MicroRNA profiling in ocular adnexal lymphoma: a role for MYC and NFKB1 mediated dysregulation of microRNA expression in aggressive disease

Ocular adnexal lymphoma (i.e., lymphoma with involvement of the orbit, eyelids, conjunctiva, lacrimal gland, and lacrimal sac), although rare, is common among malignant tumors involving the ocular adnexal region. The main subtypes are low-grade extranodal marginal zone lymphoma (EMZL) and aggressive...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2013-08, Vol.54 (8), p.5169-5175
Hauptverfasser:	Hother, Christoffer, Rasmussen, Peter Kristian, Joshi, Tejal, Reker, Ditte, Ralfkiær, Ulrik, Workman, Christopher T, Heegaard, Steffen, Ralfkiær, Elisabeth, Grønbæk, Kirsten
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Conjunctival Neoplasms - genetics Conjunctival Neoplasms - metabolism Conjunctival Neoplasms - pathology Eye Neoplasms - genetics Eye Neoplasms - metabolism Eye Neoplasms - pathology Female Follow-Up Studies Gene Expression Regulation, Neoplastic Humans Lacrimal Apparatus - metabolism Lacrimal Apparatus - pathology Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - metabolism Lymphoma, Large B-Cell, Diffuse - pathology Male MicroRNAs - biosynthesis MicroRNAs - genetics Middle Aged NF-kappa B p50 Subunit - biosynthesis NF-kappa B p50 Subunit - genetics Orbital Neoplasms - genetics Orbital Neoplasms - metabolism Orbital Neoplasms - pathology Protein Array Analysis - methods Proto-Oncogene Proteins c-myc - biosynthesis Proto-Oncogene Proteins c-myc - genetics Real-Time Polymerase Chain Reaction RNA, Neoplasm - biosynthesis RNA, Neoplasm - genetics
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