Glial proliferation after vitrectomy for a macular hole: a spectral domain optical coherence tomography study
Purpose To characterize eyes with glial proliferation after macular hole (MH) surgery. Methods We retrospectively reviewed patients who underwent vitrectomy for an idiopathic MH using spectral domain optical coherence tomography (SD-OCT). The pattern of the closed MH after surgery was categorized ac...
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| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 2013-02, Vol.251 (2), p.477-484 |
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| creator | Oh, Jaeryung Yang, Sun Mo Choi, Yong Min Kim, Seong-Woo Huh, Kuhl |
| description | Purpose
To characterize eyes with glial proliferation after macular hole (MH) surgery.
Methods
We retrospectively reviewed patients who underwent vitrectomy for an idiopathic MH using spectral domain optical coherence tomography (SD-OCT). The pattern of the closed MH after surgery was categorized according to the presence (group 1) or absence (group 2) of apparent glial proliferation, which was determined by glial tissue reflectivity involving the external limiting membrane (ELM) and photoreceptor layers. Photoreceptor layer defect areas were categorized as mild or severe. Best-corrected visual acuity (BCVA) and pre- and postoperative OCT parameters were compared between the two groups.
Results
Among 30 eyes followed-up for a median of 11 months, seven (23 %) were assigned to group 1 and 23 (77 %) to group 2. The median age was higher in group 1 (70 years) than in group 2 (63 years). The postoperative BCVA was poorer in group 1 than in group 2 at 3 months and at the final examination (
P
= 0.022 and
P
|
| doi_str_mv | 10.1007/s00417-012-2058-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1419373640</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2883804021</sourcerecordid><originalsourceid>FETCH-LOGICAL-c471t-8d90f4420ee28503c586d7a48d1fb16dacc93ef82f6c11b376b3a3a5f04190603</originalsourceid><addsrcrecordid>eNqNkU1r3DAQhkVpaTZJf0AvRdBLLk41kvXh3ErIFwR6aSA3oZVHWQfbciU7sP8-WjYpJVDIaRjmed_R6CXkK7BTYEz_yIzVoCsGvOJMmqr5QFZQC1lpxu8_khXTHCoj-P0BOcz5kRVcSPhMDjhXXADIFRmu-s71dEqx7wImN3dxpC7MmOhTNyf0cxy2NMREHR2cX3qX6Cb2eFb6PJVxKuo2Dq4baZzmzpfWxw0mHD3SIo4PyU2bLc3z0m6Pyafg-oxfXuoRubu8-H1-Xd3-uro5_3lb-VrDXJm2YaGuOUPkRjLhpVGtdrVpIaxBtc77RmAwPCgPsBZarYUTTobyHQ1TTByRk71vuevPgnm2Q5c99r0bMS7ZQuGEFqp-B7p7gQGjZEG_v0Ef45LGcsiOqrkyWqpCwZ7yKeacMNgpdYNLWwvM7mKz-9hsic3uYrNN0Xx7cV7WA7Z_Fa85FYDvgVxG4wOmf1b_1_UZolOing</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1284268756</pqid></control><display><type>article</type><title>Glial proliferation after vitrectomy for a macular hole: a spectral domain optical coherence tomography study</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Oh, Jaeryung ; Yang, Sun Mo ; Choi, Yong Min ; Kim, Seong-Woo ; Huh, Kuhl</creator><creatorcontrib>Oh, Jaeryung ; Yang, Sun Mo ; Choi, Yong Min ; Kim, Seong-Woo ; Huh, Kuhl</creatorcontrib><description>Purpose
To characterize eyes with glial proliferation after macular hole (MH) surgery.
Methods
We retrospectively reviewed patients who underwent vitrectomy for an idiopathic MH using spectral domain optical coherence tomography (SD-OCT). The pattern of the closed MH after surgery was categorized according to the presence (group 1) or absence (group 2) of apparent glial proliferation, which was determined by glial tissue reflectivity involving the external limiting membrane (ELM) and photoreceptor layers. Photoreceptor layer defect areas were categorized as mild or severe. Best-corrected visual acuity (BCVA) and pre- and postoperative OCT parameters were compared between the two groups.
Results
Among 30 eyes followed-up for a median of 11 months, seven (23 %) were assigned to group 1 and 23 (77 %) to group 2. The median age was higher in group 1 (70 years) than in group 2 (63 years). The postoperative BCVA was poorer in group 1 than in group 2 at 3 months and at the final examination (
P
= 0.022 and
P
< 0.001 respectively). The median preoperative basal hole diameter in group 1 (1,219 μm) was larger than that of group 2 (590 μm) (
P
= 0.002). The MH index (hole height/basal hole diameter) was smaller in group 1 than in group 2 (
P
= 0.012). At the final examination, group 1 had larger mild and severe photoreceptor layer defect areas (medians 1,300 μm and 207 μm respectively) than group 2 (medians 110 μm and 70 μm respectively) (
P
< 0.001 and
P
< 0.001 respectively).
Conclusions
Eyes with glial proliferation after surgery for MH had different preoperative characteristics than eyes with no evidence of glial proliferation. In addition to a large hole diameter, other factors such as a small MH index and advanced age could be involved in the development of glial proliferation.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-012-2058-9</identifier><identifier>PMID: 22623115</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Aged ; Cell Proliferation ; Epiretinal Membrane ; Female ; Follow-Up Studies ; Gliosis - diagnosis ; Gliosis - etiology ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neuroglia - pathology ; Ophthalmology ; Postoperative Complications ; Retinal Disorders ; Retinal Perforations - surgery ; Retrospective Studies ; Tomography, Optical Coherence ; Visual Acuity - physiology ; Vitrectomy</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2013-02, Vol.251 (2), p.477-484</ispartof><rights>Springer-Verlag 2012</rights><rights>Springer-Verlag Berlin Heidelberg 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-8d90f4420ee28503c586d7a48d1fb16dacc93ef82f6c11b376b3a3a5f04190603</citedby><cites>FETCH-LOGICAL-c471t-8d90f4420ee28503c586d7a48d1fb16dacc93ef82f6c11b376b3a3a5f04190603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00417-012-2058-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00417-012-2058-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22623115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oh, Jaeryung</creatorcontrib><creatorcontrib>Yang, Sun Mo</creatorcontrib><creatorcontrib>Choi, Yong Min</creatorcontrib><creatorcontrib>Kim, Seong-Woo</creatorcontrib><creatorcontrib>Huh, Kuhl</creatorcontrib><title>Glial proliferation after vitrectomy for a macular hole: a spectral domain optical coherence tomography study</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
To characterize eyes with glial proliferation after macular hole (MH) surgery.
Methods
We retrospectively reviewed patients who underwent vitrectomy for an idiopathic MH using spectral domain optical coherence tomography (SD-OCT). The pattern of the closed MH after surgery was categorized according to the presence (group 1) or absence (group 2) of apparent glial proliferation, which was determined by glial tissue reflectivity involving the external limiting membrane (ELM) and photoreceptor layers. Photoreceptor layer defect areas were categorized as mild or severe. Best-corrected visual acuity (BCVA) and pre- and postoperative OCT parameters were compared between the two groups.
Results
Among 30 eyes followed-up for a median of 11 months, seven (23 %) were assigned to group 1 and 23 (77 %) to group 2. The median age was higher in group 1 (70 years) than in group 2 (63 years). The postoperative BCVA was poorer in group 1 than in group 2 at 3 months and at the final examination (
P
= 0.022 and
P
< 0.001 respectively). The median preoperative basal hole diameter in group 1 (1,219 μm) was larger than that of group 2 (590 μm) (
P
= 0.002). The MH index (hole height/basal hole diameter) was smaller in group 1 than in group 2 (
P
= 0.012). At the final examination, group 1 had larger mild and severe photoreceptor layer defect areas (medians 1,300 μm and 207 μm respectively) than group 2 (medians 110 μm and 70 μm respectively) (
P
< 0.001 and
P
< 0.001 respectively).
Conclusions
Eyes with glial proliferation after surgery for MH had different preoperative characteristics than eyes with no evidence of glial proliferation. In addition to a large hole diameter, other factors such as a small MH index and advanced age could be involved in the development of glial proliferation.</description><subject>Aged</subject><subject>Cell Proliferation</subject><subject>Epiretinal Membrane</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gliosis - diagnosis</subject><subject>Gliosis - etiology</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neuroglia - pathology</subject><subject>Ophthalmology</subject><subject>Postoperative Complications</subject><subject>Retinal Disorders</subject><subject>Retinal Perforations - surgery</subject><subject>Retrospective Studies</subject><subject>Tomography, Optical Coherence</subject><subject>Visual Acuity - physiology</subject><subject>Vitrectomy</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkU1r3DAQhkVpaTZJf0AvRdBLLk41kvXh3ErIFwR6aSA3oZVHWQfbciU7sP8-WjYpJVDIaRjmed_R6CXkK7BTYEz_yIzVoCsGvOJMmqr5QFZQC1lpxu8_khXTHCoj-P0BOcz5kRVcSPhMDjhXXADIFRmu-s71dEqx7wImN3dxpC7MmOhTNyf0cxy2NMREHR2cX3qX6Cb2eFb6PJVxKuo2Dq4baZzmzpfWxw0mHD3SIo4PyU2bLc3z0m6Pyafg-oxfXuoRubu8-H1-Xd3-uro5_3lb-VrDXJm2YaGuOUPkRjLhpVGtdrVpIaxBtc77RmAwPCgPsBZarYUTTobyHQ1TTByRk71vuevPgnm2Q5c99r0bMS7ZQuGEFqp-B7p7gQGjZEG_v0Ef45LGcsiOqrkyWqpCwZ7yKeacMNgpdYNLWwvM7mKz-9hsic3uYrNN0Xx7cV7WA7Z_Fa85FYDvgVxG4wOmf1b_1_UZolOing</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Oh, Jaeryung</creator><creator>Yang, Sun Mo</creator><creator>Choi, Yong Min</creator><creator>Kim, Seong-Woo</creator><creator>Huh, Kuhl</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20130201</creationdate><title>Glial proliferation after vitrectomy for a macular hole: a spectral domain optical coherence tomography study</title><author>Oh, Jaeryung ; Yang, Sun Mo ; Choi, Yong Min ; Kim, Seong-Woo ; Huh, Kuhl</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-8d90f4420ee28503c586d7a48d1fb16dacc93ef82f6c11b376b3a3a5f04190603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Cell Proliferation</topic><topic>Epiretinal Membrane</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gliosis - diagnosis</topic><topic>Gliosis - etiology</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neuroglia - pathology</topic><topic>Ophthalmology</topic><topic>Postoperative Complications</topic><topic>Retinal Disorders</topic><topic>Retinal Perforations - surgery</topic><topic>Retrospective Studies</topic><topic>Tomography, Optical Coherence</topic><topic>Visual Acuity - physiology</topic><topic>Vitrectomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oh, Jaeryung</creatorcontrib><creatorcontrib>Yang, Sun Mo</creatorcontrib><creatorcontrib>Choi, Yong Min</creatorcontrib><creatorcontrib>Kim, Seong-Woo</creatorcontrib><creatorcontrib>Huh, Kuhl</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oh, Jaeryung</au><au>Yang, Sun Mo</au><au>Choi, Yong Min</au><au>Kim, Seong-Woo</au><au>Huh, Kuhl</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glial proliferation after vitrectomy for a macular hole: a spectral domain optical coherence tomography study</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>251</volume><issue>2</issue><spage>477</spage><epage>484</epage><pages>477-484</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Purpose
To characterize eyes with glial proliferation after macular hole (MH) surgery.
Methods
We retrospectively reviewed patients who underwent vitrectomy for an idiopathic MH using spectral domain optical coherence tomography (SD-OCT). The pattern of the closed MH after surgery was categorized according to the presence (group 1) or absence (group 2) of apparent glial proliferation, which was determined by glial tissue reflectivity involving the external limiting membrane (ELM) and photoreceptor layers. Photoreceptor layer defect areas were categorized as mild or severe. Best-corrected visual acuity (BCVA) and pre- and postoperative OCT parameters were compared between the two groups.
Results
Among 30 eyes followed-up for a median of 11 months, seven (23 %) were assigned to group 1 and 23 (77 %) to group 2. The median age was higher in group 1 (70 years) than in group 2 (63 years). The postoperative BCVA was poorer in group 1 than in group 2 at 3 months and at the final examination (
P
= 0.022 and
P
< 0.001 respectively). The median preoperative basal hole diameter in group 1 (1,219 μm) was larger than that of group 2 (590 μm) (
P
= 0.002). The MH index (hole height/basal hole diameter) was smaller in group 1 than in group 2 (
P
= 0.012). At the final examination, group 1 had larger mild and severe photoreceptor layer defect areas (medians 1,300 μm and 207 μm respectively) than group 2 (medians 110 μm and 70 μm respectively) (
P
< 0.001 and
P
< 0.001 respectively).
Conclusions
Eyes with glial proliferation after surgery for MH had different preoperative characteristics than eyes with no evidence of glial proliferation. In addition to a large hole diameter, other factors such as a small MH index and advanced age could be involved in the development of glial proliferation.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22623115</pmid><doi>10.1007/s00417-012-2058-9</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 2013-02, Vol.251 (2), p.477-484 |
| issn | 0721-832X 1435-702X |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Aged Cell Proliferation Epiretinal Membrane Female Follow-Up Studies Gliosis - diagnosis Gliosis - etiology Humans Male Medicine Medicine & Public Health Middle Aged Neuroglia - pathology Ophthalmology Postoperative Complications Retinal Disorders Retinal Perforations - surgery Retrospective Studies Tomography, Optical Coherence Visual Acuity - physiology Vitrectomy |
| title | Glial proliferation after vitrectomy for a macular hole: a spectral domain optical coherence tomography study |
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