Supraadditive formation of micronuclei in preimplantation mouse embryos in vitro after combined treatment with X-rays and caffeine

The influence of caffeine (0.1 or 2 mM), X‐rays (0.24 Gy [ = 25 R] or 0.94 Gy [ = 100 R]), or of a combination of both on the formation of micronuclei in early stages of preimplantation mouse embryos in vitro was studied. X‐rays as well as caffeine induced micronuclei. The dose‐effect curve after ir...

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Veröffentlicht in:	Teratog., Carcinog., Mutagen.; (United States) Carcinog., Mutagen.; (United States), 1985, Vol.5 (2), p.123-131
Hauptverfasser:	Müller, W.-U., Streffer, C., Wurm, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	560152 - Radiation Effects on Animals- Animals ANALEPTICS ANIMALS AROMATICS AZAARENES Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS Blastocyst - drug effects Blastocyst - radiation effects CAFFEINE Caffeine - toxicity CELL CONSTITUENTS CELL NUCLEI CENTRAL NERVOUS SYSTEM AGENTS CHROMOSOMAL ABERRATIONS Chromosome Aberrations combined treatment Dose-Response Relationship, Drug DOSE-RESPONSE RELATIONSHIPS DRUGS ELECTROMAGNETIC RADIATION Embryology: invertebrates and vertebrates. Teratology EMBRYOS Fundamental and applied biological sciences. Psychology HETEROCYCLIC COMPOUNDS IN VITRO In Vitro Techniques IONIZING RADIATIONS isobologram MAMMALS MICE micronucleus Mutagenicity Tests MUTATIONS ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANIC OXYGEN COMPOUNDS preimplantation mouse embryo PURINES RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RODENTS supraadditivity SYNERGISM Teratology. Teratogens VERTEBRATES X RADIATION X-Rays XANTHINES
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