Inducible regulation of GDNF expression in human neural stem cells

Glial cell derived neurotrophic factor （GDNF） holds promises for treating neurodegenerative diseases such as Parkinson＇s dis- ease. Human neural stem cells （hNSCs） have proved to be a suitable cell delivery vehicle for the safe and efficient introduction of GDNF into the brain. In this study, we use...

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Veröffentlicht in:	Science China. Life sciences 2013, Vol.56 (1), p.32-39
Hauptverfasser:	Wang, ShuYan, Ren, Ping, Guan, YunQian, Zou, ChunLin, Fu, LinLin, Zhang, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Cell Proliferation Cells, Cultured Doxycycline - pharmacology GDNF Gene Expression Regulation Genetic Vectors - genetics Glial Cell Line-Derived Neurotrophic Factor - genetics Glial Cell Line-Derived Neurotrophic Factor - metabolism HEK293 Cells Humans Immunohistochemistry Intermediate Filament Proteins - genetics Intermediate Filament Proteins - metabolism Lentivirus Lentivirus - genetics Life Sciences Luminescent Proteins - genetics Luminescent Proteins - metabolism Microscopy, Fluorescence Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nestin Neural Stem Cells - cytology Neural Stem Cells - drug effects Neural Stem Cells - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Research Paper Reverse Transcriptase Polymerase Chain Reaction SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism Time Factors 人类潮霉素抗性基因神经干细胞神经退行性疾病胶质细胞源性神经营养因子诱导分化调控
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