Endocrine regulation of estrogen synthesis in the hippocampus?
Estradiol synthesis in the ovaries is regulated via feedback mechanisms mediated by gonadotrophin-releasing hormone (GnRH) and gonadotrophins, secreted by the hypothalamus and the pituitary, respectively. Estradiol synthesis also takes place in the hippocampus. In hippocampal slice cultures of femal...
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| Veröffentlicht in: | Progress in histochemistry and cytochemistry 2013-08, Vol.48 (2), p.49-64 |
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| container_title | Progress in histochemistry and cytochemistry |
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| creator | Prange-Kiel, Janine Schmutterer, Tobias Fester, Lars Zhou, Lepu Imholz, Philipp Brandt, Nicola Vierk, Ricardo Jarry, Hubertus Rune, Gabriele M. |
| description | Estradiol synthesis in the ovaries is regulated via feedback mechanisms mediated by gonadotrophin-releasing hormone (GnRH) and gonadotrophins, secreted by the hypothalamus and the pituitary, respectively. Estradiol synthesis also takes place in the hippocampus. In hippocampal slice cultures of female animals, GnRH regulates estradiol synthesis dose-dependently. Hence, both hippocampal and ovarian estradiol synthesis are synchronized by GnRH. Hippocampus-derived estradiol is essential to synapse stability and maintenance because it stabilizes the spine cytoskeleton of hippocampal neurons. Inhibition of hippocampal estradiol synthesis in mice, however, results in loss of spines and spine synapses in females, but not in males. Stereotaxic application of GnRH to the hippocampus of female rats confirms the regulatory role of GnRH on estradiol synthesis and synapse density in the female hippocampus in vivo. This regulatory role of GnRH necessarily results in estrus cyclicity of spine density in the hippocampus of females. |
| doi_str_mv | 10.1016/j.proghi.2013.07.002 |
| format | Article |
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Estradiol synthesis also takes place in the hippocampus. In hippocampal slice cultures of female animals, GnRH regulates estradiol synthesis dose-dependently. Hence, both hippocampal and ovarian estradiol synthesis are synchronized by GnRH. Hippocampus-derived estradiol is essential to synapse stability and maintenance because it stabilizes the spine cytoskeleton of hippocampal neurons. Inhibition of hippocampal estradiol synthesis in mice, however, results in loss of spines and spine synapses in females, but not in males. Stereotaxic application of GnRH to the hippocampus of female rats confirms the regulatory role of GnRH on estradiol synthesis and synapse density in the female hippocampus in vivo. This regulatory role of GnRH necessarily results in estrus cyclicity of spine density in the hippocampus of females.</description><identifier>ISSN: 0079-6336</identifier><identifier>EISSN: 1873-2186</identifier><identifier>DOI: 10.1016/j.proghi.2013.07.002</identifier><identifier>PMID: 23906992</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Animals ; Dendritic Spines - drug effects ; Dendritic Spines - metabolism ; Dose-Response Relationship, Drug ; Estradiol - biosynthesis ; Female ; Gonadotropin-Releasing Hormone - pharmacology ; Hippocampus - cytology ; Hippocampus - drug effects ; Hippocampus - metabolism ; Immunohistochemistry ; Male ; Mice ; Neurons - drug effects ; Neurons - metabolism ; Rats ; Receptors, LHRH - genetics ; Receptors, LHRH - metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Sex Factors ; Synapses - drug effects ; Synapses - metabolism ; Tissue Culture Techniques</subject><ispartof>Progress in histochemistry and cytochemistry, 2013-08, Vol.48 (2), p.49-64</ispartof><rights>2013 Elsevier GmbH</rights><rights>Copyright © 2013 Elsevier GmbH. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-841c990c60e4e213b7d637ec168e0e77b67af8c70c0dc444a529fc703895e3a43</citedby><cites>FETCH-LOGICAL-c428t-841c990c60e4e213b7d637ec168e0e77b67af8c70c0dc444a529fc703895e3a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0079633613000132$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23906992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Prange-Kiel, Janine</creatorcontrib><creatorcontrib>Schmutterer, Tobias</creatorcontrib><creatorcontrib>Fester, Lars</creatorcontrib><creatorcontrib>Zhou, Lepu</creatorcontrib><creatorcontrib>Imholz, Philipp</creatorcontrib><creatorcontrib>Brandt, Nicola</creatorcontrib><creatorcontrib>Vierk, Ricardo</creatorcontrib><creatorcontrib>Jarry, Hubertus</creatorcontrib><creatorcontrib>Rune, Gabriele M.</creatorcontrib><title>Endocrine regulation of estrogen synthesis in the hippocampus?</title><title>Progress in histochemistry and cytochemistry</title><addtitle>Prog Histochem Cytochem</addtitle><description>Estradiol synthesis in the ovaries is regulated via feedback mechanisms mediated by gonadotrophin-releasing hormone (GnRH) and gonadotrophins, secreted by the hypothalamus and the pituitary, respectively. 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This regulatory role of GnRH necessarily results in estrus cyclicity of spine density in the hippocampus of females.</description><subject>Animals</subject><subject>Dendritic Spines - drug effects</subject><subject>Dendritic Spines - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>Estradiol - biosynthesis</subject><subject>Female</subject><subject>Gonadotropin-Releasing Hormone - pharmacology</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Mice</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Rats</subject><subject>Receptors, LHRH - genetics</subject><subject>Receptors, LHRH - metabolism</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Sex Factors</subject><subject>Synapses - drug effects</subject><subject>Synapses - metabolism</subject><subject>Tissue Culture Techniques</subject><issn>0079-6336</issn><issn>1873-2186</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EoqXwBwhlySZhHLt2vClCVXlIldjA2kqdSesqL-wEqX-PqxSWrGZGundm7iHklkJCgYqHfdK5druzSQqUJSATgPSMTGkmWZzSTJyTKYBUsWBMTMiV93sAypVQl2SSMgVCqXRKFqumaI2zDUYOt0OV97ZtoraM0PdhPTaRPzT9Dr31kW2i0EU723Wtyetu8I_X5KLMK483pzojn8-rj-VrvH5_eVs-rWPD06yPM06NUmAEIMeUso0sBJNoqMgQUMqNkHmZGQkGCsM5z-epKsPIMjVHlnM2I_fj3pD5awi_6dp6g1WVN9gOXlMeEnPJ1TxI-Sg1rvXeYak7Z-vcHTQFfSSn93okp4_kNEgdyAXb3enCsKmx-DP9ogqCxSjAkPPbotPeWGwMFtah6XXR2v8v_ADxdoDf</recordid><startdate>201308</startdate><enddate>201308</enddate><creator>Prange-Kiel, Janine</creator><creator>Schmutterer, Tobias</creator><creator>Fester, Lars</creator><creator>Zhou, Lepu</creator><creator>Imholz, Philipp</creator><creator>Brandt, Nicola</creator><creator>Vierk, Ricardo</creator><creator>Jarry, Hubertus</creator><creator>Rune, Gabriele M.</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201308</creationdate><title>Endocrine regulation of estrogen synthesis in the hippocampus?</title><author>Prange-Kiel, Janine ; Schmutterer, Tobias ; Fester, Lars ; Zhou, Lepu ; Imholz, Philipp ; Brandt, Nicola ; Vierk, Ricardo ; Jarry, Hubertus ; Rune, Gabriele M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-841c990c60e4e213b7d637ec168e0e77b67af8c70c0dc444a529fc703895e3a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Dendritic Spines - drug effects</topic><topic>Dendritic Spines - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>Estradiol - biosynthesis</topic><topic>Female</topic><topic>Gonadotropin-Releasing Hormone - pharmacology</topic><topic>Hippocampus - cytology</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Mice</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>Rats</topic><topic>Receptors, LHRH - genetics</topic><topic>Receptors, LHRH - metabolism</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Sex Factors</topic><topic>Synapses - drug effects</topic><topic>Synapses - metabolism</topic><topic>Tissue Culture Techniques</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prange-Kiel, Janine</creatorcontrib><creatorcontrib>Schmutterer, Tobias</creatorcontrib><creatorcontrib>Fester, Lars</creatorcontrib><creatorcontrib>Zhou, Lepu</creatorcontrib><creatorcontrib>Imholz, Philipp</creatorcontrib><creatorcontrib>Brandt, Nicola</creatorcontrib><creatorcontrib>Vierk, Ricardo</creatorcontrib><creatorcontrib>Jarry, Hubertus</creatorcontrib><creatorcontrib>Rune, Gabriele M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Progress in histochemistry and cytochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prange-Kiel, Janine</au><au>Schmutterer, Tobias</au><au>Fester, Lars</au><au>Zhou, Lepu</au><au>Imholz, Philipp</au><au>Brandt, Nicola</au><au>Vierk, Ricardo</au><au>Jarry, Hubertus</au><au>Rune, Gabriele M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endocrine regulation of estrogen synthesis in the hippocampus?</atitle><jtitle>Progress in histochemistry and cytochemistry</jtitle><addtitle>Prog Histochem Cytochem</addtitle><date>2013-08</date><risdate>2013</risdate><volume>48</volume><issue>2</issue><spage>49</spage><epage>64</epage><pages>49-64</pages><issn>0079-6336</issn><eissn>1873-2186</eissn><abstract>Estradiol synthesis in the ovaries is regulated via feedback mechanisms mediated by gonadotrophin-releasing hormone (GnRH) and gonadotrophins, secreted by the hypothalamus and the pituitary, respectively. Estradiol synthesis also takes place in the hippocampus. In hippocampal slice cultures of female animals, GnRH regulates estradiol synthesis dose-dependently. Hence, both hippocampal and ovarian estradiol synthesis are synchronized by GnRH. Hippocampus-derived estradiol is essential to synapse stability and maintenance because it stabilizes the spine cytoskeleton of hippocampal neurons. Inhibition of hippocampal estradiol synthesis in mice, however, results in loss of spines and spine synapses in females, but not in males. Stereotaxic application of GnRH to the hippocampus of female rats confirms the regulatory role of GnRH on estradiol synthesis and synapse density in the female hippocampus in vivo. This regulatory role of GnRH necessarily results in estrus cyclicity of spine density in the hippocampus of females.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>23906992</pmid><doi>10.1016/j.proghi.2013.07.002</doi><tpages>16</tpages></addata></record> |
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| subjects | Animals Dendritic Spines - drug effects Dendritic Spines - metabolism Dose-Response Relationship, Drug Estradiol - biosynthesis Female Gonadotropin-Releasing Hormone - pharmacology Hippocampus - cytology Hippocampus - drug effects Hippocampus - metabolism Immunohistochemistry Male Mice Neurons - drug effects Neurons - metabolism Rats Receptors, LHRH - genetics Receptors, LHRH - metabolism Reverse Transcriptase Polymerase Chain Reaction Sex Factors Synapses - drug effects Synapses - metabolism Tissue Culture Techniques |
| title | Endocrine regulation of estrogen synthesis in the hippocampus? |
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