Grating-based darkfield imaging of human breast tissue
Mastectomy specimens were investigated using a Talbot-Lau X-ray imaging set-up. Significant structures in the darkfield were observed, which revealed considerably higher contrast than those observed in digital mammography. Comparison with the histomorphometric image proofs that the darkfield signal...
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| Veröffentlicht in: | Zeitschrift für medizinische Physik 2013-09, Vol.23 (3), p.228-235 |
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| creator | Anton, Gisela Bayer, Florian Beckmann, Matthias W. Durst, Jürgen Fasching, Peter A. Haas, Wilhelm Hartmann, Arndt Michel, Thilo Pelzer, Georg Radicke, Marcus Rauh, Claudia Rieger, Jens Ritter, André Schulz-Wendtland, Rüdiger Uder, Michael Wachter, David L. Weber, Thomas Wenkel, Evelyn Wucherer, Lukas |
| description | Mastectomy specimens were investigated using a Talbot-Lau X-ray imaging set-up. Significant structures in the darkfield were observed, which revealed considerably higher contrast than those observed in digital mammography. Comparison with the histomorphometric image proofs that the darkfield signal correlates with a tumor region containing small calcification grains of 3 to 30μm size.
Es wurden Mastektomieproben mit Hilfe eines Talbot-Lau-Röntgenaufbaus untersucht, wobei Strukturen im Dunkelfeldbild auftraten, die einen deutlich höheren Kontrast aufwiesen, als er in einem konventionellen, digitalen Mammographiebild beobachtet werden konnte. Durch den Vergleich mit histomorphometrischen Bildern konnte nachgewiesen werden, dass das beobachtete Dunkelfeldsignal mit einer Tumorregion korreliert ist, die Kalzifikationen der Größe 3 bis 30μm enthält. |
| doi_str_mv | 10.1016/j.zemedi.2013.01.001 |
| format | Article |
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Es wurden Mastektomieproben mit Hilfe eines Talbot-Lau-Röntgenaufbaus untersucht, wobei Strukturen im Dunkelfeldbild auftraten, die einen deutlich höheren Kontrast aufwiesen, als er in einem konventionellen, digitalen Mammographiebild beobachtet werden konnte. Durch den Vergleich mit histomorphometrischen Bildern konnte nachgewiesen werden, dass das beobachtete Dunkelfeldsignal mit einer Tumorregion korreliert ist, die Kalzifikationen der Größe 3 bis 30μm enthält.</description><identifier>ISSN: 0939-3889</identifier><identifier>EISSN: 1876-4436</identifier><identifier>DOI: 10.1016/j.zemedi.2013.01.001</identifier><identifier>PMID: 23380071</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>breast cancer ; Breast Neoplasms - diagnostic imaging ; Breast Neoplasms - etiology ; Brustkrebs ; Cadaver ; Calcinosis - complications ; Calcinosis - diagnostic imaging ; darkfield imaging ; Dunkelfeldbildgebung ; Equipment Design ; Equipment Failure Analysis ; Feasibility Studies ; Humans ; Interferometry - instrumentation ; Interferometry - methods ; Mammographie ; mammography ; Mammography - instrumentation ; Mammography - methods ; microcalcification ; Mikrokalzifikation ; Refractometry - instrumentation ; Refractometry - methods ; Reproducibility of Results ; Röntgenbildgebung ; Sensitivity and Specificity ; Talbot-Lau ; Tomography, X-Ray Computed - instrumentation ; Tomography, X-Ray Computed - methods ; X-Ray Diffraction - instrumentation ; X-Ray Diffraction - methods ; X-ray imaging</subject><ispartof>Zeitschrift für medizinische Physik, 2013-09, Vol.23 (3), p.228-235</ispartof><rights>2013</rights><rights>Copyright © 2013. Published by Elsevier GmbH.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-7d7aa915277b6e5f692191a97157e459dee1bf110427de2f622b05c37827f7643</citedby><cites>FETCH-LOGICAL-c408t-7d7aa915277b6e5f692191a97157e459dee1bf110427de2f622b05c37827f7643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0939388913000032$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23380071$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anton, Gisela</creatorcontrib><creatorcontrib>Bayer, Florian</creatorcontrib><creatorcontrib>Beckmann, Matthias W.</creatorcontrib><creatorcontrib>Durst, Jürgen</creatorcontrib><creatorcontrib>Fasching, Peter A.</creatorcontrib><creatorcontrib>Haas, Wilhelm</creatorcontrib><creatorcontrib>Hartmann, Arndt</creatorcontrib><creatorcontrib>Michel, Thilo</creatorcontrib><creatorcontrib>Pelzer, Georg</creatorcontrib><creatorcontrib>Radicke, Marcus</creatorcontrib><creatorcontrib>Rauh, Claudia</creatorcontrib><creatorcontrib>Rieger, Jens</creatorcontrib><creatorcontrib>Ritter, André</creatorcontrib><creatorcontrib>Schulz-Wendtland, Rüdiger</creatorcontrib><creatorcontrib>Uder, Michael</creatorcontrib><creatorcontrib>Wachter, David L.</creatorcontrib><creatorcontrib>Weber, Thomas</creatorcontrib><creatorcontrib>Wenkel, Evelyn</creatorcontrib><creatorcontrib>Wucherer, Lukas</creatorcontrib><title>Grating-based darkfield imaging of human breast tissue</title><title>Zeitschrift für medizinische Physik</title><addtitle>Z Med Phys</addtitle><description>Mastectomy specimens were investigated using a Talbot-Lau X-ray imaging set-up. Significant structures in the darkfield were observed, which revealed considerably higher contrast than those observed in digital mammography. Comparison with the histomorphometric image proofs that the darkfield signal correlates with a tumor region containing small calcification grains of 3 to 30μm size.
Es wurden Mastektomieproben mit Hilfe eines Talbot-Lau-Röntgenaufbaus untersucht, wobei Strukturen im Dunkelfeldbild auftraten, die einen deutlich höheren Kontrast aufwiesen, als er in einem konventionellen, digitalen Mammographiebild beobachtet werden konnte. Durch den Vergleich mit histomorphometrischen Bildern konnte nachgewiesen werden, dass das beobachtete Dunkelfeldsignal mit einer Tumorregion korreliert ist, die Kalzifikationen der Größe 3 bis 30μm enthält.</description><subject>breast cancer</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Breast Neoplasms - etiology</subject><subject>Brustkrebs</subject><subject>Cadaver</subject><subject>Calcinosis - complications</subject><subject>Calcinosis - diagnostic imaging</subject><subject>darkfield imaging</subject><subject>Dunkelfeldbildgebung</subject><subject>Equipment Design</subject><subject>Equipment Failure Analysis</subject><subject>Feasibility Studies</subject><subject>Humans</subject><subject>Interferometry - instrumentation</subject><subject>Interferometry - methods</subject><subject>Mammographie</subject><subject>mammography</subject><subject>Mammography - instrumentation</subject><subject>Mammography - methods</subject><subject>microcalcification</subject><subject>Mikrokalzifikation</subject><subject>Refractometry - instrumentation</subject><subject>Refractometry - methods</subject><subject>Reproducibility of Results</subject><subject>Röntgenbildgebung</subject><subject>Sensitivity and Specificity</subject><subject>Talbot-Lau</subject><subject>Tomography, X-Ray Computed - instrumentation</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>X-Ray Diffraction - instrumentation</subject><subject>X-Ray Diffraction - methods</subject><subject>X-ray imaging</subject><issn>0939-3889</issn><issn>1876-4436</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtPwzAQhC0EoqXwDxDKkUvCrpPYyQUJVbykSlzgbDnJurjkUewECX49KSkcOa20-82sZhg7R4gQUFxtoi9qqLIRB4wjwAgAD9gcMynCJInFIZtDHudhnGX5jJ14vwFIJQp-zGY8jjMAiXMm7p3ubbsOC-2pCirt3oylugpso9fjPuhM8Do0ug0KR9r3QW-9H-iUHRldezrbzwV7ubt9Xj6Eq6f7x-XNKiwTyPpQVlLrHFMuZSEoNSLnmKPOJaaSkjSviLAwiJBwWRE3gvMC0jKWGZdGiiResMvJd-u694F8rxrrS6pr3VI3eIXJmF7CroIFSya0dJ33jozaujGE-1QIateY2qipMbXDFaCCH9nF_sNQjMc_0W9FI3A9ATTm_LDklC8tteVo5KjsVdXZ_z98A79ofFI</recordid><startdate>201309</startdate><enddate>201309</enddate><creator>Anton, Gisela</creator><creator>Bayer, Florian</creator><creator>Beckmann, Matthias W.</creator><creator>Durst, Jürgen</creator><creator>Fasching, Peter A.</creator><creator>Haas, Wilhelm</creator><creator>Hartmann, Arndt</creator><creator>Michel, Thilo</creator><creator>Pelzer, Georg</creator><creator>Radicke, Marcus</creator><creator>Rauh, Claudia</creator><creator>Rieger, Jens</creator><creator>Ritter, André</creator><creator>Schulz-Wendtland, Rüdiger</creator><creator>Uder, Michael</creator><creator>Wachter, David L.</creator><creator>Weber, Thomas</creator><creator>Wenkel, Evelyn</creator><creator>Wucherer, Lukas</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201309</creationdate><title>Grating-based darkfield imaging of human breast tissue</title><author>Anton, Gisela ; Bayer, Florian ; Beckmann, Matthias W. ; Durst, Jürgen ; Fasching, Peter A. ; Haas, Wilhelm ; Hartmann, Arndt ; Michel, Thilo ; Pelzer, Georg ; Radicke, Marcus ; Rauh, Claudia ; Rieger, Jens ; Ritter, André ; Schulz-Wendtland, Rüdiger ; Uder, Michael ; Wachter, David L. ; Weber, Thomas ; Wenkel, Evelyn ; Wucherer, Lukas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-7d7aa915277b6e5f692191a97157e459dee1bf110427de2f622b05c37827f7643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>breast cancer</topic><topic>Breast Neoplasms - diagnostic imaging</topic><topic>Breast Neoplasms - etiology</topic><topic>Brustkrebs</topic><topic>Cadaver</topic><topic>Calcinosis - complications</topic><topic>Calcinosis - diagnostic imaging</topic><topic>darkfield imaging</topic><topic>Dunkelfeldbildgebung</topic><topic>Equipment Design</topic><topic>Equipment Failure Analysis</topic><topic>Feasibility Studies</topic><topic>Humans</topic><topic>Interferometry - instrumentation</topic><topic>Interferometry - methods</topic><topic>Mammographie</topic><topic>mammography</topic><topic>Mammography - instrumentation</topic><topic>Mammography - methods</topic><topic>microcalcification</topic><topic>Mikrokalzifikation</topic><topic>Refractometry - instrumentation</topic><topic>Refractometry - methods</topic><topic>Reproducibility of Results</topic><topic>Röntgenbildgebung</topic><topic>Sensitivity and Specificity</topic><topic>Talbot-Lau</topic><topic>Tomography, X-Ray Computed - instrumentation</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>X-Ray Diffraction - instrumentation</topic><topic>X-Ray Diffraction - methods</topic><topic>X-ray imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anton, Gisela</creatorcontrib><creatorcontrib>Bayer, Florian</creatorcontrib><creatorcontrib>Beckmann, Matthias W.</creatorcontrib><creatorcontrib>Durst, Jürgen</creatorcontrib><creatorcontrib>Fasching, Peter A.</creatorcontrib><creatorcontrib>Haas, Wilhelm</creatorcontrib><creatorcontrib>Hartmann, Arndt</creatorcontrib><creatorcontrib>Michel, Thilo</creatorcontrib><creatorcontrib>Pelzer, Georg</creatorcontrib><creatorcontrib>Radicke, Marcus</creatorcontrib><creatorcontrib>Rauh, Claudia</creatorcontrib><creatorcontrib>Rieger, Jens</creatorcontrib><creatorcontrib>Ritter, André</creatorcontrib><creatorcontrib>Schulz-Wendtland, Rüdiger</creatorcontrib><creatorcontrib>Uder, Michael</creatorcontrib><creatorcontrib>Wachter, David L.</creatorcontrib><creatorcontrib>Weber, Thomas</creatorcontrib><creatorcontrib>Wenkel, Evelyn</creatorcontrib><creatorcontrib>Wucherer, Lukas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Zeitschrift für medizinische Physik</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anton, Gisela</au><au>Bayer, Florian</au><au>Beckmann, Matthias W.</au><au>Durst, Jürgen</au><au>Fasching, Peter A.</au><au>Haas, Wilhelm</au><au>Hartmann, Arndt</au><au>Michel, Thilo</au><au>Pelzer, Georg</au><au>Radicke, Marcus</au><au>Rauh, Claudia</au><au>Rieger, Jens</au><au>Ritter, André</au><au>Schulz-Wendtland, Rüdiger</au><au>Uder, Michael</au><au>Wachter, David L.</au><au>Weber, Thomas</au><au>Wenkel, Evelyn</au><au>Wucherer, Lukas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Grating-based darkfield imaging of human breast tissue</atitle><jtitle>Zeitschrift für medizinische Physik</jtitle><addtitle>Z Med Phys</addtitle><date>2013-09</date><risdate>2013</risdate><volume>23</volume><issue>3</issue><spage>228</spage><epage>235</epage><pages>228-235</pages><issn>0939-3889</issn><eissn>1876-4436</eissn><abstract>Mastectomy specimens were investigated using a Talbot-Lau X-ray imaging set-up. Significant structures in the darkfield were observed, which revealed considerably higher contrast than those observed in digital mammography. Comparison with the histomorphometric image proofs that the darkfield signal correlates with a tumor region containing small calcification grains of 3 to 30μm size.
Es wurden Mastektomieproben mit Hilfe eines Talbot-Lau-Röntgenaufbaus untersucht, wobei Strukturen im Dunkelfeldbild auftraten, die einen deutlich höheren Kontrast aufwiesen, als er in einem konventionellen, digitalen Mammographiebild beobachtet werden konnte. Durch den Vergleich mit histomorphometrischen Bildern konnte nachgewiesen werden, dass das beobachtete Dunkelfeldsignal mit einer Tumorregion korreliert ist, die Kalzifikationen der Größe 3 bis 30μm enthält.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>23380071</pmid><doi>10.1016/j.zemedi.2013.01.001</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | breast cancer Breast Neoplasms - diagnostic imaging Breast Neoplasms - etiology Brustkrebs Cadaver Calcinosis - complications Calcinosis - diagnostic imaging darkfield imaging Dunkelfeldbildgebung Equipment Design Equipment Failure Analysis Feasibility Studies Humans Interferometry - instrumentation Interferometry - methods Mammographie mammography Mammography - instrumentation Mammography - methods microcalcification Mikrokalzifikation Refractometry - instrumentation Refractometry - methods Reproducibility of Results Röntgenbildgebung Sensitivity and Specificity Talbot-Lau Tomography, X-Ray Computed - instrumentation Tomography, X-Ray Computed - methods X-Ray Diffraction - instrumentation X-Ray Diffraction - methods X-ray imaging |
| title | Grating-based darkfield imaging of human breast tissue |
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