Cone photoreceptor neuroprotection conferred by CNTF in a novel in vivo model of battlefield retinal laser injury

To develop a reproducible laboratory model to simulate a battlefield foveal laser injury and to test potential neuroprotective effects of a single injection treatment that might be administered in a military setting. Frequency-doubled 532-nm Nd:YAG laser was used to induce a threshold retinal injury...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2013-08, Vol.54 (8), p.5456-5465
Hauptverfasser:	Aslam, Sher A, Davies, Wayne I L, Singh, Mandeep S, Charbel Issa, Peter, Barnard, Alun R, Scott, Robert A H, MacLaren, Robert E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Cell Survival - drug effects Ciliary Neurotrophic Factor - administration & dosage DNA - genetics Eye Burns - drug therapy Eye Burns - metabolism Eye Burns - pathology Fovea Centralis - injuries Gene Expression Regulation - drug effects Green Fluorescent Proteins - biosynthesis Green Fluorescent Proteins - genetics In Situ Nick-End Labeling Intravitreal Injections Lasers, Solid-State - adverse effects Mice Mice, Transgenic Ophthalmoscopy Real-Time Polymerase Chain Reaction Retinal Cone Photoreceptor Cells - drug effects Retinal Cone Photoreceptor Cells - metabolism Retinal Cone Photoreceptor Cells - radiation effects
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