Lipoxygenase inhibitor MK886 potentiates TRAIL-induced apoptosis through CHOP- and p38 MAPK-mediated up-regulation of death receptor 5 in malignant glioma

► MK886 sensitizes glioma cells to TRAIL-mediated apoptosis via upregulation of DR5. ► Upregulation of DR5 induced by MK886 is regulated by p38 MAPK. ► Knockdown of p38 MAPK blocks DR5 upregulation and TRAIL-induced apoptosis. ► MK886-induced TRAIL sensitization is independent of ROS. Tumor necrosis...

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Veröffentlicht in:	Biochemical and biophysical research communications 2013-02, Vol.431 (2), p.354-359
Hauptverfasser:	Woo, Ji Sun, Kim, Seong Muk, Jeong, Chang Hyun, Ryu, Chung Heon, Jeun, Sin-Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Death receptor Drug Resistance, Neoplasm - drug effects Drug Synergism Gene Knockdown Techniques Glioma Glioma - metabolism Humans Indoles - pharmacology Lipoxygenase inhibitor Lipoxygenase Inhibitors - pharmacology Mesenchymal stem cells p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism Receptors, TNF-Related Apoptosis-Inducing Ligand - biosynthesis TNF-Related Apoptosis-Inducing Ligand - pharmacology TRAIL Transcription Factor CHOP - genetics Transcription Factor CHOP - metabolism Up-Regulation
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