Food restriction, ghrelin, its antagonist and obestatin control expression of ghrelin and its receptor in chicken hypothalamus and ovary
The purpose of the present study was to identify the role of age, nutritional state and some metabolic hormones in control of avian hypothalamic and ovarian ghrelin/ghrelin receptor system. We examined the effect of food restriction, administration of ghrelin 1–18, ghrelin antagonistic analogue (D-L...
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| creator | Sirotkin, Alexander V. Pavlova, Silvia Tena-Sempere, Manuel Grossmann, Roland Jiménez, Magdalena Romero Rodriguez, Juan Manuel Castellano Valenzuela, Francisco |
| description | The purpose of the present study was to identify the role of age, nutritional state and some metabolic hormones in control of avian hypothalamic and ovarian ghrelin/ghrelin receptor system. We examined the effect of food restriction, administration of ghrelin 1–18, ghrelin antagonistic analogue (D-Lys-3)-GHRP-6, obestatin and combinations of them on the expression of ghrelin and ghrelin receptor (GHS-R1a) in hypothalamus and ovary of old (23months of age) and young (7months of age) chickens. Expression of mRNAs for ghrelin and GHS-R1a in both hypothalamus and largest ovarian follicle was measured by RT-PCR. It was observed that food restriction could promote the expression of ghrelin and GHS-R1a in hypothalamus and ovary of the old chickens, but in the young chickens it reduced expression of ghrelin and did not affect expression of GHS-R1a in the ovary. Administration of ghrelin 1–18 did not affect hypothalamic or ovarian ghrelin mRNA, but significantly increased the expression of GHS-R1a in hypothalamus, but not in ovary. (D-Lys-3)-GHRP-6, significantly stimulated accumulation of ghrelin, but not GHS-R1a mRNA in hypothalamus or ghrelin or GHS-R1a in the ovary. Ghrelin 1–18 and (D-Lys-3)-GHRP-6, when given together, were able either to prevent or to induce effect of these hormones. Obestatin administration increased expression of ghrelin gene in the hypothalamus, but not expression of hypothalamic GHS-R1a, ovarian ghrelin and GHS-R1a. Furthermore, obestatin was able to modify effect of both ghrelin and fasting on hypothalamic and ovarian mRNA for ghrelin GHS-R1a. Our results (1) confirm the existence of ghrelin and its functional receptors GHS-R1a in the chicken hypothalamus and ovary (2) confirm the age-dependent control of ovarian ghrelin by feeding, (3) demonstrate, that nutritional status can influence the expression of both ghrelin and GHS-R1a in hypothalamus and in the ovary (3) demonstrates for the first time, that ghrelin can promote generation of its functional receptor in the hypothalamus, but not in the ovary, (4) show that ghrelin1–18 and (D-Lys-3)-GHRP-6 could not only be antagonists in the action on chicken hypothalamus and ovaries, but also independent regulators and even agonists, and (5) provide first evidence for action of obestatin on hypothalamic ghrelin and on the response of hypothalamic and ovarian ghrelin/GHS-R1a system to food restriction. These data indicate the involvement of both hypothalamic and ovarian ghrelin/GHS-R1 systems i |
| doi_str_mv | 10.1016/j.cbpa.2012.07.010 |
| format | Article |
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We examined the effect of food restriction, administration of ghrelin 1–18, ghrelin antagonistic analogue (D-Lys-3)-GHRP-6, obestatin and combinations of them on the expression of ghrelin and ghrelin receptor (GHS-R1a) in hypothalamus and ovary of old (23months of age) and young (7months of age) chickens. Expression of mRNAs for ghrelin and GHS-R1a in both hypothalamus and largest ovarian follicle was measured by RT-PCR. It was observed that food restriction could promote the expression of ghrelin and GHS-R1a in hypothalamus and ovary of the old chickens, but in the young chickens it reduced expression of ghrelin and did not affect expression of GHS-R1a in the ovary. Administration of ghrelin 1–18 did not affect hypothalamic or ovarian ghrelin mRNA, but significantly increased the expression of GHS-R1a in hypothalamus, but not in ovary. (D-Lys-3)-GHRP-6, significantly stimulated accumulation of ghrelin, but not GHS-R1a mRNA in hypothalamus or ghrelin or GHS-R1a in the ovary. Ghrelin 1–18 and (D-Lys-3)-GHRP-6, when given together, were able either to prevent or to induce effect of these hormones. Obestatin administration increased expression of ghrelin gene in the hypothalamus, but not expression of hypothalamic GHS-R1a, ovarian ghrelin and GHS-R1a. Furthermore, obestatin was able to modify effect of both ghrelin and fasting on hypothalamic and ovarian mRNA for ghrelin GHS-R1a. Our results (1) confirm the existence of ghrelin and its functional receptors GHS-R1a in the chicken hypothalamus and ovary (2) confirm the age-dependent control of ovarian ghrelin by feeding, (3) demonstrate, that nutritional status can influence the expression of both ghrelin and GHS-R1a in hypothalamus and in the ovary (3) demonstrates for the first time, that ghrelin can promote generation of its functional receptor in the hypothalamus, but not in the ovary, (4) show that ghrelin1–18 and (D-Lys-3)-GHRP-6 could not only be antagonists in the action on chicken hypothalamus and ovaries, but also independent regulators and even agonists, and (5) provide first evidence for action of obestatin on hypothalamic ghrelin and on the response of hypothalamic and ovarian ghrelin/GHS-R1a system to food restriction. These data indicate the involvement of both hypothalamic and ovarian ghrelin/GHS-R1 systems in mediating the effects of nutritional status, ghrelin and obestatin on reproductive processes.</description><identifier>ISSN: 1095-6433</identifier><identifier>EISSN: 1531-4332</identifier><identifier>DOI: 10.1016/j.cbpa.2012.07.010</identifier><identifier>PMID: 22877785</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Age Factors ; agonists ; Animals ; antagonists ; Chicken ; chickens ; Chickens - genetics ; Chickens - metabolism ; fasting ; Feeding ; Female ; Food Deprivation ; Gene Expression Regulation, Developmental ; genes ; Ghrelin ; Ghrelin - antagonists & inhibitors ; Ghrelin - metabolism ; Ghrelin - pharmacology ; Ghrelin receptor (GHS-R1a) ; ghrelin receptors ; Humans ; Hypothalamus ; Hypothalamus - cytology ; Hypothalamus - drug effects ; Hypothalamus - metabolism ; messenger RNA ; nutritional status ; Obestatin ; Oligopeptides - pharmacology ; ovarian follicles ; Ovary ; Ovary - cytology ; Ovary - metabolism ; Receptors, Ghrelin - genetics ; Receptors, Ghrelin - metabolism ; Recombinant Proteins - pharmacology ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - genetics ; RNA, Messenger - metabolism</subject><ispartof>Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2013-01, Vol.164 (1), p.141-153</ispartof><rights>2012 Elsevier Inc.</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-718a334b52927071d9b5907146973f700961e805de34ab44c2e329f4d1c6cb513</citedby><cites>FETCH-LOGICAL-c479t-718a334b52927071d9b5907146973f700961e805de34ab44c2e329f4d1c6cb513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cbpa.2012.07.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,4026,27930,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22877785$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sirotkin, Alexander V.</creatorcontrib><creatorcontrib>Pavlova, Silvia</creatorcontrib><creatorcontrib>Tena-Sempere, Manuel</creatorcontrib><creatorcontrib>Grossmann, Roland</creatorcontrib><creatorcontrib>Jiménez, Magdalena Romero</creatorcontrib><creatorcontrib>Rodriguez, Juan Manuel Castellano</creatorcontrib><creatorcontrib>Valenzuela, Francisco</creatorcontrib><title>Food restriction, ghrelin, its antagonist and obestatin control expression of ghrelin and its receptor in chicken hypothalamus and ovary</title><title>Comparative biochemistry and physiology. Part A, Molecular & integrative physiology</title><addtitle>Comp Biochem Physiol A Mol Integr Physiol</addtitle><description>The purpose of the present study was to identify the role of age, nutritional state and some metabolic hormones in control of avian hypothalamic and ovarian ghrelin/ghrelin receptor system. We examined the effect of food restriction, administration of ghrelin 1–18, ghrelin antagonistic analogue (D-Lys-3)-GHRP-6, obestatin and combinations of them on the expression of ghrelin and ghrelin receptor (GHS-R1a) in hypothalamus and ovary of old (23months of age) and young (7months of age) chickens. Expression of mRNAs for ghrelin and GHS-R1a in both hypothalamus and largest ovarian follicle was measured by RT-PCR. It was observed that food restriction could promote the expression of ghrelin and GHS-R1a in hypothalamus and ovary of the old chickens, but in the young chickens it reduced expression of ghrelin and did not affect expression of GHS-R1a in the ovary. Administration of ghrelin 1–18 did not affect hypothalamic or ovarian ghrelin mRNA, but significantly increased the expression of GHS-R1a in hypothalamus, but not in ovary. (D-Lys-3)-GHRP-6, significantly stimulated accumulation of ghrelin, but not GHS-R1a mRNA in hypothalamus or ghrelin or GHS-R1a in the ovary. Ghrelin 1–18 and (D-Lys-3)-GHRP-6, when given together, were able either to prevent or to induce effect of these hormones. Obestatin administration increased expression of ghrelin gene in the hypothalamus, but not expression of hypothalamic GHS-R1a, ovarian ghrelin and GHS-R1a. Furthermore, obestatin was able to modify effect of both ghrelin and fasting on hypothalamic and ovarian mRNA for ghrelin GHS-R1a. Our results (1) confirm the existence of ghrelin and its functional receptors GHS-R1a in the chicken hypothalamus and ovary (2) confirm the age-dependent control of ovarian ghrelin by feeding, (3) demonstrate, that nutritional status can influence the expression of both ghrelin and GHS-R1a in hypothalamus and in the ovary (3) demonstrates for the first time, that ghrelin can promote generation of its functional receptor in the hypothalamus, but not in the ovary, (4) show that ghrelin1–18 and (D-Lys-3)-GHRP-6 could not only be antagonists in the action on chicken hypothalamus and ovaries, but also independent regulators and even agonists, and (5) provide first evidence for action of obestatin on hypothalamic ghrelin and on the response of hypothalamic and ovarian ghrelin/GHS-R1a system to food restriction. These data indicate the involvement of both hypothalamic and ovarian ghrelin/GHS-R1 systems in mediating the effects of nutritional status, ghrelin and obestatin on reproductive processes.</description><subject>Age Factors</subject><subject>agonists</subject><subject>Animals</subject><subject>antagonists</subject><subject>Chicken</subject><subject>chickens</subject><subject>Chickens - genetics</subject><subject>Chickens - metabolism</subject><subject>fasting</subject><subject>Feeding</subject><subject>Female</subject><subject>Food Deprivation</subject><subject>Gene Expression Regulation, Developmental</subject><subject>genes</subject><subject>Ghrelin</subject><subject>Ghrelin - antagonists & inhibitors</subject><subject>Ghrelin - metabolism</subject><subject>Ghrelin - pharmacology</subject><subject>Ghrelin receptor (GHS-R1a)</subject><subject>ghrelin receptors</subject><subject>Humans</subject><subject>Hypothalamus</subject><subject>Hypothalamus - cytology</subject><subject>Hypothalamus - drug effects</subject><subject>Hypothalamus - metabolism</subject><subject>messenger RNA</subject><subject>nutritional status</subject><subject>Obestatin</subject><subject>Oligopeptides - pharmacology</subject><subject>ovarian follicles</subject><subject>Ovary</subject><subject>Ovary - cytology</subject><subject>Ovary - metabolism</subject><subject>Receptors, Ghrelin - genetics</subject><subject>Receptors, Ghrelin - metabolism</subject><subject>Recombinant Proteins - pharmacology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><issn>1095-6433</issn><issn>1531-4332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1TAQhS0Eoj_wAiwgSxZN8G98LbGpKgpIlVhA15bjTO71JTcOtm9F34DHZkJaluDNjKXvHM3MIeQVow2jrH23b3w3u4ZTxhuqG8roE3LKlGC1FII_xZ4aVbf4OSFnOe8pPsnkc3LC-UZrvVGn5Nd1jH2VIJcUfAlxuqi2uwRjwCaUXLmpuG2cQi7Y9lXskHQlTJWPU0lxrODnjOqMyioOj9o_7CJP4GEuMVWLYhf8d5iq3f0cy86N7nDMq-mdS_cvyLPBjRlePtRzcnv94dvVp_rmy8fPV5c3tZfalFqzjRNCdoobrqlmvemUwSpbo8WgKTUtgw1VPQjpOik9B8HNIHvmW98pJs7J29V3TvHHEbexh5A9jKObIB6zZZIZoQwT7f9RzqlopaYKUb6iPsWcEwx2TuGAa1lG7RKW3dslLLuEZam2GBaKXj_4H7sD9H8lj-kg8GYFBhet26aQ7e1XdFCUIoO2SLxfCcCT3QVINvsAk4c-4OmL7WP41wS_AaIwr2w</recordid><startdate>201301</startdate><enddate>201301</enddate><creator>Sirotkin, Alexander V.</creator><creator>Pavlova, Silvia</creator><creator>Tena-Sempere, Manuel</creator><creator>Grossmann, Roland</creator><creator>Jiménez, Magdalena Romero</creator><creator>Rodriguez, Juan Manuel Castellano</creator><creator>Valenzuela, Francisco</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>201301</creationdate><title>Food restriction, ghrelin, its antagonist and obestatin control expression of ghrelin and its receptor in chicken hypothalamus and ovary</title><author>Sirotkin, Alexander V. ; Pavlova, Silvia ; Tena-Sempere, Manuel ; Grossmann, Roland ; Jiménez, Magdalena Romero ; Rodriguez, Juan Manuel Castellano ; Valenzuela, Francisco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-718a334b52927071d9b5907146973f700961e805de34ab44c2e329f4d1c6cb513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Age Factors</topic><topic>agonists</topic><topic>Animals</topic><topic>antagonists</topic><topic>Chicken</topic><topic>chickens</topic><topic>Chickens - genetics</topic><topic>Chickens - metabolism</topic><topic>fasting</topic><topic>Feeding</topic><topic>Female</topic><topic>Food Deprivation</topic><topic>Gene Expression Regulation, Developmental</topic><topic>genes</topic><topic>Ghrelin</topic><topic>Ghrelin - antagonists & inhibitors</topic><topic>Ghrelin - metabolism</topic><topic>Ghrelin - pharmacology</topic><topic>Ghrelin receptor (GHS-R1a)</topic><topic>ghrelin receptors</topic><topic>Humans</topic><topic>Hypothalamus</topic><topic>Hypothalamus - cytology</topic><topic>Hypothalamus - drug effects</topic><topic>Hypothalamus - metabolism</topic><topic>messenger RNA</topic><topic>nutritional status</topic><topic>Obestatin</topic><topic>Oligopeptides - pharmacology</topic><topic>ovarian follicles</topic><topic>Ovary</topic><topic>Ovary - cytology</topic><topic>Ovary - metabolism</topic><topic>Receptors, Ghrelin - genetics</topic><topic>Receptors, Ghrelin - metabolism</topic><topic>Recombinant Proteins - pharmacology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sirotkin, Alexander V.</creatorcontrib><creatorcontrib>Pavlova, Silvia</creatorcontrib><creatorcontrib>Tena-Sempere, Manuel</creatorcontrib><creatorcontrib>Grossmann, Roland</creatorcontrib><creatorcontrib>Jiménez, Magdalena Romero</creatorcontrib><creatorcontrib>Rodriguez, Juan Manuel Castellano</creatorcontrib><creatorcontrib>Valenzuela, Francisco</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Comparative biochemistry and physiology. Part A, Molecular & integrative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sirotkin, Alexander V.</au><au>Pavlova, Silvia</au><au>Tena-Sempere, Manuel</au><au>Grossmann, Roland</au><au>Jiménez, Magdalena Romero</au><au>Rodriguez, Juan Manuel Castellano</au><au>Valenzuela, Francisco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Food restriction, ghrelin, its antagonist and obestatin control expression of ghrelin and its receptor in chicken hypothalamus and ovary</atitle><jtitle>Comparative biochemistry and physiology. Part A, Molecular & integrative physiology</jtitle><addtitle>Comp Biochem Physiol A Mol Integr Physiol</addtitle><date>2013-01</date><risdate>2013</risdate><volume>164</volume><issue>1</issue><spage>141</spage><epage>153</epage><pages>141-153</pages><issn>1095-6433</issn><eissn>1531-4332</eissn><abstract>The purpose of the present study was to identify the role of age, nutritional state and some metabolic hormones in control of avian hypothalamic and ovarian ghrelin/ghrelin receptor system. We examined the effect of food restriction, administration of ghrelin 1–18, ghrelin antagonistic analogue (D-Lys-3)-GHRP-6, obestatin and combinations of them on the expression of ghrelin and ghrelin receptor (GHS-R1a) in hypothalamus and ovary of old (23months of age) and young (7months of age) chickens. Expression of mRNAs for ghrelin and GHS-R1a in both hypothalamus and largest ovarian follicle was measured by RT-PCR. It was observed that food restriction could promote the expression of ghrelin and GHS-R1a in hypothalamus and ovary of the old chickens, but in the young chickens it reduced expression of ghrelin and did not affect expression of GHS-R1a in the ovary. Administration of ghrelin 1–18 did not affect hypothalamic or ovarian ghrelin mRNA, but significantly increased the expression of GHS-R1a in hypothalamus, but not in ovary. (D-Lys-3)-GHRP-6, significantly stimulated accumulation of ghrelin, but not GHS-R1a mRNA in hypothalamus or ghrelin or GHS-R1a in the ovary. Ghrelin 1–18 and (D-Lys-3)-GHRP-6, when given together, were able either to prevent or to induce effect of these hormones. Obestatin administration increased expression of ghrelin gene in the hypothalamus, but not expression of hypothalamic GHS-R1a, ovarian ghrelin and GHS-R1a. Furthermore, obestatin was able to modify effect of both ghrelin and fasting on hypothalamic and ovarian mRNA for ghrelin GHS-R1a. Our results (1) confirm the existence of ghrelin and its functional receptors GHS-R1a in the chicken hypothalamus and ovary (2) confirm the age-dependent control of ovarian ghrelin by feeding, (3) demonstrate, that nutritional status can influence the expression of both ghrelin and GHS-R1a in hypothalamus and in the ovary (3) demonstrates for the first time, that ghrelin can promote generation of its functional receptor in the hypothalamus, but not in the ovary, (4) show that ghrelin1–18 and (D-Lys-3)-GHRP-6 could not only be antagonists in the action on chicken hypothalamus and ovaries, but also independent regulators and even agonists, and (5) provide first evidence for action of obestatin on hypothalamic ghrelin and on the response of hypothalamic and ovarian ghrelin/GHS-R1a system to food restriction. These data indicate the involvement of both hypothalamic and ovarian ghrelin/GHS-R1 systems in mediating the effects of nutritional status, ghrelin and obestatin on reproductive processes.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>22877785</pmid><doi>10.1016/j.cbpa.2012.07.010</doi><tpages>13</tpages></addata></record> |
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| ispartof | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2013-01, Vol.164 (1), p.141-153 |
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| subjects | Age Factors agonists Animals antagonists Chicken chickens Chickens - genetics Chickens - metabolism fasting Feeding Female Food Deprivation Gene Expression Regulation, Developmental genes Ghrelin Ghrelin - antagonists & inhibitors Ghrelin - metabolism Ghrelin - pharmacology Ghrelin receptor (GHS-R1a) ghrelin receptors Humans Hypothalamus Hypothalamus - cytology Hypothalamus - drug effects Hypothalamus - metabolism messenger RNA nutritional status Obestatin Oligopeptides - pharmacology ovarian follicles Ovary Ovary - cytology Ovary - metabolism Receptors, Ghrelin - genetics Receptors, Ghrelin - metabolism Recombinant Proteins - pharmacology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism |
| title | Food restriction, ghrelin, its antagonist and obestatin control expression of ghrelin and its receptor in chicken hypothalamus and ovary |
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