90-Day oral toxicity of ziram: a thyrostatic and hepatotoxic study
Ziram, a dithiocarbamate fungicide, is extensively used in crop protection. Daily oral doses of ziram (5 and 25 mg kg −1 day −1) for 30, 60 and 90 days produced significant mortality in male rats. The fungicide also caused a significant increase in the thyroid:body weight ratio, histological changes...
Gespeichert in:
| Veröffentlicht in: | Environmental pollution (1987) 1990, Vol.65 (4), p.311-322 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 322 |
|---|---|
| container_issue | 4 |
| container_start_page | 311 |
| container_title | Environmental pollution (1987) |
| container_volume | 65 |
| creator | Pandey, Mamta Raizada, R.B. Dikshith, T.S.S. |
| description | Ziram, a dithiocarbamate fungicide, is extensively used in crop protection. Daily oral doses of ziram (5 and 25 mg kg
−1 day
−1) for 30, 60 and 90 days produced significant mortality in male rats. The fungicide also caused a significant increase in the thyroid:body weight ratio, histological changes, and a reduced activity of thyroid
1
25I uptake and protein bound
1
25I. However, the animals did not show any change in the clinical enzyme profile of the liver, serum and brain. It is believed that ETU, the degradation product of ziram and a known antithyroid compound, is the causative agent for the high mortality, as well as for the pronounced thyrostatic and hepatotoxic effects found in the experimental animals. |
| doi_str_mv | 10.1016/0269-7491(90)90123-T |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_14259269</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>026974919090123T</els_id><sourcerecordid>14259269</sourcerecordid><originalsourceid>FETCH-LOGICAL-c509t-e040ca1fa45f41f7309baa5a434028c951873f567c0a4ee2647135c15896f5c53</originalsourceid><addsrcrecordid>eNp90MtOGzEUBmCrKiIh8AZVO5uishg4vs3EXSBRyk1CYkFYWwePXVxNMsF2EMPT10OiZsfKsvSd498_IV8oHFOg1QmwSpW1UPSHgiMFlPFy9omM6bTmZSWY-EzG_8mI7MX4FwAE53yXjKgExZiUY_JLQfkb-6IL2Bape_XGp3xzxZsPOP9ZYJGe-tDFhMmbAhdN8WSXmLp3WsS0avp9suOwjfZgc07Iw-XF7Py6vL27ujk_uy1Nfi2VFgQYpA6FdIK6moN6RJQouAA2NUoOyZ2sagMorGWVqCmXhsqpqpw0kk_I4XrvMnTPKxuTnvtobNviwnarqKlgUuUfZyjW0OTgMVinl8HPMfSagh6600MxeihGK9Dv3elZHvu62b96nNtmO7QpK4PvG4DRYOsCLoyPW6e4UDyHnpBva-ew0_gnZPNwz4ByYDUIIQdxuhY29_XibdDReLswtvHBmqSbzn-c9R-sgZIv</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14259269</pqid></control><display><type>article</type><title>90-Day oral toxicity of ziram: a thyrostatic and hepatotoxic study</title><source>Elsevier ScienceDirect Journals</source><creator>Pandey, Mamta ; Raizada, R.B. ; Dikshith, T.S.S.</creator><creatorcontrib>Pandey, Mamta ; Raizada, R.B. ; Dikshith, T.S.S.</creatorcontrib><description>Ziram, a dithiocarbamate fungicide, is extensively used in crop protection. Daily oral doses of ziram (5 and 25 mg kg
−1 day
−1) for 30, 60 and 90 days produced significant mortality in male rats. The fungicide also caused a significant increase in the thyroid:body weight ratio, histological changes, and a reduced activity of thyroid
1
25I uptake and protein bound
1
25I. However, the animals did not show any change in the clinical enzyme profile of the liver, serum and brain. It is believed that ETU, the degradation product of ziram and a known antithyroid compound, is the causative agent for the high mortality, as well as for the pronounced thyrostatic and hepatotoxic effects found in the experimental animals.</description><identifier>ISSN: 0269-7491</identifier><identifier>EISSN: 1873-6424</identifier><identifier>DOI: 10.1016/0269-7491(90)90123-T</identifier><identifier>PMID: 15092255</identifier><identifier>CODEN: ENVPAF</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Biological and medical sciences ; blood serum ; body weight ; brain ; enzyme activity ; histology ; liver ; Medical sciences ; mortality ; Pesticides, fertilizers and other agrochemicals toxicology ; rats ; thyroid function ; thyroid gland ; toxicity ; Toxicology ; ziram</subject><ispartof>Environmental pollution (1987), 1990, Vol.65 (4), p.311-322</ispartof><rights>1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-e040ca1fa45f41f7309baa5a434028c951873f567c0a4ee2647135c15896f5c53</citedby><cites>FETCH-LOGICAL-c509t-e040ca1fa45f41f7309baa5a434028c951873f567c0a4ee2647135c15896f5c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/026974919090123T$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,4009,27902,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19349371$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15092255$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pandey, Mamta</creatorcontrib><creatorcontrib>Raizada, R.B.</creatorcontrib><creatorcontrib>Dikshith, T.S.S.</creatorcontrib><title>90-Day oral toxicity of ziram: a thyrostatic and hepatotoxic study</title><title>Environmental pollution (1987)</title><addtitle>Environ Pollut</addtitle><description>Ziram, a dithiocarbamate fungicide, is extensively used in crop protection. Daily oral doses of ziram (5 and 25 mg kg
−1 day
−1) for 30, 60 and 90 days produced significant mortality in male rats. The fungicide also caused a significant increase in the thyroid:body weight ratio, histological changes, and a reduced activity of thyroid
1
25I uptake and protein bound
1
25I. However, the animals did not show any change in the clinical enzyme profile of the liver, serum and brain. It is believed that ETU, the degradation product of ziram and a known antithyroid compound, is the causative agent for the high mortality, as well as for the pronounced thyrostatic and hepatotoxic effects found in the experimental animals.</description><subject>Biological and medical sciences</subject><subject>blood serum</subject><subject>body weight</subject><subject>brain</subject><subject>enzyme activity</subject><subject>histology</subject><subject>liver</subject><subject>Medical sciences</subject><subject>mortality</subject><subject>Pesticides, fertilizers and other agrochemicals toxicology</subject><subject>rats</subject><subject>thyroid function</subject><subject>thyroid gland</subject><subject>toxicity</subject><subject>Toxicology</subject><subject>ziram</subject><issn>0269-7491</issn><issn>1873-6424</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><recordid>eNp90MtOGzEUBmCrKiIh8AZVO5uishg4vs3EXSBRyk1CYkFYWwePXVxNMsF2EMPT10OiZsfKsvSd498_IV8oHFOg1QmwSpW1UPSHgiMFlPFy9omM6bTmZSWY-EzG_8mI7MX4FwAE53yXjKgExZiUY_JLQfkb-6IL2Bape_XGp3xzxZsPOP9ZYJGe-tDFhMmbAhdN8WSXmLp3WsS0avp9suOwjfZgc07Iw-XF7Py6vL27ujk_uy1Nfi2VFgQYpA6FdIK6moN6RJQouAA2NUoOyZ2sagMorGWVqCmXhsqpqpw0kk_I4XrvMnTPKxuTnvtobNviwnarqKlgUuUfZyjW0OTgMVinl8HPMfSagh6600MxeihGK9Dv3elZHvu62b96nNtmO7QpK4PvG4DRYOsCLoyPW6e4UDyHnpBva-ew0_gnZPNwz4ByYDUIIQdxuhY29_XibdDReLswtvHBmqSbzn-c9R-sgZIv</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Pandey, Mamta</creator><creator>Raizada, R.B.</creator><creator>Dikshith, T.S.S.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope></search><sort><creationdate>1990</creationdate><title>90-Day oral toxicity of ziram: a thyrostatic and hepatotoxic study</title><author>Pandey, Mamta ; Raizada, R.B. ; Dikshith, T.S.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-e040ca1fa45f41f7309baa5a434028c951873f567c0a4ee2647135c15896f5c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Biological and medical sciences</topic><topic>blood serum</topic><topic>body weight</topic><topic>brain</topic><topic>enzyme activity</topic><topic>histology</topic><topic>liver</topic><topic>Medical sciences</topic><topic>mortality</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>rats</topic><topic>thyroid function</topic><topic>thyroid gland</topic><topic>toxicity</topic><topic>Toxicology</topic><topic>ziram</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pandey, Mamta</creatorcontrib><creatorcontrib>Raizada, R.B.</creatorcontrib><creatorcontrib>Dikshith, T.S.S.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>Environmental pollution (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pandey, Mamta</au><au>Raizada, R.B.</au><au>Dikshith, T.S.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>90-Day oral toxicity of ziram: a thyrostatic and hepatotoxic study</atitle><jtitle>Environmental pollution (1987)</jtitle><addtitle>Environ Pollut</addtitle><date>1990</date><risdate>1990</risdate><volume>65</volume><issue>4</issue><spage>311</spage><epage>322</epage><pages>311-322</pages><issn>0269-7491</issn><eissn>1873-6424</eissn><coden>ENVPAF</coden><abstract>Ziram, a dithiocarbamate fungicide, is extensively used in crop protection. Daily oral doses of ziram (5 and 25 mg kg
−1 day
−1) for 30, 60 and 90 days produced significant mortality in male rats. The fungicide also caused a significant increase in the thyroid:body weight ratio, histological changes, and a reduced activity of thyroid
1
25I uptake and protein bound
1
25I. However, the animals did not show any change in the clinical enzyme profile of the liver, serum and brain. It is believed that ETU, the degradation product of ziram and a known antithyroid compound, is the causative agent for the high mortality, as well as for the pronounced thyrostatic and hepatotoxic effects found in the experimental animals.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>15092255</pmid><doi>10.1016/0269-7491(90)90123-T</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0269-7491 |
| ispartof | Environmental pollution (1987), 1990, Vol.65 (4), p.311-322 |
| issn | 0269-7491 1873-6424 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_14259269 |
| source | Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences blood serum body weight brain enzyme activity histology liver Medical sciences mortality Pesticides, fertilizers and other agrochemicals toxicology rats thyroid function thyroid gland toxicity Toxicology ziram |
| title | 90-Day oral toxicity of ziram: a thyrostatic and hepatotoxic study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T22%3A21%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=90-Day%20oral%20toxicity%20of%20ziram:%20a%20thyrostatic%20and%20hepatotoxic%20study&rft.jtitle=Environmental%20pollution%20(1987)&rft.au=Pandey,%20Mamta&rft.date=1990&rft.volume=65&rft.issue=4&rft.spage=311&rft.epage=322&rft.pages=311-322&rft.issn=0269-7491&rft.eissn=1873-6424&rft.coden=ENVPAF&rft_id=info:doi/10.1016/0269-7491(90)90123-T&rft_dat=%3Cproquest_cross%3E14259269%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14259269&rft_id=info:pmid/15092255&rft_els_id=026974919090123T&rfr_iscdi=true |