Elevated levels of multiple biomarkers of Alzheimer's disease in the aqueous humor of eyes with open-angle glaucoma
To investigate levels of biomarkers of Alzheimer's disease in the aqueous humor in patients with open-angle glaucoma (OAG). Aqueous humor samples were collected from 38 patients with cataracts, 20 patients with POAG, and 32 patients with exfoliation glaucoma. Aqueous levels of apolipoprotein (A...
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| Veröffentlicht in: | Investigative ophthalmology & visual science 2013-08, Vol.54 (8), p.5353-5358 |
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| creator | Inoue, Toshihiro Kawaji, Takahiro Tanihara, Hidenobu |
| description | To investigate levels of biomarkers of Alzheimer's disease in the aqueous humor in patients with open-angle glaucoma (OAG).
Aqueous humor samples were collected from 38 patients with cataracts, 20 patients with POAG, and 32 patients with exfoliation glaucoma. Aqueous levels of apolipoprotein (Apo) AI, ApoCIII, ApoE, transthyretin (TTR), complement factor H, complement C3, and α2-macroglobulin (α2M) were determined by multiplex bead immunoassay. Clinical data were obtained from medical charts.
Age and sex did not differ significantly among groups. POAG patients had significantly higher aqueous levels of Apo AI, ApoCIII, ApoE, TTR, and α2M compared with cataract patients (P < 0.001, P = 0.036, P < 0.001, P < 0.001, and P < 0.001, respectively). Corresponding values for exfoliation glaucoma patients were also significantly higher compared with those for cataract patients (P = 0.003, P = 0.009, P < 0.001, P < 0.001, and P < 0.001), and those levels correlated positively with each other in eyes with OAG (P < 0.001 for all combinations). Complement factor H and complement C3 levels did not differ among groups. Mean deviation values for the Humphrey visual field test correlated positively with levels of Apo AI, ApoE, TTR, and complement factor H in OAG patients (P = 0.026, 0.012, 0.008, and 0.027, respectively), but age and IOP values were not correlated with protein levels.
OAG patients had elevated levels of multiple biomarkers of Alzheimer's disease in the aqueous humor. |
| doi_str_mv | 10.1167/iovs.13-12245 |
| format | Article |
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Aqueous humor samples were collected from 38 patients with cataracts, 20 patients with POAG, and 32 patients with exfoliation glaucoma. Aqueous levels of apolipoprotein (Apo) AI, ApoCIII, ApoE, transthyretin (TTR), complement factor H, complement C3, and α2-macroglobulin (α2M) were determined by multiplex bead immunoassay. Clinical data were obtained from medical charts.
Age and sex did not differ significantly among groups. POAG patients had significantly higher aqueous levels of Apo AI, ApoCIII, ApoE, TTR, and α2M compared with cataract patients (P < 0.001, P = 0.036, P < 0.001, P < 0.001, and P < 0.001, respectively). Corresponding values for exfoliation glaucoma patients were also significantly higher compared with those for cataract patients (P = 0.003, P = 0.009, P < 0.001, P < 0.001, and P < 0.001), and those levels correlated positively with each other in eyes with OAG (P < 0.001 for all combinations). Complement factor H and complement C3 levels did not differ among groups. Mean deviation values for the Humphrey visual field test correlated positively with levels of Apo AI, ApoE, TTR, and complement factor H in OAG patients (P = 0.026, 0.012, 0.008, and 0.027, respectively), but age and IOP values were not correlated with protein levels.
OAG patients had elevated levels of multiple biomarkers of Alzheimer's disease in the aqueous humor.]]></description><identifier>ISSN: 1552-5783</identifier><identifier>EISSN: 1552-5783</identifier><identifier>DOI: 10.1167/iovs.13-12245</identifier><identifier>PMID: 23860758</identifier><language>eng</language><publisher>United States</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - complications ; Alzheimer Disease - metabolism ; Aqueous Humor - metabolism ; Biomarkers - metabolism ; Cross-Sectional Studies ; Disease Progression ; Enzyme-Linked Immunosorbent Assay ; Eye Proteins - metabolism ; Female ; Glaucoma, Open-Angle - complications ; Glaucoma, Open-Angle - metabolism ; Humans ; Male ; Middle Aged ; Severity of Illness Index</subject><ispartof>Investigative ophthalmology & visual science, 2013-08, Vol.54 (8), p.5353-5358</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-e8061a8fcacc3c8add7fdf2b6fab11cbeed1a02732141f65cfeec3ab13acb2283</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23860758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inoue, Toshihiro</creatorcontrib><creatorcontrib>Kawaji, Takahiro</creatorcontrib><creatorcontrib>Tanihara, Hidenobu</creatorcontrib><title>Elevated levels of multiple biomarkers of Alzheimer's disease in the aqueous humor of eyes with open-angle glaucoma</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description><![CDATA[To investigate levels of biomarkers of Alzheimer's disease in the aqueous humor in patients with open-angle glaucoma (OAG).
Aqueous humor samples were collected from 38 patients with cataracts, 20 patients with POAG, and 32 patients with exfoliation glaucoma. Aqueous levels of apolipoprotein (Apo) AI, ApoCIII, ApoE, transthyretin (TTR), complement factor H, complement C3, and α2-macroglobulin (α2M) were determined by multiplex bead immunoassay. Clinical data were obtained from medical charts.
Age and sex did not differ significantly among groups. POAG patients had significantly higher aqueous levels of Apo AI, ApoCIII, ApoE, TTR, and α2M compared with cataract patients (P < 0.001, P = 0.036, P < 0.001, P < 0.001, and P < 0.001, respectively). Corresponding values for exfoliation glaucoma patients were also significantly higher compared with those for cataract patients (P = 0.003, P = 0.009, P < 0.001, P < 0.001, and P < 0.001), and those levels correlated positively with each other in eyes with OAG (P < 0.001 for all combinations). Complement factor H and complement C3 levels did not differ among groups. Mean deviation values for the Humphrey visual field test correlated positively with levels of Apo AI, ApoE, TTR, and complement factor H in OAG patients (P = 0.026, 0.012, 0.008, and 0.027, respectively), but age and IOP values were not correlated with protein levels.
OAG patients had elevated levels of multiple biomarkers of Alzheimer's disease in the aqueous humor.]]></description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - complications</subject><subject>Alzheimer Disease - metabolism</subject><subject>Aqueous Humor - metabolism</subject><subject>Biomarkers - metabolism</subject><subject>Cross-Sectional Studies</subject><subject>Disease Progression</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Eye Proteins - metabolism</subject><subject>Female</subject><subject>Glaucoma, Open-Angle - complications</subject><subject>Glaucoma, Open-Angle - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Severity of Illness Index</subject><issn>1552-5783</issn><issn>1552-5783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkL1PwzAQxS0EolAYWZE3WFJ8dpOYsarKh1SJBWbLcc6NwUlKnBSVv56kLYjpne5-enr3CLkCNgFI0jtXb8IERAScT-MjcgZxzKM4leL43zwi5yG8M8YBODslIy5kwtJYnpGw8LjRLea0V_SB1paWnW_d2iPNXF3q5gOb3Xrmvwt0JTY3geYuoA5IXUXbAqn-7LDuAi26sm4GFrcY6JdrC1qvsYp0tertVl53pne8ICdW-4CXBx2Tt4fF6_wpWr48Ps9ny8gIwdsIJUtAS2u0McJIneepzS3PEqszAJMh5qAZTwWHKdgkNhbRiP4mtMk4l2JMbve-66buA4ZWlS4Y9F5XQ1oFU84gSeQ969Foj5qmDqFBq9aN63_fKmBq6FkNPSsQatdzz18frLusxPyP_i1W_AAhiXyx</recordid><startdate>20130809</startdate><enddate>20130809</enddate><creator>Inoue, Toshihiro</creator><creator>Kawaji, Takahiro</creator><creator>Tanihara, Hidenobu</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130809</creationdate><title>Elevated levels of multiple biomarkers of Alzheimer's disease in the aqueous humor of eyes with open-angle glaucoma</title><author>Inoue, Toshihiro ; Kawaji, Takahiro ; Tanihara, Hidenobu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-e8061a8fcacc3c8add7fdf2b6fab11cbeed1a02732141f65cfeec3ab13acb2283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - complications</topic><topic>Alzheimer Disease - metabolism</topic><topic>Aqueous Humor - metabolism</topic><topic>Biomarkers - metabolism</topic><topic>Cross-Sectional Studies</topic><topic>Disease Progression</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Eye Proteins - metabolism</topic><topic>Female</topic><topic>Glaucoma, Open-Angle - complications</topic><topic>Glaucoma, Open-Angle - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inoue, Toshihiro</creatorcontrib><creatorcontrib>Kawaji, Takahiro</creatorcontrib><creatorcontrib>Tanihara, Hidenobu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inoue, Toshihiro</au><au>Kawaji, Takahiro</au><au>Tanihara, Hidenobu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated levels of multiple biomarkers of Alzheimer's disease in the aqueous humor of eyes with open-angle glaucoma</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>2013-08-09</date><risdate>2013</risdate><volume>54</volume><issue>8</issue><spage>5353</spage><epage>5358</epage><pages>5353-5358</pages><issn>1552-5783</issn><eissn>1552-5783</eissn><abstract><![CDATA[To investigate levels of biomarkers of Alzheimer's disease in the aqueous humor in patients with open-angle glaucoma (OAG).
Aqueous humor samples were collected from 38 patients with cataracts, 20 patients with POAG, and 32 patients with exfoliation glaucoma. Aqueous levels of apolipoprotein (Apo) AI, ApoCIII, ApoE, transthyretin (TTR), complement factor H, complement C3, and α2-macroglobulin (α2M) were determined by multiplex bead immunoassay. Clinical data were obtained from medical charts.
Age and sex did not differ significantly among groups. POAG patients had significantly higher aqueous levels of Apo AI, ApoCIII, ApoE, TTR, and α2M compared with cataract patients (P < 0.001, P = 0.036, P < 0.001, P < 0.001, and P < 0.001, respectively). Corresponding values for exfoliation glaucoma patients were also significantly higher compared with those for cataract patients (P = 0.003, P = 0.009, P < 0.001, P < 0.001, and P < 0.001), and those levels correlated positively with each other in eyes with OAG (P < 0.001 for all combinations). Complement factor H and complement C3 levels did not differ among groups. Mean deviation values for the Humphrey visual field test correlated positively with levels of Apo AI, ApoE, TTR, and complement factor H in OAG patients (P = 0.026, 0.012, 0.008, and 0.027, respectively), but age and IOP values were not correlated with protein levels.
OAG patients had elevated levels of multiple biomarkers of Alzheimer's disease in the aqueous humor.]]></abstract><cop>United States</cop><pmid>23860758</pmid><doi>10.1167/iovs.13-12245</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Alzheimer Disease - complications Alzheimer Disease - metabolism Aqueous Humor - metabolism Biomarkers - metabolism Cross-Sectional Studies Disease Progression Enzyme-Linked Immunosorbent Assay Eye Proteins - metabolism Female Glaucoma, Open-Angle - complications Glaucoma, Open-Angle - metabolism Humans Male Middle Aged Severity of Illness Index |
| title | Elevated levels of multiple biomarkers of Alzheimer's disease in the aqueous humor of eyes with open-angle glaucoma |
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