Randomized Phase III Trial of Single-Agent Pemetrexed Versus Carboplatin and Pemetrexed in Patients With Advanced Non–Small-Cell Lung Cancer and Eastern Cooperative Oncology Group Performance Status of 2

To compare single-agent pemetrexed (P) versus the combination of carboplatin and pemetrexed (CP) in first-line therapy for patients with advanced non-small-cell lung cancer (NSCLC) with an Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 2. In a multicenter phase III randomized t...

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Veröffentlicht in:	Journal of clinical oncology 2013-08, Vol.31 (23), p.2849-2853
Hauptverfasser:	ZUKIN, Mauro, BARRIOS, Carlos H, DA ROCHA BALDOTTO, Clarissa Serodio, METON VIEIRA, Fernando, SMALL, Isabele A, FERREIRA, Carlos G, LILENBAUM, Rogerio C, PEREIRA, Jose Rodrigues, DE ALBUQUERQUE RIBEIRO, Ronaldo, DE MENDONCA BEATO, Carlos Augusto, DO NASCIMENTO, Yeni Neron, MURAD, Andre, FRANKE, Fabio A, PRECIVALE, Maristela, DE LIMA ARAUJO, Luiz Henrique
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - adverse effects Antimetabolites, Antineoplastic - therapeutic use Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Carboplatin - administration & dosage Carboplatin - adverse effects Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - pathology Disease-Free Survival Female Glutamates - administration & dosage Glutamates - adverse effects Glutamates - therapeutic use Guanine - administration & dosage Guanine - adverse effects Guanine - analogs & derivatives Guanine - therapeutic use Humans Lung Neoplasms - drug therapy Lung Neoplasms - pathology Male Medical sciences Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Pemetrexed Pneumology Prospective Studies Survival Rate Tumors Tumors of the respiratory system and mediastinum
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