Shared dysregulated pathways lead to Parkinson's disease and diabetes
Recent evidence indicates that Parkinson's disease and diabetes, both age-related chronic diseases, share remarkably similar dysregulated pathways. Exposure to environmental factors and genetic susceptibility play a role in the etiology and progression of both diseases. In light of recent findi...
Gespeichert in:
| Veröffentlicht in: | Trends in molecular medicine 2013-03, Vol.19 (3), p.176-186 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 186 |
|---|---|
| container_issue | 3 |
| container_start_page | 176 |
| container_title | Trends in molecular medicine |
| container_volume | 19 |
| creator | Santiago, Jose A Potashkin, Judith A |
| description | Recent evidence indicates that Parkinson's disease and diabetes, both age-related chronic diseases, share remarkably similar dysregulated pathways. Exposure to environmental factors and genetic susceptibility play a role in the etiology and progression of both diseases. In light of recent findings, an intriguing hypothesis has emerged that suggests that mitochondrial dysfunction, endoplasmic reticulum stress, inflammation, and alterations in metabolism may lead to insulin resistance and, ultimately, to diabetes and/or neurodegeneration. In this article, we summarize the studies that have addressed the relationship between Parkinson's disease and diabetes and propose that disruptions in these shared molecular networks lead to both chronic diseases. |
| doi_str_mv | 10.1016/j.molmed.2013.01.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1419369947</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S147149141300004X</els_id><sourcerecordid>1419369947</sourcerecordid><originalsourceid>FETCH-LOGICAL-c516t-215369c742ef88d80c6027f4182ee4d43c854c04d2ad43732a0a4ff5e286a5f63</originalsourceid><addsrcrecordid>eNqFkU1P3DAQhq2qFd__oKpyay-bevwRJxekCtGChAQSIHGzBntSvGSTrZ2A9t_X0QIHLszFM_L7zis9w9hX4CVwqH4uy9XQrciXgoMsOZSci09sD5SBhWqau89vPahdtp_SknPQxtQ7bFdIaXRt5B47vX7ASL7wmxTp79ThmIc1jg_PuElFR-iLcSiuMD6GPg3991T4kAgTFdhnV8B7Gikdsi8tdomOXt4Ddvv79ObkbHFx-ef85NfFwmmoxoUALavGGSWorWtfc1dxYVoFtSBSXklXa-W48gLzYKRAjqptNYm6Qt1W8oD92O5dx-HfRGm0q5AcdR32NEzJgoImJzTKfCyVUHFdad1kqdpKXRxSxtDadQwrjBsL3M6s7dJuWduZteVgM-ts-_aSMN3Pf6-mV7hZcLwVUEbyFCja5AL1jnyI5Ebrh_BRwvsFrgt9cNg90obScphin3FbsElYbq_ne8_nBslzqTv5HxsVpTI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1316056559</pqid></control><display><type>article</type><title>Shared dysregulated pathways lead to Parkinson's disease and diabetes</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Santiago, Jose A ; Potashkin, Judith A</creator><creatorcontrib>Santiago, Jose A ; Potashkin, Judith A</creatorcontrib><description>Recent evidence indicates that Parkinson's disease and diabetes, both age-related chronic diseases, share remarkably similar dysregulated pathways. Exposure to environmental factors and genetic susceptibility play a role in the etiology and progression of both diseases. In light of recent findings, an intriguing hypothesis has emerged that suggests that mitochondrial dysfunction, endoplasmic reticulum stress, inflammation, and alterations in metabolism may lead to insulin resistance and, ultimately, to diabetes and/or neurodegeneration. In this article, we summarize the studies that have addressed the relationship between Parkinson's disease and diabetes and propose that disruptions in these shared molecular networks lead to both chronic diseases.</description><identifier>ISSN: 1471-4914</identifier><identifier>EISSN: 1471-499X</identifier><identifier>DOI: 10.1016/j.molmed.2013.01.002</identifier><identifier>PMID: 23375873</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Biomarkers - blood ; Blood Glucose - analysis ; Chronic Disease ; diabetes ; Diabetes Mellitus - genetics ; Diabetes Mellitus - physiopathology ; Disease Progression ; Endoplasmic Reticulum Stress ; Genetic Predisposition to Disease ; Homeostasis ; Humans ; Inflammation - genetics ; Inflammation - physiopathology ; insulin resistance ; Insulin Resistance - genetics ; Insulin-Like Growth Factor I - genetics ; Insulin-Like Growth Factor I - metabolism ; Mitochondria - metabolism ; neurodegeneration ; Parkinson Disease - genetics ; Parkinson Disease - physiopathology ; Parkinson's disease ; Pathology ; Transcription Factors ; Vitamin D - pharmacology</subject><ispartof>Trends in molecular medicine, 2013-03, Vol.19 (3), p.176-186</ispartof><rights>Elsevier Ltd</rights><rights>2013 Elsevier Ltd</rights><rights>Copyright © 2013 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-215369c742ef88d80c6027f4182ee4d43c854c04d2ad43732a0a4ff5e286a5f63</citedby><cites>FETCH-LOGICAL-c516t-215369c742ef88d80c6027f4182ee4d43c854c04d2ad43732a0a4ff5e286a5f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.molmed.2013.01.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23375873$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Santiago, Jose A</creatorcontrib><creatorcontrib>Potashkin, Judith A</creatorcontrib><title>Shared dysregulated pathways lead to Parkinson's disease and diabetes</title><title>Trends in molecular medicine</title><addtitle>Trends Mol Med</addtitle><description>Recent evidence indicates that Parkinson's disease and diabetes, both age-related chronic diseases, share remarkably similar dysregulated pathways. Exposure to environmental factors and genetic susceptibility play a role in the etiology and progression of both diseases. In light of recent findings, an intriguing hypothesis has emerged that suggests that mitochondrial dysfunction, endoplasmic reticulum stress, inflammation, and alterations in metabolism may lead to insulin resistance and, ultimately, to diabetes and/or neurodegeneration. In this article, we summarize the studies that have addressed the relationship between Parkinson's disease and diabetes and propose that disruptions in these shared molecular networks lead to both chronic diseases.</description><subject>Animals</subject><subject>Biomarkers - blood</subject><subject>Blood Glucose - analysis</subject><subject>Chronic Disease</subject><subject>diabetes</subject><subject>Diabetes Mellitus - genetics</subject><subject>Diabetes Mellitus - physiopathology</subject><subject>Disease Progression</subject><subject>Endoplasmic Reticulum Stress</subject><subject>Genetic Predisposition to Disease</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Inflammation - genetics</subject><subject>Inflammation - physiopathology</subject><subject>insulin resistance</subject><subject>Insulin Resistance - genetics</subject><subject>Insulin-Like Growth Factor I - genetics</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Mitochondria - metabolism</subject><subject>neurodegeneration</subject><subject>Parkinson Disease - genetics</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson's disease</subject><subject>Pathology</subject><subject>Transcription Factors</subject><subject>Vitamin D - pharmacology</subject><issn>1471-4914</issn><issn>1471-499X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1P3DAQhq2qFd__oKpyay-bevwRJxekCtGChAQSIHGzBntSvGSTrZ2A9t_X0QIHLszFM_L7zis9w9hX4CVwqH4uy9XQrciXgoMsOZSci09sD5SBhWqau89vPahdtp_SknPQxtQ7bFdIaXRt5B47vX7ASL7wmxTp79ThmIc1jg_PuElFR-iLcSiuMD6GPg3991T4kAgTFdhnV8B7Gikdsi8tdomOXt4Ddvv79ObkbHFx-ef85NfFwmmoxoUALavGGSWorWtfc1dxYVoFtSBSXklXa-W48gLzYKRAjqptNYm6Qt1W8oD92O5dx-HfRGm0q5AcdR32NEzJgoImJzTKfCyVUHFdad1kqdpKXRxSxtDadQwrjBsL3M6s7dJuWduZteVgM-ts-_aSMN3Pf6-mV7hZcLwVUEbyFCja5AL1jnyI5Ebrh_BRwvsFrgt9cNg90obScphin3FbsElYbq_ne8_nBslzqTv5HxsVpTI</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Santiago, Jose A</creator><creator>Potashkin, Judith A</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20130301</creationdate><title>Shared dysregulated pathways lead to Parkinson's disease and diabetes</title><author>Santiago, Jose A ; Potashkin, Judith A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-215369c742ef88d80c6027f4182ee4d43c854c04d2ad43732a0a4ff5e286a5f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Biomarkers - blood</topic><topic>Blood Glucose - analysis</topic><topic>Chronic Disease</topic><topic>diabetes</topic><topic>Diabetes Mellitus - genetics</topic><topic>Diabetes Mellitus - physiopathology</topic><topic>Disease Progression</topic><topic>Endoplasmic Reticulum Stress</topic><topic>Genetic Predisposition to Disease</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Inflammation - genetics</topic><topic>Inflammation - physiopathology</topic><topic>insulin resistance</topic><topic>Insulin Resistance - genetics</topic><topic>Insulin-Like Growth Factor I - genetics</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Mitochondria - metabolism</topic><topic>neurodegeneration</topic><topic>Parkinson Disease - genetics</topic><topic>Parkinson Disease - physiopathology</topic><topic>Parkinson's disease</topic><topic>Pathology</topic><topic>Transcription Factors</topic><topic>Vitamin D - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santiago, Jose A</creatorcontrib><creatorcontrib>Potashkin, Judith A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Trends in molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santiago, Jose A</au><au>Potashkin, Judith A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Shared dysregulated pathways lead to Parkinson's disease and diabetes</atitle><jtitle>Trends in molecular medicine</jtitle><addtitle>Trends Mol Med</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>19</volume><issue>3</issue><spage>176</spage><epage>186</epage><pages>176-186</pages><issn>1471-4914</issn><eissn>1471-499X</eissn><abstract>Recent evidence indicates that Parkinson's disease and diabetes, both age-related chronic diseases, share remarkably similar dysregulated pathways. Exposure to environmental factors and genetic susceptibility play a role in the etiology and progression of both diseases. In light of recent findings, an intriguing hypothesis has emerged that suggests that mitochondrial dysfunction, endoplasmic reticulum stress, inflammation, and alterations in metabolism may lead to insulin resistance and, ultimately, to diabetes and/or neurodegeneration. In this article, we summarize the studies that have addressed the relationship between Parkinson's disease and diabetes and propose that disruptions in these shared molecular networks lead to both chronic diseases.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>23375873</pmid><doi>10.1016/j.molmed.2013.01.002</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1471-4914 |
| ispartof | Trends in molecular medicine, 2013-03, Vol.19 (3), p.176-186 |
| issn | 1471-4914 1471-499X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1419369947 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Biomarkers - blood Blood Glucose - analysis Chronic Disease diabetes Diabetes Mellitus - genetics Diabetes Mellitus - physiopathology Disease Progression Endoplasmic Reticulum Stress Genetic Predisposition to Disease Homeostasis Humans Inflammation - genetics Inflammation - physiopathology insulin resistance Insulin Resistance - genetics Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Mitochondria - metabolism neurodegeneration Parkinson Disease - genetics Parkinson Disease - physiopathology Parkinson's disease Pathology Transcription Factors Vitamin D - pharmacology |
| title | Shared dysregulated pathways lead to Parkinson's disease and diabetes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T20%3A56%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Shared%20dysregulated%20pathways%20lead%20to%20Parkinson's%20disease%20and%20diabetes&rft.jtitle=Trends%20in%20molecular%20medicine&rft.au=Santiago,%20Jose%20A&rft.date=2013-03-01&rft.volume=19&rft.issue=3&rft.spage=176&rft.epage=186&rft.pages=176-186&rft.issn=1471-4914&rft.eissn=1471-499X&rft_id=info:doi/10.1016/j.molmed.2013.01.002&rft_dat=%3Cproquest_cross%3E1419369947%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1316056559&rft_id=info:pmid/23375873&rft_els_id=S147149141300004X&rfr_iscdi=true |