Constitutive autotaxin transcription by Nmyc-amplified and non-amplified neuroblastoma cells is regulated by a novel AP-1 and SP-mediated mechanism and abrogated by curcumin

► We report a novel transcriptional mechanism for autotaxin expression in human neuroblastoma cells. ► This mechanism is common to Nmyc amplified and non-amplified neuroblastoma cells. ► This mechanism involves functional CRE/AP-1-like and GA-box elements within the first 285bp of the autotaxin prom...

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Veröffentlicht in:	FEBS letters 2012-10, Vol.586 (20), p.3681-3691
Hauptverfasser:	Farina, Antonietta R., Cappabianca, Lucia, Ruggeri, Pierdomenico, Di Ianni, Natalia, Ragone, Marzia, Merolle, Stefania, Sano, Kimihiko, Stracke, Mary L., Horowitz, Jonathan M., Gulino, Alberto, Mackay, Andrew R.
Format:	Artikel
Sprache:	eng
Schlagworte:	activating transcription factor activator protein-1 AP-1 AP1 ATF Atx Autotaxin cAMP response element Cell Line, Tumor ChIp chromatin immunoprecipitation CRE CRE binding protein CREB Curcumin Curcumin - pharmacology Cyclic AMP - genetics electro-mobility shift assay EMSA GAPDH Gene Deletion Genes, Reporter - genetics glyceraldehyde-3-phosphate dehydrogenase Humans Internally initiated SP3 Neuroblastoma Neuroblastoma - pathology Phosphoric Diester Hydrolases - deficiency Phosphoric Diester Hydrolases - genetics Proto-Oncogene Proteins c-myc - metabolism Response Elements - drug effects Response Elements - genetics Sp Transcription Factors - metabolism specificity protein Transcription Transcription Factor AP-1 - metabolism Transcription, Genetic - drug effects Transcriptional Activation - drug effects
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