Teratological assessment of five oxidative hair dyes in the rat
The oxidative dyes, 4,4′-diaminodiphenylene sulfate, N′-(2-hydroxyethyl)-4-nitro- O-phenylenediamine, N,N-dimethyl- p-phenylenediamine, 2,3-dihydroxynaphthalene, and resorcinol, were evaluated for teratogenic potential. Dyes were administered by gavage to pregnant Sprague-Dawley rats on gestation Da...
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| Veröffentlicht in: | Toxicology and applied pharmacology 1985-03, Vol.78 (1), p.163-166 |
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| creator | DiNardo, J.C. Picciano, J.C. Schnetzinger, R.W. Morris, W.E. Wolf, B.A. |
| description | The oxidative dyes, 4,4′-diaminodiphenylene sulfate,
N′-(2-hydroxyethyl)-4-nitro-
O-phenylenediamine,
N,N-dimethyl-
p-phenylenediamine, 2,3-dihydroxynaphthalene, and resorcinol, were evaluated for teratogenic potential. Dyes were administered by gavage to pregnant Sprague-Dawley rats on gestation Days 6 through 15 at doses ranging from 12.5 to 500 mg/kg. No overt signs of toxicity were observed during the treatment period. A significant reduction in mean maternal weight gain was noted during the treatment period at the high dose for 4,4′-diaminodiphenylene sulfate,
N′-(2-hydroxyethyl)-4-nitro-
O-phenylenediamine, and 2,3-dihydroxynaphthalene. The high dose for
N,N-dimethyl-
p-phenylenediamine and resorcinol, which exceeded a 100-fold exaggeration of human exposure, did not produce a significant reduction in maternal weight gain. An evaluation of fetal external, visceral, and skeletal anomalies revealed no statistically significant differences between dye-treated and vehicle control groups. Administration of 100,000 units of vitamin A, the positive control, on Day 9 of gestation resulted in a significant increase in abnormal fetuses. |
| doi_str_mv | 10.1016/0041-008X(85)90316-3 |
| format | Article |
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N′-(2-hydroxyethyl)-4-nitro-
O-phenylenediamine,
N,N-dimethyl-
p-phenylenediamine, 2,3-dihydroxynaphthalene, and resorcinol, were evaluated for teratogenic potential. Dyes were administered by gavage to pregnant Sprague-Dawley rats on gestation Days 6 through 15 at doses ranging from 12.5 to 500 mg/kg. No overt signs of toxicity were observed during the treatment period. A significant reduction in mean maternal weight gain was noted during the treatment period at the high dose for 4,4′-diaminodiphenylene sulfate,
N′-(2-hydroxyethyl)-4-nitro-
O-phenylenediamine, and 2,3-dihydroxynaphthalene. The high dose for
N,N-dimethyl-
p-phenylenediamine and resorcinol, which exceeded a 100-fold exaggeration of human exposure, did not produce a significant reduction in maternal weight gain. An evaluation of fetal external, visceral, and skeletal anomalies revealed no statistically significant differences between dye-treated and vehicle control groups. Administration of 100,000 units of vitamin A, the positive control, on Day 9 of gestation resulted in a significant increase in abnormal fetuses.</description><identifier>ISSN: 0041-008X</identifier><identifier>EISSN: 1096-0333</identifier><identifier>DOI: 10.1016/0041-008X(85)90316-3</identifier><identifier>PMID: 4035668</identifier><identifier>CODEN: TXAPA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Domestic and cosmetic products toxicology ; Dose-Response Relationship, Drug ; Female ; Hair Dyes - toxicity ; Hair Preparations - toxicity ; Medical sciences ; Oxidation-Reduction ; Phenylenediamines - toxicity ; Pregnancy ; Rats ; Rats, Inbred Strains ; Resorcinols - toxicity ; Teratogens ; Toxicology</subject><ispartof>Toxicology and applied pharmacology, 1985-03, Vol.78 (1), p.163-166</ispartof><rights>1985</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-300b07884a702028c7035b05204bf1ef6d3d6dac557d9e492be349b7bcf8e2223</citedby><cites>FETCH-LOGICAL-c332t-300b07884a702028c7035b05204bf1ef6d3d6dac557d9e492be349b7bcf8e2223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0041-008X(85)90316-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9222798$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4035668$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DiNardo, J.C.</creatorcontrib><creatorcontrib>Picciano, J.C.</creatorcontrib><creatorcontrib>Schnetzinger, R.W.</creatorcontrib><creatorcontrib>Morris, W.E.</creatorcontrib><creatorcontrib>Wolf, B.A.</creatorcontrib><title>Teratological assessment of five oxidative hair dyes in the rat</title><title>Toxicology and applied pharmacology</title><addtitle>Toxicol Appl Pharmacol</addtitle><description>The oxidative dyes, 4,4′-diaminodiphenylene sulfate,
N′-(2-hydroxyethyl)-4-nitro-
O-phenylenediamine,
N,N-dimethyl-
p-phenylenediamine, 2,3-dihydroxynaphthalene, and resorcinol, were evaluated for teratogenic potential. Dyes were administered by gavage to pregnant Sprague-Dawley rats on gestation Days 6 through 15 at doses ranging from 12.5 to 500 mg/kg. No overt signs of toxicity were observed during the treatment period. A significant reduction in mean maternal weight gain was noted during the treatment period at the high dose for 4,4′-diaminodiphenylene sulfate,
N′-(2-hydroxyethyl)-4-nitro-
O-phenylenediamine, and 2,3-dihydroxynaphthalene. The high dose for
N,N-dimethyl-
p-phenylenediamine and resorcinol, which exceeded a 100-fold exaggeration of human exposure, did not produce a significant reduction in maternal weight gain. An evaluation of fetal external, visceral, and skeletal anomalies revealed no statistically significant differences between dye-treated and vehicle control groups. Administration of 100,000 units of vitamin A, the positive control, on Day 9 of gestation resulted in a significant increase in abnormal fetuses.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Domestic and cosmetic products toxicology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Hair Dyes - toxicity</subject><subject>Hair Preparations - toxicity</subject><subject>Medical sciences</subject><subject>Oxidation-Reduction</subject><subject>Phenylenediamines - toxicity</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Resorcinols - toxicity</subject><subject>Teratogens</subject><subject>Toxicology</subject><issn>0041-008X</issn><issn>1096-0333</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo67r6DxR6ENFDddKkbXJRZPELFrys4C2kydSNdFtNuov7723dskdPMzDPO7w8hJxSuKZAsxsATmMA8X4p0isJjGYx2yNjCjKLgTG2T8Y75JAchfAJAJJzOiIjDizNMjEmd3P0um2q5sMZXUU6BAxhiXUbNWVUujVGzY-zuu23hXY-shsMkaujdoFRlzwmB6WuAp4Mc0LeHh_m0-d49vr0Mr2fxYaxpI0ZQAG5EFznkEAiTN4VKCBNgBclxTKzzGZWmzTNrUQukwIZl0VemFJgkiRsQi62f798873C0KqlCwarStfYrIKinMqMCdmBfAsa34TgsVRf3i213ygKqvemeimql6JEqv68KdbFzob_q2KJdhcaRHX38-GuQyeq9Lo2Luww2XXMZY_dbjHsXKwdehWMw9qgdR5Nq2zj_u_xC-Y_iC8</recordid><startdate>19850330</startdate><enddate>19850330</enddate><creator>DiNardo, J.C.</creator><creator>Picciano, J.C.</creator><creator>Schnetzinger, R.W.</creator><creator>Morris, W.E.</creator><creator>Wolf, B.A.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19850330</creationdate><title>Teratological assessment of five oxidative hair dyes in the rat</title><author>DiNardo, J.C. ; Picciano, J.C. ; Schnetzinger, R.W. ; Morris, W.E. ; Wolf, B.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-300b07884a702028c7035b05204bf1ef6d3d6dac557d9e492be349b7bcf8e2223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Domestic and cosmetic products toxicology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Hair Dyes - toxicity</topic><topic>Hair Preparations - toxicity</topic><topic>Medical sciences</topic><topic>Oxidation-Reduction</topic><topic>Phenylenediamines - toxicity</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Resorcinols - toxicity</topic><topic>Teratogens</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DiNardo, J.C.</creatorcontrib><creatorcontrib>Picciano, J.C.</creatorcontrib><creatorcontrib>Schnetzinger, R.W.</creatorcontrib><creatorcontrib>Morris, W.E.</creatorcontrib><creatorcontrib>Wolf, B.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicology and applied pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DiNardo, J.C.</au><au>Picciano, J.C.</au><au>Schnetzinger, R.W.</au><au>Morris, W.E.</au><au>Wolf, B.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Teratological assessment of five oxidative hair dyes in the rat</atitle><jtitle>Toxicology and applied pharmacology</jtitle><addtitle>Toxicol Appl Pharmacol</addtitle><date>1985-03-30</date><risdate>1985</risdate><volume>78</volume><issue>1</issue><spage>163</spage><epage>166</epage><pages>163-166</pages><issn>0041-008X</issn><eissn>1096-0333</eissn><coden>TXAPA9</coden><abstract>The oxidative dyes, 4,4′-diaminodiphenylene sulfate,
N′-(2-hydroxyethyl)-4-nitro-
O-phenylenediamine,
N,N-dimethyl-
p-phenylenediamine, 2,3-dihydroxynaphthalene, and resorcinol, were evaluated for teratogenic potential. Dyes were administered by gavage to pregnant Sprague-Dawley rats on gestation Days 6 through 15 at doses ranging from 12.5 to 500 mg/kg. No overt signs of toxicity were observed during the treatment period. A significant reduction in mean maternal weight gain was noted during the treatment period at the high dose for 4,4′-diaminodiphenylene sulfate,
N′-(2-hydroxyethyl)-4-nitro-
O-phenylenediamine, and 2,3-dihydroxynaphthalene. The high dose for
N,N-dimethyl-
p-phenylenediamine and resorcinol, which exceeded a 100-fold exaggeration of human exposure, did not produce a significant reduction in maternal weight gain. An evaluation of fetal external, visceral, and skeletal anomalies revealed no statistically significant differences between dye-treated and vehicle control groups. Administration of 100,000 units of vitamin A, the positive control, on Day 9 of gestation resulted in a significant increase in abnormal fetuses.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>4035668</pmid><doi>10.1016/0041-008X(85)90316-3</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Toxicology and applied pharmacology, 1985-03, Vol.78 (1), p.163-166 |
| issn | 0041-008X 1096-0333 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_14196389 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Biological and medical sciences Domestic and cosmetic products toxicology Dose-Response Relationship, Drug Female Hair Dyes - toxicity Hair Preparations - toxicity Medical sciences Oxidation-Reduction Phenylenediamines - toxicity Pregnancy Rats Rats, Inbred Strains Resorcinols - toxicity Teratogens Toxicology |
| title | Teratological assessment of five oxidative hair dyes in the rat |
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