Pharmacological disruption of mouse social approach behavior: Relevance to negative symptoms of schizophrenia

•Social approach behavior was not disrupted by NMDA antagonists.•The disruption induced by d-amphetamine was variable and was not reversed by antipsychotics.•The GABAA inverse agonist, FG-7142 induced a robust and reliable disruption of social behavior.•In line with clinical efficacy against negativ...

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Veröffentlicht in:	Behavioural brain research 2013-09, Vol.252, p.405-414
Hauptverfasser:	Hanks, Ashley N., Dlugolenski, Keith, Hughes, Zoë A., Seymour, Patricia A., Majchrzak, Mark J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Analysis of Variance Animals Antipyretics - therapeutic use Behavioral psychophysiology Biological and medical sciences Carbolines Carrier Proteins - genetics d-Cycloserine Dextroamphetamine - pharmacology Dopamine Uptake Inhibitors - pharmacology Dose-Response Relationship, Drug Excitatory Amino Acid Antagonists - toxicity Fundamental and applied biological sciences. Psychology GABA GABA Antagonists Male Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Mouse Negative symptom Nerve Tissue Proteins - genetics NMDA receptor Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Psychoses Receptors, N-Methyl-D-Aspartate Schizophrenia Social approach Social Behavior Disorders - chemically induced Social Behavior Disorders - drug therapy Social Behavior Disorders - genetics Time Factors
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