The Beneficial Effects of Early Short-Term Exercise in the Offspring of Obese Mothers are Accompanied by Alterations in the Hypothalamic Gene Expression of Appetite Regulators and FTO (Fat Mass and Obesity Associated) Gene
Maternal overnutrition is implicated in the development of adult metabolic disease, and has been shown to alter the expression of genes involved in energy homeostasis. In the present study, we aimed to test whether a short period of voluntary exercise, followed by a sedentary period, would regulate...
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| Veröffentlicht in: | Journal of neuroendocrinology 2013-08, Vol.25 (8), p.742-752 |
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| description | Maternal overnutrition is implicated in the development of adult metabolic disease, and has been shown to alter the expression of genes involved in energy homeostasis. In the present study, we aimed to test whether a short period of voluntary exercise, followed by a sedentary period, would regulate hypothalamic markers involved in appetite. Adult female Sprague–Dawley rats were fed either normal chow or high‐fat diet (HFD) ad lib. for 5 weeks, mated and continued on their assigned diet during gestation/lactation. At weaning males, were separated into chow or HFD groups; half were exercised (running wheels), whereas the remainder were sedentary. At week 10, wheels were removed and rats remained sedentary for 5 weeks, prior to tissue collection. Maternal obesity increased offspring adiposity at 15 weeks and this was exacerbated by postnatal HFD (P |
| doi_str_mv | 10.1111/jne.12053 |
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J.</creator><creatorcontrib>Caruso, V. ; Bahari, H. ; Morris, M. J.</creatorcontrib><description>Maternal overnutrition is implicated in the development of adult metabolic disease, and has been shown to alter the expression of genes involved in energy homeostasis. In the present study, we aimed to test whether a short period of voluntary exercise, followed by a sedentary period, would regulate hypothalamic markers involved in appetite. Adult female Sprague–Dawley rats were fed either normal chow or high‐fat diet (HFD) ad lib. for 5 weeks, mated and continued on their assigned diet during gestation/lactation. At weaning males, were separated into chow or HFD groups; half were exercised (running wheels), whereas the remainder were sedentary. At week 10, wheels were removed and rats remained sedentary for 5 weeks, prior to tissue collection. Maternal obesity increased offspring adiposity at 15 weeks and this was exacerbated by postnatal HFD (P < 0.05). Body weight and fat mass were reduced in offspring of obese mothers if they exercised, and this was maintained even after 5 weeks without exercise. At 15 weeks, fasting plasma insulin, leptin and triglyceride concentrations were significantly reduced by exercise in offspring of lean and obese mothers consuming chow, with little benefit in those consuming HFD. Hypothalamic mRNA expression of pro‐opiomelanocortin was increased by exercise but only in offspring of lean mothers. Exercise reduced hypothalamic FTO (fat mass and obesity associated) mRNA in offspring of lean dams regardless of diet. A short period of exercise early in life had lasting beneficial effects on body weight, adiposity and hormone profile of male offspring from obese and lean dams, despite being followed by a period of inactivity. The effects of exercise on hypothalamic appetite regulators were more marked in offspring of lean dams.</description><identifier>ISSN: 0953-8194</identifier><identifier>EISSN: 1365-2826</identifier><identifier>DOI: 10.1111/jne.12053</identifier><identifier>PMID: 23701669</identifier><language>eng</language><publisher>Oxford: Blackwell Publishing Ltd</publisher><subject>Adipose tissue ; Adiposity ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO ; Animals ; Biological and medical sciences ; Blood Glucose - metabolism ; Body Weight ; exercise ; fat mass and obesity associated gene ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation ; hypothalamus ; Hypothalamus - metabolism ; Maternal Exposure ; maternal obesity ; Medical sciences ; Metabolic diseases ; neuropeptide Y ; Obesity ; Obesity - metabolism ; Obesity - physiopathology ; Physical Conditioning, Animal ; pro-opiomelanocortin ; Proteins - genetics ; Rats ; Rats, Sprague-Dawley ; Vertebrates: endocrinology</subject><ispartof>Journal of neuroendocrinology, 2013-08, Vol.25 (8), p.742-752</ispartof><rights>2013 British Society for Neuroendocrinology</rights><rights>2014 INIST-CNRS</rights><rights>2013 British Society for Neuroendocrinology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4543-545590769785e11778a2ce444550b1ca6cb6f324009ed4a5c170b4c65401a24e3</citedby><cites>FETCH-LOGICAL-c4543-545590769785e11778a2ce444550b1ca6cb6f324009ed4a5c170b4c65401a24e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjne.12053$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjne.12053$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27540111$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23701669$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caruso, V.</creatorcontrib><creatorcontrib>Bahari, H.</creatorcontrib><creatorcontrib>Morris, M. J.</creatorcontrib><title>The Beneficial Effects of Early Short-Term Exercise in the Offspring of Obese Mothers are Accompanied by Alterations in the Hypothalamic Gene Expression of Appetite Regulators and FTO (Fat Mass and Obesity Associated) Gene</title><title>Journal of neuroendocrinology</title><addtitle>J Neuroendocrinol</addtitle><description>Maternal overnutrition is implicated in the development of adult metabolic disease, and has been shown to alter the expression of genes involved in energy homeostasis. In the present study, we aimed to test whether a short period of voluntary exercise, followed by a sedentary period, would regulate hypothalamic markers involved in appetite. Adult female Sprague–Dawley rats were fed either normal chow or high‐fat diet (HFD) ad lib. for 5 weeks, mated and continued on their assigned diet during gestation/lactation. At weaning males, were separated into chow or HFD groups; half were exercised (running wheels), whereas the remainder were sedentary. At week 10, wheels were removed and rats remained sedentary for 5 weeks, prior to tissue collection. Maternal obesity increased offspring adiposity at 15 weeks and this was exacerbated by postnatal HFD (P < 0.05). Body weight and fat mass were reduced in offspring of obese mothers if they exercised, and this was maintained even after 5 weeks without exercise. At 15 weeks, fasting plasma insulin, leptin and triglyceride concentrations were significantly reduced by exercise in offspring of lean and obese mothers consuming chow, with little benefit in those consuming HFD. Hypothalamic mRNA expression of pro‐opiomelanocortin was increased by exercise but only in offspring of lean mothers. Exercise reduced hypothalamic FTO (fat mass and obesity associated) mRNA in offspring of lean dams regardless of diet. A short period of exercise early in life had lasting beneficial effects on body weight, adiposity and hormone profile of male offspring from obese and lean dams, despite being followed by a period of inactivity. The effects of exercise on hypothalamic appetite regulators were more marked in offspring of lean dams.</description><subject>Adipose tissue</subject><subject>Adiposity</subject><subject>Alpha-Ketoglutarate-Dependent Dioxygenase FTO</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Body Weight</subject><subject>exercise</subject><subject>fat mass and obesity associated gene</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation</subject><subject>hypothalamus</subject><subject>Hypothalamus - metabolism</subject><subject>Maternal Exposure</subject><subject>maternal obesity</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>neuropeptide Y</subject><subject>Obesity</subject><subject>Obesity - metabolism</subject><subject>Obesity - physiopathology</subject><subject>Physical Conditioning, Animal</subject><subject>pro-opiomelanocortin</subject><subject>Proteins - genetics</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Vertebrates: endocrinology</subject><issn>0953-8194</issn><issn>1365-2826</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks9uEzEQxlcIREPhwAsgSwipPWxrr-317jGNNilVkyAI4mh5ndnWYf9hO6J5WZ4Fb5MUCQkJXyzN_Ob7ZjQTRW8JviDhXW5auCAJ5vRZNCI05XGSJenzaIRzTuOM5OwkeuXcBmMiOMUvo5OECkzSNB9Fv1b3gK6ghcpoo2pUVBVo71BXoULZeoe-3HfWxyuwDSoewGrjAJkW-VC2rCrXW9PeDfSyhJCZdyFhHVIW0FjrrulVa2CNyh0a1x6s8qZr3VHgetcHXtWqMRrNQhPBorfgXIAGzXHfgzce0Ge429bKd4Nyu0bT1RKdTZVHc-X2kcHd-GDiXBfm8LA-fxR8Hb2oVO3gzeE_jb5Oi9XkOr5dzj5OxrexZpzRmDPOcyzSXGQcCBEiU4kGxkIYl0SrVJdpRROGcQ5rprgmApdMp5xhohIG9DQ62-v2tvuxBedlY5yGulYtdFsnCSM5TXOekP9AcRo64BkN6Pu_0E23tW0YJFCJyBjNGQ7U-Z7StnPOQiXDUhpld5JgOdyHDPchH-8jsO8OituygfUTeTyIAHw4AMppVVdWtWHlfzgxjEyGKS733E9Tw-7fjvJmURyt432FcR4eniqU_S5TQQWX3xYz-elmlUwmi7nk9DePCt_c</recordid><startdate>201308</startdate><enddate>201308</enddate><creator>Caruso, V.</creator><creator>Bahari, H.</creator><creator>Morris, M. J.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>RC3</scope></search><sort><creationdate>201308</creationdate><title>The Beneficial Effects of Early Short-Term Exercise in the Offspring of Obese Mothers are Accompanied by Alterations in the Hypothalamic Gene Expression of Appetite Regulators and FTO (Fat Mass and Obesity Associated) Gene</title><author>Caruso, V. ; Bahari, H. ; Morris, M. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4543-545590769785e11778a2ce444550b1ca6cb6f324009ed4a5c170b4c65401a24e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adipose tissue</topic><topic>Adiposity</topic><topic>Alpha-Ketoglutarate-Dependent Dioxygenase FTO</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Body Weight</topic><topic>exercise</topic><topic>fat mass and obesity associated gene</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation</topic><topic>hypothalamus</topic><topic>Hypothalamus - metabolism</topic><topic>Maternal Exposure</topic><topic>maternal obesity</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>neuropeptide Y</topic><topic>Obesity</topic><topic>Obesity - metabolism</topic><topic>Obesity - physiopathology</topic><topic>Physical Conditioning, Animal</topic><topic>pro-opiomelanocortin</topic><topic>Proteins - genetics</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caruso, V.</creatorcontrib><creatorcontrib>Bahari, H.</creatorcontrib><creatorcontrib>Morris, M. 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J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Beneficial Effects of Early Short-Term Exercise in the Offspring of Obese Mothers are Accompanied by Alterations in the Hypothalamic Gene Expression of Appetite Regulators and FTO (Fat Mass and Obesity Associated) Gene</atitle><jtitle>Journal of neuroendocrinology</jtitle><addtitle>J Neuroendocrinol</addtitle><date>2013-08</date><risdate>2013</risdate><volume>25</volume><issue>8</issue><spage>742</spage><epage>752</epage><pages>742-752</pages><issn>0953-8194</issn><eissn>1365-2826</eissn><abstract>Maternal overnutrition is implicated in the development of adult metabolic disease, and has been shown to alter the expression of genes involved in energy homeostasis. In the present study, we aimed to test whether a short period of voluntary exercise, followed by a sedentary period, would regulate hypothalamic markers involved in appetite. Adult female Sprague–Dawley rats were fed either normal chow or high‐fat diet (HFD) ad lib. for 5 weeks, mated and continued on their assigned diet during gestation/lactation. At weaning males, were separated into chow or HFD groups; half were exercised (running wheels), whereas the remainder were sedentary. At week 10, wheels were removed and rats remained sedentary for 5 weeks, prior to tissue collection. Maternal obesity increased offspring adiposity at 15 weeks and this was exacerbated by postnatal HFD (P < 0.05). Body weight and fat mass were reduced in offspring of obese mothers if they exercised, and this was maintained even after 5 weeks without exercise. At 15 weeks, fasting plasma insulin, leptin and triglyceride concentrations were significantly reduced by exercise in offspring of lean and obese mothers consuming chow, with little benefit in those consuming HFD. Hypothalamic mRNA expression of pro‐opiomelanocortin was increased by exercise but only in offspring of lean mothers. Exercise reduced hypothalamic FTO (fat mass and obesity associated) mRNA in offspring of lean dams regardless of diet. A short period of exercise early in life had lasting beneficial effects on body weight, adiposity and hormone profile of male offspring from obese and lean dams, despite being followed by a period of inactivity. The effects of exercise on hypothalamic appetite regulators were more marked in offspring of lean dams.</abstract><cop>Oxford</cop><pub>Blackwell Publishing Ltd</pub><pmid>23701669</pmid><doi>10.1111/jne.12053</doi><tpages>11</tpages></addata></record> |
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| issn | 0953-8194 1365-2826 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adipose tissue Adiposity Alpha-Ketoglutarate-Dependent Dioxygenase FTO Animals Biological and medical sciences Blood Glucose - metabolism Body Weight exercise fat mass and obesity associated gene Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation hypothalamus Hypothalamus - metabolism Maternal Exposure maternal obesity Medical sciences Metabolic diseases neuropeptide Y Obesity Obesity - metabolism Obesity - physiopathology Physical Conditioning, Animal pro-opiomelanocortin Proteins - genetics Rats Rats, Sprague-Dawley Vertebrates: endocrinology |
| title | The Beneficial Effects of Early Short-Term Exercise in the Offspring of Obese Mothers are Accompanied by Alterations in the Hypothalamic Gene Expression of Appetite Regulators and FTO (Fat Mass and Obesity Associated) Gene |
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