Lysophosphatidic acid increases the production of pivotal mediators of decidualization and vascularization in the rat uterus

Abstract Introduction The decidual reaction and the formation of new vessels in the uterus are two crucial processes during embryo implantation. Previously, we observed that lysophosphatidic acid (LPA) increases cyclooxygenase-2 derived – prostaglandin E2 production during implantation in the rat ut...

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Veröffentlicht in:	Placenta (Eastbourne) 2013-09, Vol.34 (9), p.751-756
Hauptverfasser:	Beltrame, J.S, Sordelli, M.S, Cella, M, Perez Martinez, S, Franchi, A.M, Ribeiro, M.L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biomarkers - metabolism Cyclooxygenase 2 - chemistry Cyclooxygenase 2 - metabolism Cyclooxygenase 2 Inhibitors - pharmacology Cyclooxygenase-2 Decidua - blood supply Decidua - cytology Decidua - drug effects Decidua - metabolism Decidualization Dinoprostone - metabolism Embryo Implantation - drug effects Embryology: invertebrates and vertebrates. Teratology Enzyme Inhibitors - pharmacology Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental - drug effects Implantation Inducible nitric oxide synthase Insulin-Like Growth Factor Binding Protein 1 - genetics Insulin-Like Growth Factor Binding Protein 1 - metabolism Interleukin-10 - genetics Interleukin-10 - metabolism Internal Medicine Lysophosphatidic acid Lysophospholipids - antagonists & inhibitors Lysophospholipids - metabolism Nitric Oxide Synthase Type II - antagonists & inhibitors Nitric Oxide Synthase Type II - metabolism Obstetrics and Gynecology Placentation Pregnancy Protein Isoforms - antagonists & inhibitors Protein Isoforms - metabolism Rats Rats, Wistar Receptors, Lysophosphatidic Acid - antagonists & inhibitors Receptors, Lysophosphatidic Acid - metabolism Signal Transduction - drug effects Uterus - blood supply Uterus - cytology Uterus - drug effects Uterus - metabolism Vascularization
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