Polymorphisms in histone deacetylases improve the predictive value of IL-28B for chronic hepatitis C therapy

Histone deacetylases (HDACs) influence many cellular processes, including the modulation of signal transducer and activator of transcription activity (STAT) in response to interferon (IFN). To identify genetic markers that help optimize the IL-28B prediction of chronic hepatitis C (CHC) sustained vi...

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Veröffentlicht in:	Genes and immunity 2013-07, Vol.14 (5), p.317-324
Hauptverfasser:	López-Rodríguez, R, Hernández-Bartolomé, Á, Borque, M J, Rodríguez-Muñoz, Y, Martín-Vílchez, S, Trapero-Marugán, M, García-Buey, L, Muñoz de Rueda, P, Rodrigo, L, Vidal-Castiñeira, J R, Salmerón, J, Moreno-Otero, R, Sanz-Cameno, P
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/248 631/208/721 631/250/255/234/2513/1551 631/326/596/2553 Adult Aged Alleles Antiviral Agents - therapeutic use Biomedical and Life Sciences Biomedicine Cancer Research Drug Therapy, Combination Female Gastroenterology Gene Expression Gene Frequency Genes Genetic aspects Genetic markers Genetic polymorphisms Genotype Genotype & phenotype Genotyping HDAC2 protein Hepacivirus - drug effects Hepacivirus - genetics Hepatitis C Hepatitis C virus Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - genetics Hepatitis C, Chronic - virology Histone deacetylase Histone Deacetylases - genetics Histones Human Genetics Humans Immune response Immunology Interferon Interferon-alpha - chemistry Interferon-alpha - therapeutic use Interferons Interleukins Interleukins - genetics Isoenzymes - genetics Liver cancer Logistic Models Male Middle Aged Multivariate Analysis original-article Patient outcomes Physiological aspects Polyethylene Glycols - chemistry Polymorphism, Single Nucleotide Prediction models Prognosis Ribavirin - therapeutic use Single-nucleotide polymorphism Transcription Treatment Outcome Viral Load - drug effects Viral Load - genetics Young Adult
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Zusammenfassung:	Histone deacetylases (HDACs) influence many cellular processes, including the modulation of signal transducer and activator of transcription activity (STAT) in response to interferon (IFN). To identify genetic markers that help optimize the IL-28B prediction of chronic hepatitis C (CHC) sustained virological response (SVR), we evaluated 27 single-nucleotide polymorphisms (SNPs) in HDAC1–11 . Three SNPs, rs3778216, rs976552 and rs368328 in HDAC2 , HDAC3 and HDAC5 , respectively, were independently associated with SVR ( P
ISSN:	1466-4879 1476-5470
DOI:	10.1038/gene.2013.24