Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis

Multiwalled carbon nanotubes (MWCNTs) have the potential for widespread applications in engineering and materials science. However, because of their needle-like shape and high durability, concerns have been raised that MWCNTs may induce asbestos-like pathogenicity. Although recent studies have demon...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-12, Vol.108 (49), p.E1330-E1338
Hauptverfasser:	Nagai, Hirotaka, Okazaki, Yasumasa, Chew, Shan Hwu, Misawa, Nobuaki, Yamashita, Yoriko, Akatsuka, Shinya, Ishihara, Toshikazu, Yamashita, Kyoko, Yoshikawa, Yutaka, Yasui, Hiroyuki, Jiang, Li, Ohara, Hiroki, Takahashi, Takashi, Ichihara, Gaku, Kostarelos, Kostas, Miyata, Yasumitsu, Shinohara, Hisanori, Toyokuni, Shinya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Asbestos Biological Sciences carbon nanotubes Carcinogenesis Carcinogenicity Carcinogens Cell Line cell membranes Cells Cells, Cultured Comparative Genomic Hybridization crystal structure Cyclin-Dependent Kinase Inhibitor p15 - genetics Cyclin-Dependent Kinase Inhibitor p16 - genetics Cytokines - genetics Cytotoxicity durability engineering Epithelial Cells - metabolism Epithelial Cells - ultrastructure Epithelium - injuries Epithelium - ultrastructure Gene Deletion Gene Expression Health hazards human health Humans macrophages Macrophages - metabolism Membranes Mesothelioma - etiology Mesothelioma - genetics Mesothelioma - metabolism Microscopy, Electron, Scanning Microscopy, Electron, Transmission Mutation Nanotechnology Nanotubes Nanotubes, Carbon - poisoning Nanotubes, Carbon - ultrastructure pathogenicity Pathogens PNAS Plus Rats Reverse Transcriptase Polymerase Chain Reaction Rigidity tumor suppressor genes
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