Susceptibilities of drugs to nitrosation under simulated gastric conditions

Drugs of differing structures and pharmacological actions have been incubated at 37°C and pH 2.0 under conditions simulating those within the normal fasting stomach. The nitrite concentration (25 μ m) was kept as constant as possible for 3 hr in an attempt to mimic its in vivo replenishment from the...

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Veröffentlicht in:	Food and chemical toxicology 1985-01, Vol.23 (9), p.849-855
Hauptverfasser:	Gillatt, P.N., Palmer, R.C., Smith, P.L.R., Walters, C.L., Reed, P.I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chemical Phenomena Chemistry Drug toxicity and drugs side effects treatment Gastric Juice Humans Hydrogen-Ion Concentration Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Nitrosamines - metabolism Pharmaceutical Preparations - metabolism Pharmacology. Drug treatments
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