Insulin-dependent diabetes induced by pancreatic beta cell expression of IL-15 and IL-15Rα

Increased serum levels of IL-15 are reported in type 1 diabetes (T1D). Here we report elevated serum soluble IL-15Rα levels in human T1D. To investigate the role of IL-15/IL-15Rα in the pathogenesis of T1D, we generated double transgenic mice with pancreatic β-cell expression of IL-15 and IL-15Rα. T...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-08, Vol.110 (33), p.13534-13539
Hauptverfasser:	Chen, Jing, Feigenbaum, Lionel, Awasthi, Parirokh, Butcher, Donna O., Anver, Miriam R., Golubeva, Yelena G., Bamford, Richard, Zhang, Xiaojie, St. Claire, Mark B., Thomas, Craig J., Discepolo, Valentina, Jabri, Bana, Waldmann, Thomas A.
Format:	Artikel
Sprache:	eng
Schlagworte:	animal disease models Animals autoantibodies Beta cells Biological Sciences Blood glucose blood serum Diabetes Diabetes Mellitus, Type 1 - etiology Disease Models, Animal Humans Hyperglycemia insulin-dependent diabetes mellitus Insulin-Secreting Cells - metabolism interleukin-15 Interleukin-15 - antagonists & inhibitors Interleukin-15 - blood Interleukin-15 - metabolism Interleukin-15 Receptor alpha Subunit - blood Interleukin-15 Receptor alpha Subunit - metabolism Islet cells islets of Langerhans Mice Mice, Inbred C57BL Mice, Inbred NOD Mice, Transgenic Natural killer cells non-specific protein-tyrosine kinase pathogenesis Piperidines - pharmacology Pyrimidines - pharmacology Pyrroles - pharmacology signal transduction Signal Transduction - drug effects T lymphocytes Transgenic animals Type 1 diabetes mellitus
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!