Differential autophagic cell death under stress with ectopic cytoplasmic and mitochondrial-specific PPP2R2B in human neuroblastoma cells

Protein phosphatase 2A is one of four major classes of serine/threonine phosphatases. Overexpression of brain-specific regulatory subunit PPP2R2 in neuron cells is implicated in pathogenesis. The alternative splicing of PPP2R2B encodes two isoforms. They are subunit of cytoplasmic specific Bβ1 and m...

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Veröffentlicht in:	Apoptosis (London) 2013-05, Vol.18 (5), p.627-638
Hauptverfasser:	Fang, Kang, Li, Hui-Fang, Hsieh, Chang-Heng, Li, Dan-Yu, Song, Ding-Chieh, Cheng, Wan-Ting, Guo, Zhi-Xuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - pharmacology Autophagy - genetics Biochemistry Biomedical and Life Sciences Biomedicine Cancer Research Cell Biology Cell death Cell Line, Tumor Clone Cells Cytosol - drug effects Cytosol - enzymology Endoplasmic Reticulum Stress - genetics Environmental stress Fluorescence microscopy Gene Expression Regulation Humans Isoenzymes - genetics Isoenzymes - metabolism Macrolides - pharmacology Membrane Potential, Mitochondrial - drug effects Mitochondria - drug effects Mitochondria - enzymology Mitochondria - genetics Mortality Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons - cytology Neurons - drug effects Neurons - enzymology Oncology Original Paper Protein Phosphatase 2 - genetics Protein Phosphatase 2 - metabolism Reactive Oxygen Species - metabolism Signal Transduction Stress, Physiological - genetics Transfection Tunicamycin - pharmacology Virology
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