Novel contribution of cell surface and intracellular M1‐muscarinic acetylcholine receptors to synaptic plasticity in hippocampus

Muscarinic acetylcholine receptors (mAChRs) are well known to transmit extracellular cholinergic signals into the cytoplasm from their position on the cell surface. However, we show here that M1‐mAChRs are also highly expressed on intracellular membranes in neurons of the telencephalon and activate...

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Veröffentlicht in:	Journal of neurochemistry 2013-08, Vol.126 (3), p.360-371
Hauptverfasser:	Anisuzzaman, Abu Syed Md, Uwada, Junsuke, Masuoka, Takayoshi, Yoshiki, Hatsumi, Nishio, Matomo, Ikegaya, Yuji, Takahashi, Naoya, Matsuki, Norio, Fujibayashi, Yasuhisa, Yonekura, Yoshiharu, Momiyama, Toshihiko, Muramatsu, Ikunobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Animals Blotting, Western Cell Membrane - chemistry Cell Membrane - metabolism cell surface and intracellular GPCR Cytoplasm - chemistry Cytoplasm - metabolism ERK1/2 Female Hippocampus - metabolism Humans Immunohistochemistry LTP M1‐muscarinic receptor Male Mice Mice, Inbred C57BL Mice, Knockout Middle Aged Neurochemistry Neuronal Plasticity - physiology Neurons Neurons - metabolism Patch-Clamp Techniques Phosphorylation Rats Rats, Wistar Receptor, Muscarinic M1 - metabolism Rodents Synapses - metabolism synaptic plasticity Synaptic Transmission - physiology
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