Amnesia attenuation specificity: Propranolol reverses norepinephrine but not cycloheximide-induced amnesia

Post-trial injections of norepinephrine (NE) or cycloheximide (CHX) into the amygdala produces a long-term retention deficit (amnesia) for a 1-trial footshock experience in rats. Concomitant post-trial injections of the adrenergic antagonist, propranolol, prevents NE-, but not CHX-induced amnesia. T...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1983-01, Vol.19 (5), p.733-736
Hauptverfasser:	Ellis, Maureen E., Berman, Robert F., Kesner, Raymond P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amnesia Amnesia - chemically induced Amnesia, Retrograde - chemically induced Amnesia, Retrograde - physiopathology Amygdala Animals Aversive information processing Avoidance Learning - drug effects Biological and medical sciences Cycloheximide Cycloheximide - pharmacology Differential attenuation Drug Interactions General aspects Humans Male Medical sciences Memory mechanisms Neuropharmacology Norepinephrine Norepinephrine - pharmacology Norepinephrine - physiology Pharmacology. Drug treatments Propranolol Propranolol - pharmacology Rats Reaction Time - drug effects
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Zusammenfassung:	Post-trial injections of norepinephrine (NE) or cycloheximide (CHX) into the amygdala produces a long-term retention deficit (amnesia) for a 1-trial footshock experience in rats. Concomitant post-trial injections of the adrenergic antagonist, propranolol, prevents NE-, but not CHX-induced amnesia. These results indicate separate mechanisms of action for amnesia produced by intracranial CHX and NE injections.
ISSN:	0091-3057 1873-5177
DOI:	10.1016/0091-3057(83)90071-0