First studies on the bioconcentration and immunotoxicity of tetrachlorodiarylmethanes in the rat
An immunotoxicity test was conducted by administration of tetanus toxoid to rats fed either with a standard diet or with diets containing tetrachlorodiarylmethanes (TCDAMs), PCBs and hydrocortisone (HY); the serum level of tetanus antitoxin was evaluated using the passive HA technique. The results r...
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| Veröffentlicht in: | Bulletin of environmental contamination and toxicology 1988-10, Vol.41 (4), p.523-530 |
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| container_title | Bulletin of environmental contamination and toxicology |
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| creator | LEONI, V MASTROENI, I VESCIA, N FABIANI, L GIULIANI, A. R |
| description | An immunotoxicity test was conducted by administration of tetanus toxoid to rats fed either with a standard diet or with diets containing tetrachlorodiarylmethanes (TCDAMs), PCBs and hydrocortisone (HY); the serum level of tetanus antitoxin was evaluated using the passive HA technique. The results relative to PCBs do not indicate a reduction of humoral response in the rat for treatment of 200 ppm for ten weeks. For rats treated with TCDAM, the kinetics of Ab response indicates for the primary response a statistically significant reduction compared to the controls in the males treated with 200 ppm and in the males and females treated with 1000 ppm. The amount of the deposits in the fatty tissues is correlated with the doses in the diets. |
| doi_str_mv | 10.1007/BF02020996 |
| format | Article |
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Toxic occupational diseases</subject><subject>Chromatography, Gas</subject><subject>Diet</subject><subject>Female</subject><subject>Hydrocarbons, Chlorinated - metabolism</subject><subject>Hydrocarbons, Chlorinated - toxicity</subject><subject>Hydrocortisone - toxicity</subject><subject>Immunity - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Polychlorinated Biphenyls - toxicity</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Tetanus Toxin - immunology</subject><subject>Tetanus Toxin - toxicity</subject><subject>Toxicology</subject><subject>Various organic compounds</subject><issn>0007-4861</issn><issn>1432-0800</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1LAzEQxYMotVYv3oU9iAdhNV9Ns0ctVoWCFz2vSXZCI7ubmmTB_vdGulTmMDDvN4_HQ-iS4DuC8eL-cYVpnqoSR2hKOKMllhgfoynOasmlIKfoLMYvjMlcUjpBE0a4qCo-RZ8rF2IqYhoaB7HwfZE2UGjnje8N9Cmo5PJR9U3hum7offI_zri0K7wtEmTdbFoffONU2LUdpI3qs4_b--Tvc3RiVRvhYtwz9LF6el--lOu359flw7o0jNNUMjaXmHCjAcBwLbUFgiXX1iykVaLhIGQFinPeaKO54nMrmNUNrQRUQgg2Qzd7323w3wPEVHcuGmjbnMcPsSacUkLZIoO3e9AEH2MAW2-D63L6muD6r876v84MX42ug-6gOaBjf1m_HnUVjWptUL1x8YAtaOYEZr-_LX6K</recordid><startdate>19881001</startdate><enddate>19881001</enddate><creator>LEONI, V</creator><creator>MASTROENI, I</creator><creator>VESCIA, N</creator><creator>FABIANI, L</creator><creator>GIULIANI, A. 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R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>First studies on the bioconcentration and immunotoxicity of tetrachlorodiarylmethanes in the rat</atitle><jtitle>Bulletin of environmental contamination and toxicology</jtitle><addtitle>Bull Environ Contam Toxicol</addtitle><date>1988-10-01</date><risdate>1988</risdate><volume>41</volume><issue>4</issue><spage>523</spage><epage>530</epage><pages>523-530</pages><issn>0007-4861</issn><eissn>1432-0800</eissn><coden>BECTA6</coden><abstract>An immunotoxicity test was conducted by administration of tetanus toxoid to rats fed either with a standard diet or with diets containing tetrachlorodiarylmethanes (TCDAMs), PCBs and hydrocortisone (HY); the serum level of tetanus antitoxin was evaluated using the passive HA technique. The results relative to PCBs do not indicate a reduction of humoral response in the rat for treatment of 200 ppm for ten weeks. For rats treated with TCDAM, the kinetics of Ab response indicates for the primary response a statistically significant reduction compared to the controls in the males treated with 200 ppm and in the males and females treated with 1000 ppm. The amount of the deposits in the fatty tissues is correlated with the doses in the diets.</abstract><cop>New York, NY</cop><pub>Springer-Verlag</pub><pmid>3146994</pmid><doi>10.1007/BF02020996</doi><tpages>8</tpages></addata></record> |
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| ispartof | Bulletin of environmental contamination and toxicology, 1988-10, Vol.41 (4), p.523-530 |
| issn | 0007-4861 1432-0800 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_14221237 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adipose Tissue - drug effects Adipose Tissue - metabolism Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Chromatography, Gas Diet Female Hydrocarbons, Chlorinated - metabolism Hydrocarbons, Chlorinated - toxicity Hydrocortisone - toxicity Immunity - drug effects Male Medical sciences Polychlorinated Biphenyls - toxicity Rats Rats, Inbred Strains Tetanus Toxin - immunology Tetanus Toxin - toxicity Toxicology Various organic compounds |
| title | First studies on the bioconcentration and immunotoxicity of tetrachlorodiarylmethanes in the rat |
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