Up-regulation of astroglial heme oxygenase-1 by a synthetic (S)-verbenone derivative LMT-335 ameliorates oxygen–glucose deprivation-evoked injury in cortical neurons

► LMT-335 is a novel synthetic antioxidant designed as an anti-ischemic agent. ► LMT-335 protected neurons from oxygen–glucose deprivation and reoxygenation. ► LMT-335 reduced OGD/R-evoked oxidative stress by enhancing astroglial HO-1 proteins. ► HO-1 inhibitor SnPP abolished the neuroprotective eff...

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Veröffentlicht in:	Biochemical and biophysical research communications 2013-02, Vol.431 (3), p.484-489
Hauptverfasser:	Ju, Chung, Song, Sumi, Kim, Minkyoung, Choi, Yongseok, Kim, Won-Ki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - enzymology Astroglia Benzylidene Compounds - chemistry Benzylidene Compounds - pharmacology Cells, Cultured Cerebral Cortex - drug effects Cerebral Cortex - enzymology Cerebral Cortex - pathology Cerebral ischemia Cyclohexanones - chemistry Cyclohexanones - pharmacology Glucose - deficiency Heme Oxygenase-1 - biosynthesis Heme-oxygenase-1 LMT-335 Neurons - drug effects Neurons - pathology Neuroprotective Agents - pharmacology Oxidative stress Oxygen - metabolism Oxygen–glucose deprivation/re-oxygenation Rats Rats, Sprague-Dawley Terpenes - chemistry Terpenes - pharmacology Up-Regulation
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