Duration of analgesia and pruritus following intrathecal fentanyl for labour analgesia: no significant effect of A118G μ-opioid receptor polymorphism, but a marked effect of ethnically distinct hospital populations

Genetic polymorphism (A118G) in the μ-opioid receptor has been reported to affect systemic opioid analgesia. However, reported pharmacogenetic effects on spinal opioid analgesia, particularly in labour, have been equivocal. We prospectively assessed effects of the μ-opioid receptor A118G single nucl...

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Veröffentlicht in:	British journal of anaesthesia : BJA 2013-09, Vol.111 (3), p.433-444
Hauptverfasser:	Ginosar, Y, Birnbach, D.J., Shirov, T.T., Arheart, K, Caraco, Y, Davidson, E.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult analgesia, obstetric Analgesia, Obstetrical - methods analgesics opioid, fentanyl Analgesics, Opioid - administration & dosage Analgesics, Opioid - adverse effects Analysis of Variance Ethnic Groups - statistics & numerical data Female Fentanyl - administration & dosage Fentanyl - adverse effects Florida - epidemiology genetic factors Humans Injections, Spinal - methods Polymorphism, Genetic - genetics Pregnancy Prospective Studies Pruritus - chemically induced Pruritus - epidemiology Pruritus - genetics Receptors, Opioid, mu - genetics Time Factors Young Adult
Online-Zugang:	Volltext
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