Influence of various factors on DNA methylation in a group of elderly individuals

Influence of various factors on DNA methylation in a group of elderly individuals

In a group of 194 persons aged 54-86 years global DNA methylation was determined using Imprint DNA Quantification Kit MDQ1 (Sigma-Aldrich). The association with several biochemical factors as serum glucose, serum creatinine and folic acid (determined by chemiluminescence) levels as well as with sex,...

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Veröffentlicht in:Acta neurobiologiae experimentalis 2013-01, Vol.73 (1), p.186-187
Hauptverfasser: Graban, A, Bednarska-Makaruk, M, Bochynska, A, Lojkowska, W, Mitchell, M, Ryglewicz, D, Sobczynska-Malefora, A, Wehr, H
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container_title Acta neurobiologiae experimentalis
container_volume 73
creator Graban, A
Bednarska-Makaruk, M
Bochynska, A
Lojkowska, W
Mitchell, M
Ryglewicz, D
Sobczynska-Malefora, A
Wehr, H
description In a group of 194 persons aged 54-86 years global DNA methylation was determined using Imprint DNA Quantification Kit MDQ1 (Sigma-Aldrich). The association with several biochemical factors as serum glucose, serum creatinine and folic acid (determined by chemiluminescence) levels as well as with sex, age and cognitive status was estimated by multivariate stepwise regression analysis. The strongest association was stated with serum creatinine (P=0.0003), with serum folic acid (P=0.005) and with glucose (0.008) levels. The mechanisms and significance of these associations is discussed in view of human aging and age-connected diseases as atherosclerosis, diabetes and renal failure.
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title Influence of various factors on DNA methylation in a group of elderly individuals
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