Role of physiological factors in predicting the risk of oncological diseases on the basis of the polymorphism of the xenobiotic metabolism enzyme system
Summarized recent data on the polymorphism of the xenobiotic metabolism and detoxification enzyme (XMDE) system in humans are presented. The current notions on the molecular mechanisms of metabolic processes and the role of genetic polymorphism are reviewed. The roles of transport proteins and nucle...
Gespeichert in:
| Veröffentlicht in: | Human physiology 2010, Vol.36 (6), p.723-736 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 736 |
|---|---|
| container_issue | 6 |
| container_start_page | 723 |
| container_title | Human physiology |
| container_volume | 36 |
| creator | Sukhanov, V. A Piruzyan, L. A |
| description | Summarized recent data on the polymorphism of the xenobiotic metabolism and detoxification enzyme (XMDE) system in humans are presented. The current notions on the molecular mechanisms of metabolic processes and the role of genetic polymorphism are reviewed. The roles of transport proteins and nuclear receptors in the regulation of the activity of the XMDE system are shown. The possibilities of using the polymorphism of the XMDE system as the basis for predicting the risk of oncological diseases are considered. Experimental modeling of different levels of the epoxide synthetase and epoxide hydratase activities revealed their close relationship with the toxic, mutagenic, and carcinogenic actions of polycyclic aromatic hydrocarbons. The data indicating the necessity of considering the physiological factors that could influence xenobiotic metabolism and the development of pathological changes are given. |
| doi_str_mv | 10.1134/S0362119710060149 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1419364247</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1419364247</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2609-8e5e0484a3268e07d33582bbaf5f8712ea7f20efca9d83de20b2c7fcdf66452f3</originalsourceid><addsrcrecordid>eNp9kc9u1DAQxq0KJJbCA3Cqj1zSjv-skxxRBS1SpUqUni3HGe-6JHHqyUqkT8LjkrCFC1JPo5nv94008zH2QcC5EEpf3IEyUoi6FAAGhK5P2EYYqAoljH7FNqtcrPob9pboAQBKUdUb9utb6pCnwMf9TDF1aRe963hwfkqZeBz4mLGNforDjk975DnSj5VPg_9Ht5HQEdIy_MM0jiKt0NqMqZv7lMd9pP7v7CcOqYlpip73OLkmdauIw9PcI6eZJuzfsdfBdYTvn-spu__y-fvldXFze_X18tNN4aWBuqhwi6Ar7ZQ0FULZKrWtZNO4sA1VKSS6MkjA4F3dVqpFCY30ZfBtMEZvZVCn7ONx75jT4wFpsn0kj13nBkwHskKLWhktdbmg4oj6nIgyBjvm2Ls8WwF2TcH-l8LikUcPLeyww2wf0iEPy0Uvms6OpuCSdbvl5fb-ToJQIOqlaK1-A7PWlhA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1419364247</pqid></control><display><type>article</type><title>Role of physiological factors in predicting the risk of oncological diseases on the basis of the polymorphism of the xenobiotic metabolism enzyme system</title><source>Springer Nature - Complete Springer Journals</source><creator>Sukhanov, V. A ; Piruzyan, L. A</creator><creatorcontrib>Sukhanov, V. A ; Piruzyan, L. A</creatorcontrib><description>Summarized recent data on the polymorphism of the xenobiotic metabolism and detoxification enzyme (XMDE) system in humans are presented. The current notions on the molecular mechanisms of metabolic processes and the role of genetic polymorphism are reviewed. The roles of transport proteins and nuclear receptors in the regulation of the activity of the XMDE system are shown. The possibilities of using the polymorphism of the XMDE system as the basis for predicting the risk of oncological diseases are considered. Experimental modeling of different levels of the epoxide synthetase and epoxide hydratase activities revealed their close relationship with the toxic, mutagenic, and carcinogenic actions of polycyclic aromatic hydrocarbons. The data indicating the necessity of considering the physiological factors that could influence xenobiotic metabolism and the development of pathological changes are given.</description><identifier>ISSN: 0362-1197</identifier><identifier>EISSN: 1608-3164</identifier><identifier>DOI: 10.1134/S0362119710060149</identifier><language>eng</language><publisher>Dordrecht: Dordrecht : SP MAIK Nauka/Interperiodica</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; epoxide hydratase ; epoxide synthetase ; Human Physiology ; Life Sciences ; physiological factors ; polymorphism ; Reviews ; xenobiotic metabolism and detoxification enzyme system</subject><ispartof>Human physiology, 2010, Vol.36 (6), p.723-736</ispartof><rights>Pleiades Publishing, Ltd. 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2609-8e5e0484a3268e07d33582bbaf5f8712ea7f20efca9d83de20b2c7fcdf66452f3</citedby><cites>FETCH-LOGICAL-c2609-8e5e0484a3268e07d33582bbaf5f8712ea7f20efca9d83de20b2c7fcdf66452f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S0362119710060149$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S0362119710060149$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids></links><search><creatorcontrib>Sukhanov, V. A</creatorcontrib><creatorcontrib>Piruzyan, L. A</creatorcontrib><title>Role of physiological factors in predicting the risk of oncological diseases on the basis of the polymorphism of the xenobiotic metabolism enzyme system</title><title>Human physiology</title><addtitle>Hum Physiol</addtitle><description>Summarized recent data on the polymorphism of the xenobiotic metabolism and detoxification enzyme (XMDE) system in humans are presented. The current notions on the molecular mechanisms of metabolic processes and the role of genetic polymorphism are reviewed. The roles of transport proteins and nuclear receptors in the regulation of the activity of the XMDE system are shown. The possibilities of using the polymorphism of the XMDE system as the basis for predicting the risk of oncological diseases are considered. Experimental modeling of different levels of the epoxide synthetase and epoxide hydratase activities revealed their close relationship with the toxic, mutagenic, and carcinogenic actions of polycyclic aromatic hydrocarbons. The data indicating the necessity of considering the physiological factors that could influence xenobiotic metabolism and the development of pathological changes are given.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>epoxide hydratase</subject><subject>epoxide synthetase</subject><subject>Human Physiology</subject><subject>Life Sciences</subject><subject>physiological factors</subject><subject>polymorphism</subject><subject>Reviews</subject><subject>xenobiotic metabolism and detoxification enzyme system</subject><issn>0362-1197</issn><issn>1608-3164</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp9kc9u1DAQxq0KJJbCA3Cqj1zSjv-skxxRBS1SpUqUni3HGe-6JHHqyUqkT8LjkrCFC1JPo5nv94008zH2QcC5EEpf3IEyUoi6FAAGhK5P2EYYqAoljH7FNqtcrPob9pboAQBKUdUb9utb6pCnwMf9TDF1aRe963hwfkqZeBz4mLGNforDjk975DnSj5VPg_9Ht5HQEdIy_MM0jiKt0NqMqZv7lMd9pP7v7CcOqYlpip73OLkmdauIw9PcI6eZJuzfsdfBdYTvn-spu__y-fvldXFze_X18tNN4aWBuqhwi6Ar7ZQ0FULZKrWtZNO4sA1VKSS6MkjA4F3dVqpFCY30ZfBtMEZvZVCn7ONx75jT4wFpsn0kj13nBkwHskKLWhktdbmg4oj6nIgyBjvm2Ls8WwF2TcH-l8LikUcPLeyww2wf0iEPy0Uvms6OpuCSdbvl5fb-ToJQIOqlaK1-A7PWlhA</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Sukhanov, V. A</creator><creator>Piruzyan, L. A</creator><general>Dordrecht : SP MAIK Nauka/Interperiodica</general><general>SP MAIK Nauka/Interperiodica</general><scope>FBQ</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>2010</creationdate><title>Role of physiological factors in predicting the risk of oncological diseases on the basis of the polymorphism of the xenobiotic metabolism enzyme system</title><author>Sukhanov, V. A ; Piruzyan, L. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2609-8e5e0484a3268e07d33582bbaf5f8712ea7f20efca9d83de20b2c7fcdf66452f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>epoxide hydratase</topic><topic>epoxide synthetase</topic><topic>Human Physiology</topic><topic>Life Sciences</topic><topic>physiological factors</topic><topic>polymorphism</topic><topic>Reviews</topic><topic>xenobiotic metabolism and detoxification enzyme system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sukhanov, V. A</creatorcontrib><creatorcontrib>Piruzyan, L. A</creatorcontrib><collection>AGRIS</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Human physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sukhanov, V. A</au><au>Piruzyan, L. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of physiological factors in predicting the risk of oncological diseases on the basis of the polymorphism of the xenobiotic metabolism enzyme system</atitle><jtitle>Human physiology</jtitle><stitle>Hum Physiol</stitle><date>2010</date><risdate>2010</risdate><volume>36</volume><issue>6</issue><spage>723</spage><epage>736</epage><pages>723-736</pages><issn>0362-1197</issn><eissn>1608-3164</eissn><abstract>Summarized recent data on the polymorphism of the xenobiotic metabolism and detoxification enzyme (XMDE) system in humans are presented. The current notions on the molecular mechanisms of metabolic processes and the role of genetic polymorphism are reviewed. The roles of transport proteins and nuclear receptors in the regulation of the activity of the XMDE system are shown. The possibilities of using the polymorphism of the XMDE system as the basis for predicting the risk of oncological diseases are considered. Experimental modeling of different levels of the epoxide synthetase and epoxide hydratase activities revealed their close relationship with the toxic, mutagenic, and carcinogenic actions of polycyclic aromatic hydrocarbons. The data indicating the necessity of considering the physiological factors that could influence xenobiotic metabolism and the development of pathological changes are given.</abstract><cop>Dordrecht</cop><pub>Dordrecht : SP MAIK Nauka/Interperiodica</pub><doi>10.1134/S0362119710060149</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0362-1197 |
| ispartof | Human physiology, 2010, Vol.36 (6), p.723-736 |
| issn | 0362-1197 1608-3164 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1419364247 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Biomedical and Life Sciences Biomedicine epoxide hydratase epoxide synthetase Human Physiology Life Sciences physiological factors polymorphism Reviews xenobiotic metabolism and detoxification enzyme system |
| title | Role of physiological factors in predicting the risk of oncological diseases on the basis of the polymorphism of the xenobiotic metabolism enzyme system |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T11%3A05%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20physiological%20factors%20in%20predicting%20the%20risk%20of%20oncological%20diseases%20on%20the%20basis%20of%20the%20polymorphism%20of%20the%20xenobiotic%20metabolism%20enzyme%20system&rft.jtitle=Human%20physiology&rft.au=Sukhanov,%20V.%20A&rft.date=2010&rft.volume=36&rft.issue=6&rft.spage=723&rft.epage=736&rft.pages=723-736&rft.issn=0362-1197&rft.eissn=1608-3164&rft_id=info:doi/10.1134/S0362119710060149&rft_dat=%3Cproquest_cross%3E1419364247%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1419364247&rft_id=info:pmid/&rfr_iscdi=true |