGBtoHOrit9LK1vquKINVujS4w1g1rXS1b3XbBM7qqsy3qOkjR226FdWUbfUqOjK49nu3nhLzd373OFuHj0_xhdv0YFoKxKIzLOGfDX6CAGwqRllJBaVCbKAKRSDRCF5EsNDNUQJwDj5VIctRlyXLIDZ-Qy13vxtmPHn2XNZUvsK51i7b3GRVMAkgl1ICKHVo4671Dk21c1Wj3mVHIvh1mg8Psr8MhdrG_0OcNlr-hH2kDkOyAra07dH5d91t02WpQ0q3-7_4CRpV-kQ</recordid><startdate>201309</startdate><enddate>201309</enddate><creator>Tabata, Chiharu</creator><creator>Kanemura, Shingo</creator><creator>Tabata, Rie</creator><creator>Masachika, Eriko</creator><creator>Shibata, Eisuke</creator><creator>Otsuki, Tai-Ichiro</creator><creator>Nishizaki, Tomoyuki</creator><creator>Nakano, Takashi</creator><general>by Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201309</creationdate><title>Serum HMGB1 as a Diagnostic Marker for Malignant Peritoneal Mesothelioma</title><author>Tabata, Chiharu ; Kanemura, Shingo ; Tabata, Rie ; Masachika, Eriko ; Shibata, Eisuke ; Otsuki, Tai-Ichiro ; Nishizaki, Tomoyuki ; Nakano, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4225-7d7b20190903f105a6690dfeaf550486ef4ac56ca2f1407b037948beadd2b0bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Asbestos - toxicity</topic><topic>Asbestosis - blood</topic><topic>Asbestosis - diagnosis</topic><topic>Asbestosis - pathology</topic><topic>Biomarkers, Tumor - blood</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>HMGB1 Protein - blood</topic><topic>Humans</topic><topic>Male</topic><topic>Mesothelioma - blood</topic><topic>Mesothelioma - diagnosis</topic><topic>Mesothelioma - pathology</topic><topic>Middle Aged</topic><topic>Peritoneal Neoplasms - blood</topic><topic>Peritoneal Neoplasms - diagnosis</topic><topic>Peritoneal Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tabata, Chiharu</creatorcontrib><creatorcontrib>Kanemura, Shingo</creatorcontrib><creatorcontrib>Tabata, Rie</creatorcontrib><creatorcontrib>Masachika, Eriko</creatorcontrib><creatorcontrib>Shibata, Eisuke</creatorcontrib><creatorcontrib>Otsuki, Tai-Ichiro</creatorcontrib><creatorcontrib>Nishizaki, Tomoyuki</creatorcontrib><creatorcontrib>Nakano, Takashi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tabata, Chiharu</au><au>Kanemura, Shingo</au><au>Tabata, Rie</au><au>Masachika, Eriko</au><au>Shibata, Eisuke</au><au>Otsuki, Tai-Ichiro</au><au>Nishizaki, Tomoyuki</au><au>Nakano, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum HMGB1 as a Diagnostic Marker for Malignant Peritoneal Mesothelioma</atitle><jtitle>Journal of clinical gastroenterology</jtitle><addtitle>J Clin Gastroenterol</addtitle><date>2013-09</date><risdate>2013</risdate><volume>47</volume><issue>8</issue><spage>684</spage><epage>688</epage><pages>684-688</pages><issn>0192-0790</issn><eissn>1539-2031</eissn><abstract>BACKGROUND:Diffuse malignant peritoneal mesothelioma (DMPM) is an aggressive malignant tumor of mesothelial origin that shows a limited response to cytoreductive surgery along with intraperitoneal chemotherapy. Therefore, early diagnosis of DMPM is very important. Some researchers have previously reported that high-mobility group box 1 (HMGB1) was correlated with pulmonary fibrosis. DMPM involves the malignant transformation of mesothelial cells, which originate from mesenchymal cells, similar to lung fibroblasts. Here, we investigated serum levels of HMGB1 in patients with MPM and compared them with those of a population that had been exposed to asbestos without developing MPM.
STUDY:The serum concentrations of HMGB1 were measured in 13 DMPM patients and 45 individuals with benign asbestos-related diseases.
RESULT:We demonstrated that the patients with DMPM had significantly higher serum levels of HMGB1 compared with the population who had been exposed to asbestos but did not develop DMPM.
CONCLUSION:Our data suggest that serum HMGB1 concentration is a useful serum marker for DMPM.</abstract><cop>United States</cop><pub>by Lippincott Williams & Wilkins</pub><pmid>23685846</pmid><doi>10.1097/MCG.0b013e318297fa65</doi><tpages>5</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Aged Asbestos - toxicity Asbestosis - blood Asbestosis - diagnosis Asbestosis - pathology Biomarkers, Tumor - blood Case-Control Studies Female HMGB1 Protein - blood Humans Male Mesothelioma - blood Mesothelioma - diagnosis Mesothelioma - pathology Middle Aged Peritoneal Neoplasms - blood Peritoneal Neoplasms - diagnosis Peritoneal Neoplasms - pathology |
| title | Serum HMGB1 as a Diagnostic Marker for Malignant Peritoneal Mesothelioma |
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