Central Nervous System Involvement in the Animal Model of Myodystrophy

Congenital muscular dystrophies present mutated gene in the LARGE mice model and it is characterized by an abnormal glycosylation of α-dystroglycan (α-DG), strongly implicated as having a causative role in the development of central nervous system abnormalities such as cognitive impairment seen in p...

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Veröffentlicht in:	Molecular neurobiology 2013-08, Vol.48 (1), p.71-77
Hauptverfasser:	Comim, Clarissa M., Mendonça, Bruna P., Dominguini, Diogo, Cipriano, Andreza L., Steckert, Amanda V., Scaini, Giselli, Vainzof, Mariz, Streck, Emílio L., Dal-Pizzol, Felipe, Quevedo, João
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Avoidance Learning Behavior, Animal Biomedical and Life Sciences Biomedicine Brain-Derived Neurotrophic Factor - metabolism Cell Biology Central Nervous System - metabolism Central Nervous System - pathology Congenital diseases Disease Models, Animal Electron Transport Energy Metabolism Mice Muscular Dystrophies - metabolism Muscular Dystrophies - pathology Nervous system Neurobiology Neurology Neurosciences Oxidation-Reduction Oxidative Stress
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