Synthesis of a Single G‑Quartet Platform in Water

For over 50 years the G-quartet has been a defining self-assembled structure in biology and non-covalent synthesis. It is shown here for the first time that the G-quartet is isolatable in water in the absence of stabilizing G-quartet stacking or cations through the construction of a phosphate-linked...

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Veröffentlicht in:	Journal of the American Chemical Society 2013-08, Vol.135 (32), p.11985-11989
Hauptverfasser:	Bare, Grant A. L, Liu, Bo, Sherman, John C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridines - pharmacology Anthraquinones - pharmacology Antineoplastic Agents - pharmacology Carbazoles - pharmacology DNA - chemistry DNA - metabolism G-Quadruplexes - drug effects Humans Ligands Models, Molecular Perylene - analogs & derivatives Perylene - pharmacology Piperidines - pharmacology Porphyrins - pharmacology Water - chemistry
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