CXCL12-Mediated Murine Neural Progenitor Cell Movement Requires PI3Kβ Activation

The migratory route of neural progenitor/precursor cells (NPC) has a central role in central nervous system development. Although the role of the chemokine CXCL12 in NPC migration has been described, the intracellular signaling cascade involved remains largely unclear. Here we studied the molecular...

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Veröffentlicht in:	Molecular neurobiology 2013-08, Vol.48 (1), p.217-231
Hauptverfasser:	Holgado, Borja L., Martínez-Muñoz, Laura, Sánchez-Alcañiz, Juan Antonio, Lucas, Pilar, Pérez-García, Vicente, Pérez, Gema, Rodríguez-Frade, José Miguel, Nieto, Marta, Marín, Óscar, Carrasco, Yolanda R., Carrera, Ana C., Álvarez-Dolado, Manuel, Mellado, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Animals Biomedical and Life Sciences Biomedicine Cell Biology Cell Movement - drug effects Chemokine CXCL12 - pharmacology Class I Phosphatidylinositol 3-Kinases - metabolism Enzyme Activation - drug effects Interneurons - cytology Interneurons - drug effects Interneurons - enzymology Janus Kinases - metabolism Mice Neural Stem Cells - cytology Neural Stem Cells - drug effects Neural Stem Cells - enzymology Neurobiology Neurology Neurosciences Pyramidal Cells - cytology Pyramidal Cells - drug effects Pyramidal Cells - enzymology Signal Transduction - drug effects Spheroids, Cellular - cytology Spheroids, Cellular - drug effects Spheroids, Cellular - metabolism STAT Transcription Factors - metabolism
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