The Effects of the Antiplatelet Agents, Aspirin and Naproxen, on Pharmacokinetics and Pharmacodynamics of the Anticoagulant Edoxaban, a Direct Factor Xa Inhibitor

Edoxaban is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention in patients with atrial fibrillation, an elderly population that frequently receives aspirin (ASA) and/or nonsteroidal anti-inflammatory drugs for concurrent illnesses. Three studies were conducted to evaluat...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 2013-08, Vol.62 (2), p.212-221
Hauptverfasser:	Mendell, Jeanne, Lee, Frank, Chen, Shuquan, Worland, Valerie, Shi, Minggao, Samama, Meyer M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - adverse effects Anticoagulants - adverse effects Anticoagulants - blood Anticoagulants - pharmacokinetics Aspirin - administration & dosage Aspirin - adverse effects Biological and medical sciences Blood Physiological Phenomena - drug effects Cardiovascular system Cohort Studies Cross-Over Studies Dose-Response Relationship, Drug Double-Blind Method Drug Interactions Drug Therapy, Combination - adverse effects Factor Xa Inhibitors Female Humans Male Medical sciences Middle Aged Naproxen - administration & dosage Naproxen - adverse effects Pharmacology. Drug treatments Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - adverse effects Pyridines - adverse effects Pyridines - blood Pyridines - pharmacokinetics Thiazoles - adverse effects Thiazoles - blood Thiazoles - pharmacokinetics Young Adult
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