Evaluation of the analgesic efficacy and psychoactive effects of AZD1940, a novel peripherally acting cannabinoid agonist, in human capsaicin-induced pain and hyperalgesia

Summary The aim of the present study was to investigate the effects of AZD1940, a novel peripherally acting cannabinoid CB1/CB2 receptor agonist, on capsaicin‐induced pain and hyperalgesia, as well as on biomarkers of cannabinoid central nervous system (CNS) effects. The present study was a randomiz...

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Veröffentlicht in:	CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 2013-03, Vol.40 (3), p.212-218
Hauptverfasser:	Kalliomäki, Jarkko, Annas, Peter, Huizar, Karin, Clarke, Cyril, Zettergren, Annika, Karlsten, Rolf, Segerdahl, Märta
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analgesics - administration & dosage Analgesics - adverse effects Analgesics - pharmacokinetics Analgesics - therapeutic use Benzimidazoles - administration & dosage Benzimidazoles - adverse effects Benzimidazoles - pharmacokinetics Benzimidazoles - therapeutic use cannabinoid Cannabinoid Receptor Agonists - administration & dosage Cannabinoid Receptor Agonists - adverse effects Cannabinoid Receptor Agonists - pharmacokinetics Cannabinoid Receptor Agonists - therapeutic use capsaicin Capsaicin - administration & dosage clinical trials Cross-Over Studies Double-Blind Method Female Humans Hyperalgesia - drug therapy Male Middle Aged pain Pain - drug therapy Pain Measurement Psychotropic Drugs - administration & dosage Psychotropic Drugs - adverse effects Psychotropic Drugs - pharmacokinetics Psychotropic Drugs - therapeutic use Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB2 - agonists Sulfonamides - administration & dosage Sulfonamides - adverse effects Sulfonamides - pharmacokinetics Sulfonamides - therapeutic use Treatment Outcome Young Adult
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