The use of alternative polyadenylation sites renders integrin β1 (Itgb1) mRNA isoforms with differential stability during mammary gland development

Integrins are heterodimeric cell-surface adhesion receptors that play a critical role in tissue development. Characterization of the full-length mRNA encoding the β1 subunit (Itgb1) revealed an alternative functional cleavage and polyadenylation site that yields a new Itgb1 mRNA isoform 578 bp short...

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Veröffentlicht in:	Biochemical journal 2013-09, Vol.454 (2), p.345-357
Hauptverfasser:	Naipauer, Julian, Gattelli, Albana, Degese, Maria Sol, Slomiansky, Victoria, Wertheimer, Eva, LaMarre, Jonathan, Castilla, Lucio, Abba, Martin, Kordon, Edith C, Coso, Omar A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Culture Techniques Cell Differentiation Cell Line Data Mining Female Gene Expression Regulation, Developmental Integrin beta1 - chemistry Integrin beta1 - genetics Integrin beta1 - metabolism Lactation - metabolism Mammary Glands, Animal - cytology Mammary Glands, Animal - growth & development Mammary Glands, Animal - metabolism Mice Mice, Inbred BALB C Polyadenylation Pregnancy Recombinant Proteins - chemistry Recombinant Proteins - metabolism RNA Isoforms - antagonists & inhibitors RNA Isoforms - metabolism RNA Processing, Post-Transcriptional RNA Stability RNA, Messenger - antagonists & inhibitors RNA, Messenger - metabolism RNA, Small Interfering Specific Pathogen-Free Organisms Weaning
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