Electrophysiological characterization of sodium-activated potassium channels in NG108-15 and NSC-34 motor neuron-like cells

Aims The electrical properties of Na+‐activated K+ current (IK(Na)) and its contribution to spike firing has not been characterized in motor neurons. Methods We evaluated how activation of voltage‐gated K+ current (IK) at the cellular level could be coupled to Na+ influx through voltage‐gated Na+ cu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Acta Physiologica 2012-10, Vol.206 (2), p.120-134
Hauptverfasser:	Wu, S.-N., Yeh, C.-C., Huang, H.-C., So, E. C., Lo, Y.-C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetanilides - pharmacology Action Potentials Animals Biological and medical sciences Cell Line, Tumor Cyclopropanes - pharmacology Electric Stimulation Fundamental and applied biological sciences. Psychology Hydrocarbons, Fluorinated - pharmacology Ion Channel Gating - drug effects K+ current Kinetics Mice Models, Neurological motor neurons Motor Neurons - metabolism Na+ current Na+-activated K+ channels Patch-Clamp Techniques Piperazines - pharmacology Potassium - metabolism Potassium Channels, Voltage-Gated - drug effects Potassium Channels, Voltage-Gated - metabolism pyrethroid Ranolazine Rats Riluzole - pharmacology simulation Sodium - metabolism Sodium Channel Blockers - pharmacology Tetrodotoxin - pharmacology Vertebrates: anatomy and physiology, studies on body, several organs or systems Voltage-Gated Sodium Channels - drug effects Voltage-Gated Sodium Channels - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!