Large or persistent lymphocyst increases the risk of lymphedema, lymphangitis, and deep vein thrombosis after retroperitoneal lymphadenectomy for gynecologic malignancy
Purpose This retrospective study examined the incidence of lymphocyst formation after retroperitoneal lymphadenectomy in patients with gynecologic malignancy as well as the relation between lymphocyst formation and such complications as lymphedema, lymphangitis, ileus, and deep vein thrombosis (DVT)...
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| Veröffentlicht in: | Archives of gynecology and obstetrics 2013-09, Vol.288 (3), p.587-593 |
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| container_title | Archives of gynecology and obstetrics |
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| creator | Kondo, Eiji Tabata, Tsutomu Shiozaki, Takaya Motohashi, Takashi Tanida, Koji Okugawa, Toshiharu Ikeda, Tomoaki |
| description | Purpose
This retrospective study examined the incidence of lymphocyst formation after retroperitoneal lymphadenectomy in patients with gynecologic malignancy as well as the relation between lymphocyst formation and such complications as lymphedema, lymphangitis, ileus, and deep vein thrombosis (DVT).
Methods
Three hundred twenty-one patients who underwent primary surgery with pelvic (90 patients) or combined pelvic and paraaortic lymphadenectomy (231 patients) for gynecologic malignancy between January 2001 and December 2009 were enrolled. The incidences of lymphocyst identified by computed tomography at 3 weeks and 1 year after surgery were analyzed in relation to the types of surgery and types of complications.
Results
At 3 weeks after surgery, lymphocysts were observed in 282/321 patients (88 %). At 1 year after surgery, lymphocysts persisted in 69 patients (21 %). Lymphedema was observed in 34/321 (11 %) patients, lymphangitis in 36/321 (11 %), ileus in 14/321 (4 %), and DVT in 24/321 (7 %). The incidence of lymphedema was significantly greater in patients with persistent lymphocyst than in those with without (17 vs. 9 %) (
p
= 0.038); the incidences of lymphangitis (20 vs. 9 %) (
p
= 0.007) were also greater in this group. Multivariate analysis showed a large lymphocyst (>50 mm) at 3 weeks after surgery to be an independent risk factor for lymphedema (odds ratio 2.76,
p
= 0.009).
Conclusions
A large lymphocyst at 3 weeks after surgery or persistent lymphocyst increases the risk of lymphedema, lymphangitis, and DVT. |
| doi_str_mv | 10.1007/s00404-013-2769-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1424322436</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2261875370</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-b1112b196c62bbd7092b1013c8944737a2f60a156c71fea3d4262bad807296c93</originalsourceid><addsrcrecordid>eNp1kc-K1TAUxoMoznX0AdxIwI2LqZ6kadIuZfAfXHCj65Cmp52MbVKTXKFv5GOaS68KgouQHPL7vnM4HyHPGbxmAOpNAhAgKmB1xZXsKnhADkzUvALF2ENygO78BqmuyJOU7gEYb1v5mFzxWjRNI9iB_DyaOCENka4Yk0sZfabztqx3wW4pU-dtRJMw0XyHNLr0jYZxB3DAxdzsb-Mnl126ocYPdEBc6Q90vmhiWPpQfKkZM0YaMcdQOrkcPJr5Ih7Qo81h2ehYBpm2UoU5TM7Sxcxu8sbb7Sl5NJo54bPLfU2-vn_35fZjdfz84dPt22NlRd3mqmeM8Z510kre94OCrlRlQbbthFC1MnyUYFgjrWIjmnoQvIBmaEHxIurqa_Jq911j-H7ClPXiksV5Nh7DKWkmeNlwObKgL_9B78Mp-jKd5lyyVjW1gkKxnbIxpBRx1Gt0i4mbZqDPMeo9Rl2m1OcY9Vnz4uJ86hcc_ih-51YAvgOpfPkJ49_W_3f9BeFgq20</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2261875370</pqid></control><display><type>article</type><title>Large or persistent lymphocyst increases the risk of lymphedema, lymphangitis, and deep vein thrombosis after retroperitoneal lymphadenectomy for gynecologic malignancy</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Kondo, Eiji ; Tabata, Tsutomu ; Shiozaki, Takaya ; Motohashi, Takashi ; Tanida, Koji ; Okugawa, Toshiharu ; Ikeda, Tomoaki</creator><creatorcontrib>Kondo, Eiji ; Tabata, Tsutomu ; Shiozaki, Takaya ; Motohashi, Takashi ; Tanida, Koji ; Okugawa, Toshiharu ; Ikeda, Tomoaki</creatorcontrib><description>Purpose
This retrospective study examined the incidence of lymphocyst formation after retroperitoneal lymphadenectomy in patients with gynecologic malignancy as well as the relation between lymphocyst formation and such complications as lymphedema, lymphangitis, ileus, and deep vein thrombosis (DVT).
Methods
Three hundred twenty-one patients who underwent primary surgery with pelvic (90 patients) or combined pelvic and paraaortic lymphadenectomy (231 patients) for gynecologic malignancy between January 2001 and December 2009 were enrolled. The incidences of lymphocyst identified by computed tomography at 3 weeks and 1 year after surgery were analyzed in relation to the types of surgery and types of complications.
Results
At 3 weeks after surgery, lymphocysts were observed in 282/321 patients (88 %). At 1 year after surgery, lymphocysts persisted in 69 patients (21 %). Lymphedema was observed in 34/321 (11 %) patients, lymphangitis in 36/321 (11 %), ileus in 14/321 (4 %), and DVT in 24/321 (7 %). The incidence of lymphedema was significantly greater in patients with persistent lymphocyst than in those with without (17 vs. 9 %) (
p
= 0.038); the incidences of lymphangitis (20 vs. 9 %) (
p
= 0.007) were also greater in this group. Multivariate analysis showed a large lymphocyst (>50 mm) at 3 weeks after surgery to be an independent risk factor for lymphedema (odds ratio 2.76,
p
= 0.009).
Conclusions
A large lymphocyst at 3 weeks after surgery or persistent lymphocyst increases the risk of lymphedema, lymphangitis, and DVT.</description><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-013-2769-0</identifier><identifier>PMID: 23455541</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Carcinoma - surgery ; Endocrinology ; Female ; Genital Neoplasms, Female - surgery ; Gynecologic Oncology ; Gynecology ; Human Genetics ; Humans ; Incidence ; Japan - epidemiology ; Lymph Node Excision - adverse effects ; Lymphatic Diseases - epidemiology ; Lymphatic Diseases - etiology ; Lymphedema ; Medicine ; Medicine & Public Health ; Middle Aged ; Multivariate Analysis ; Obstetrics/Perinatology/Midwifery ; Postoperative Complications - epidemiology ; Postoperative Complications - etiology ; Retroperitoneal Space - surgery ; Retrospective Studies ; Surgery ; Thrombosis ; Venous Thrombosis - epidemiology ; Venous Thrombosis - etiology</subject><ispartof>Archives of gynecology and obstetrics, 2013-09, Vol.288 (3), p.587-593</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><rights>Archives of Gynecology and Obstetrics is a copyright of Springer, (2013). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-b1112b196c62bbd7092b1013c8944737a2f60a156c71fea3d4262bad807296c93</citedby><cites>FETCH-LOGICAL-c438t-b1112b196c62bbd7092b1013c8944737a2f60a156c71fea3d4262bad807296c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00404-013-2769-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00404-013-2769-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23455541$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kondo, Eiji</creatorcontrib><creatorcontrib>Tabata, Tsutomu</creatorcontrib><creatorcontrib>Shiozaki, Takaya</creatorcontrib><creatorcontrib>Motohashi, Takashi</creatorcontrib><creatorcontrib>Tanida, Koji</creatorcontrib><creatorcontrib>Okugawa, Toshiharu</creatorcontrib><creatorcontrib>Ikeda, Tomoaki</creatorcontrib><title>Large or persistent lymphocyst increases the risk of lymphedema, lymphangitis, and deep vein thrombosis after retroperitoneal lymphadenectomy for gynecologic malignancy</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description>Purpose
This retrospective study examined the incidence of lymphocyst formation after retroperitoneal lymphadenectomy in patients with gynecologic malignancy as well as the relation between lymphocyst formation and such complications as lymphedema, lymphangitis, ileus, and deep vein thrombosis (DVT).
Methods
Three hundred twenty-one patients who underwent primary surgery with pelvic (90 patients) or combined pelvic and paraaortic lymphadenectomy (231 patients) for gynecologic malignancy between January 2001 and December 2009 were enrolled. The incidences of lymphocyst identified by computed tomography at 3 weeks and 1 year after surgery were analyzed in relation to the types of surgery and types of complications.
Results
At 3 weeks after surgery, lymphocysts were observed in 282/321 patients (88 %). At 1 year after surgery, lymphocysts persisted in 69 patients (21 %). Lymphedema was observed in 34/321 (11 %) patients, lymphangitis in 36/321 (11 %), ileus in 14/321 (4 %), and DVT in 24/321 (7 %). The incidence of lymphedema was significantly greater in patients with persistent lymphocyst than in those with without (17 vs. 9 %) (
p
= 0.038); the incidences of lymphangitis (20 vs. 9 %) (
p
= 0.007) were also greater in this group. Multivariate analysis showed a large lymphocyst (>50 mm) at 3 weeks after surgery to be an independent risk factor for lymphedema (odds ratio 2.76,
p
= 0.009).
Conclusions
A large lymphocyst at 3 weeks after surgery or persistent lymphocyst increases the risk of lymphedema, lymphangitis, and DVT.</description><subject>Adult</subject><subject>Carcinoma - surgery</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Genital Neoplasms, Female - surgery</subject><subject>Gynecologic Oncology</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Incidence</subject><subject>Japan - epidemiology</subject><subject>Lymph Node Excision - adverse effects</subject><subject>Lymphatic Diseases - epidemiology</subject><subject>Lymphatic Diseases - etiology</subject><subject>Lymphedema</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Postoperative Complications - epidemiology</subject><subject>Postoperative Complications - etiology</subject><subject>Retroperitoneal Space - surgery</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Thrombosis</subject><subject>Venous Thrombosis - epidemiology</subject><subject>Venous Thrombosis - etiology</subject><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kc-K1TAUxoMoznX0AdxIwI2LqZ6kadIuZfAfXHCj65Cmp52MbVKTXKFv5GOaS68KgouQHPL7vnM4HyHPGbxmAOpNAhAgKmB1xZXsKnhADkzUvALF2ENygO78BqmuyJOU7gEYb1v5mFzxWjRNI9iB_DyaOCENka4Yk0sZfabztqx3wW4pU-dtRJMw0XyHNLr0jYZxB3DAxdzsb-Mnl126ocYPdEBc6Q90vmhiWPpQfKkZM0YaMcdQOrkcPJr5Ih7Qo81h2ehYBpm2UoU5TM7Sxcxu8sbb7Sl5NJo54bPLfU2-vn_35fZjdfz84dPt22NlRd3mqmeM8Z510kre94OCrlRlQbbthFC1MnyUYFgjrWIjmnoQvIBmaEHxIurqa_Jq911j-H7ClPXiksV5Nh7DKWkmeNlwObKgL_9B78Mp-jKd5lyyVjW1gkKxnbIxpBRx1Gt0i4mbZqDPMeo9Rl2m1OcY9Vnz4uJ86hcc_ih-51YAvgOpfPkJ49_W_3f9BeFgq20</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Kondo, Eiji</creator><creator>Tabata, Tsutomu</creator><creator>Shiozaki, Takaya</creator><creator>Motohashi, Takashi</creator><creator>Tanida, Koji</creator><creator>Okugawa, Toshiharu</creator><creator>Ikeda, Tomoaki</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20130901</creationdate><title>Large or persistent lymphocyst increases the risk of lymphedema, lymphangitis, and deep vein thrombosis after retroperitoneal lymphadenectomy for gynecologic malignancy</title><author>Kondo, Eiji ; Tabata, Tsutomu ; Shiozaki, Takaya ; Motohashi, Takashi ; Tanida, Koji ; Okugawa, Toshiharu ; Ikeda, Tomoaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-b1112b196c62bbd7092b1013c8944737a2f60a156c71fea3d4262bad807296c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Carcinoma - surgery</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Genital Neoplasms, Female - surgery</topic><topic>Gynecologic Oncology</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Incidence</topic><topic>Japan - epidemiology</topic><topic>Lymph Node Excision - adverse effects</topic><topic>Lymphatic Diseases - epidemiology</topic><topic>Lymphatic Diseases - etiology</topic><topic>Lymphedema</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Postoperative Complications - epidemiology</topic><topic>Postoperative Complications - etiology</topic><topic>Retroperitoneal Space - surgery</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Thrombosis</topic><topic>Venous Thrombosis - epidemiology</topic><topic>Venous Thrombosis - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kondo, Eiji</creatorcontrib><creatorcontrib>Tabata, Tsutomu</creatorcontrib><creatorcontrib>Shiozaki, Takaya</creatorcontrib><creatorcontrib>Motohashi, Takashi</creatorcontrib><creatorcontrib>Tanida, Koji</creatorcontrib><creatorcontrib>Okugawa, Toshiharu</creatorcontrib><creatorcontrib>Ikeda, Tomoaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kondo, Eiji</au><au>Tabata, Tsutomu</au><au>Shiozaki, Takaya</au><au>Motohashi, Takashi</au><au>Tanida, Koji</au><au>Okugawa, Toshiharu</au><au>Ikeda, Tomoaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Large or persistent lymphocyst increases the risk of lymphedema, lymphangitis, and deep vein thrombosis after retroperitoneal lymphadenectomy for gynecologic malignancy</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><stitle>Arch Gynecol Obstet</stitle><addtitle>Arch Gynecol Obstet</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>288</volume><issue>3</issue><spage>587</spage><epage>593</epage><pages>587-593</pages><issn>0932-0067</issn><eissn>1432-0711</eissn><abstract>Purpose
This retrospective study examined the incidence of lymphocyst formation after retroperitoneal lymphadenectomy in patients with gynecologic malignancy as well as the relation between lymphocyst formation and such complications as lymphedema, lymphangitis, ileus, and deep vein thrombosis (DVT).
Methods
Three hundred twenty-one patients who underwent primary surgery with pelvic (90 patients) or combined pelvic and paraaortic lymphadenectomy (231 patients) for gynecologic malignancy between January 2001 and December 2009 were enrolled. The incidences of lymphocyst identified by computed tomography at 3 weeks and 1 year after surgery were analyzed in relation to the types of surgery and types of complications.
Results
At 3 weeks after surgery, lymphocysts were observed in 282/321 patients (88 %). At 1 year after surgery, lymphocysts persisted in 69 patients (21 %). Lymphedema was observed in 34/321 (11 %) patients, lymphangitis in 36/321 (11 %), ileus in 14/321 (4 %), and DVT in 24/321 (7 %). The incidence of lymphedema was significantly greater in patients with persistent lymphocyst than in those with without (17 vs. 9 %) (
p
= 0.038); the incidences of lymphangitis (20 vs. 9 %) (
p
= 0.007) were also greater in this group. Multivariate analysis showed a large lymphocyst (>50 mm) at 3 weeks after surgery to be an independent risk factor for lymphedema (odds ratio 2.76,
p
= 0.009).
Conclusions
A large lymphocyst at 3 weeks after surgery or persistent lymphocyst increases the risk of lymphedema, lymphangitis, and DVT.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>23455541</pmid><doi>10.1007/s00404-013-2769-0</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0932-0067 |
| ispartof | Archives of gynecology and obstetrics, 2013-09, Vol.288 (3), p.587-593 |
| issn | 0932-0067 1432-0711 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1424322436 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Carcinoma - surgery Endocrinology Female Genital Neoplasms, Female - surgery Gynecologic Oncology Gynecology Human Genetics Humans Incidence Japan - epidemiology Lymph Node Excision - adverse effects Lymphatic Diseases - epidemiology Lymphatic Diseases - etiology Lymphedema Medicine Medicine & Public Health Middle Aged Multivariate Analysis Obstetrics/Perinatology/Midwifery Postoperative Complications - epidemiology Postoperative Complications - etiology Retroperitoneal Space - surgery Retrospective Studies Surgery Thrombosis Venous Thrombosis - epidemiology Venous Thrombosis - etiology |
| title | Large or persistent lymphocyst increases the risk of lymphedema, lymphangitis, and deep vein thrombosis after retroperitoneal lymphadenectomy for gynecologic malignancy |
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