Whole-brain functional imaging at cellular resolution using light-sheet microscopy

Whole-brain imaging of neuronal activity with cellular resolution at almost a brain per second is demonstrated using high-speed light-sheet microscopy in the larval zebrafish brain. Brain function relies on communication between large populations of neurons across multiple brain areas, a full unders...

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Veröffentlicht in:	Nature methods 2013-05, Vol.10 (5), p.413-420
Hauptverfasser:	Ahrens, Misha B, Orger, Michael B, Robson, Drew N, Li, Jennifer M, Keller, Philipp J
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/328/2237 631/378/116 692/700/1421/65 Activity patterns Animals Bioinformatics Biological Microscopy Biological Techniques Biomedical Engineering/Biotechnology Brain Brain - metabolism Brain - physiology Brain research Calcium Cell interaction Central nervous system Circuits Danio rerio Fish Fluorescence microscopy Genetic code Hindbrain Life Sciences Light sheets Methods Microscope and microscopy Microscopy Microscopy - methods Neuroimaging Neurology Neurons Neuropil Observations Physiological aspects Populations Proteomics Spinal cord Zebrafish
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