Impact of chorionicity on first-trimester nuchal translucency screening in ART twin pregnancies
ABSTRACT Objective Nuchal translucency (NT) measurement in assisted reproduction treatment (ART) twins is less extensively investigated. Therefore, the present study compared NT measurements of spontaneously conceived twins with ART twins in dichorionic (DC) and monochorionic (MC) pregnancies. Metho...
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| Veröffentlicht in: | Prenatal diagnosis 2013-08, Vol.33 (8), p.722-725 |
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| description | ABSTRACT
Objective
Nuchal translucency (NT) measurement in assisted reproduction treatment (ART) twins is less extensively investigated. Therefore, the present study compared NT measurements of spontaneously conceived twins with ART twins in dichorionic (DC) and monochorionic (MC) pregnancies.
Methods
Retrospective analysis of 706 unaffected twins between 11 + 0 and 13 + 6 weeks conceived either spontaneously (n = 362) or with ART (n = 344). The group with spontaneous conception included 234 DC (64.6%) and 128 MC (35.4%) pregnancies. In the ART group, 326 were DC (94.7%) and 18 were MC (5.3%). NT values were transformed into multiples of median (MoM).
Results
In the DC group, no significant differences between ART and spontaneously conceived twins (NT MoM 1.06 ± 0.28 vs 1.03 ± 0.29; p > 0.05) were observed. NT MoM of MC ART twins was higher compared with spontaneous MC twins (1.23 ± 0.82 vs 0.99 ± 0.27; p = 0.011). Although the incidence of twin‐to‐twin transfusion syndrome (TTTS) was higher among ART twins (11.1% vs 4.7%), inter‐twin NT difference was similar between pregnancies with TTTS (0.42 ± 0.21) or without (0.40 ± 0.71).
Conclusions
Measurement of NT thickness in DC ART twins achieves comparable results with twins conceived spontaneously. Conclusions in MC twins are limited; however, higher NT MoM was not related to TTTS or selective intrauterine growth restriction. © 2013 John Wiley & Sons, Ltd.
What's already known about this topic?
Measurement of nuchal translucency (NT) is an effective and validated method to detect chromosomal abnormalities in singletons and twins. Most studies reported comparable screening results in assisted reproduction treatment (ART) singletons compared with spontaneous conceptions. However, ART twins are less extensively investigated, especially with respect to chorionicity.
What does this study add?
This study is the first analysis about the impact of chorionicity on NT screening in ART and spontaneous twins in a large cohort. |
| doi_str_mv | 10.1002/pd.4107 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1418147859</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1418147859</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3837-141813199244c04fa0bc7bb734db183ed757503660be04cd6f6c8444462051473</originalsourceid><addsrcrecordid>eNp10M1KxDAUBeAgio6j-AYScKEg1dwmbdql-DOODCqiCG5CmqYa7aQ1adF5ezPO6EIwm3sXHyeXg9AOkCMgJD5uyyMGhK-gAZCcRySO6SoaEAg7zRLYQJvevwaYxTlfRxsxTSkBSAdIjKetVB1uKqxeGmcaa5TpZrixuDLOd1HnzFT7Tjtse_Uia9w5aX3dK23VDHvltLbGPmNj8cndPe4-wtI6_WylVUb7LbRWydrr7eUcooeL8_vTy2hyMxqfnkwiRTPKI2CQAYU8jxlThFWSFIoXBaesLCCjuuQJTwhNU1JowlSZVqnKWHhpTBJgnA7RwSK3dc17Hw4WU-OVrmtpddN78f0B41mSB7r3h742vbPhurlKOYWYQFD7C6Vc473TlWhDE9LNBBAx71y0pZh3HuTuMq8vprr8dT8lB3C4AB-m1rP_csTt2TIuWmgTWv_81dK9iXAbT8Tj9UhccZiws6dHMaJf9xSW5A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1416731201</pqid></control><display><type>article</type><title>Impact of chorionicity on first-trimester nuchal translucency screening in ART twin pregnancies</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Flöck, A. ; Reinsberg, J. ; Berg, C. ; Gembruch, U. ; Geipel, A.</creator><creatorcontrib>Flöck, A. ; Reinsberg, J. ; Berg, C. ; Gembruch, U. ; Geipel, A.</creatorcontrib><description>ABSTRACT
Objective
Nuchal translucency (NT) measurement in assisted reproduction treatment (ART) twins is less extensively investigated. Therefore, the present study compared NT measurements of spontaneously conceived twins with ART twins in dichorionic (DC) and monochorionic (MC) pregnancies.
Methods
Retrospective analysis of 706 unaffected twins between 11 + 0 and 13 + 6 weeks conceived either spontaneously (n = 362) or with ART (n = 344). The group with spontaneous conception included 234 DC (64.6%) and 128 MC (35.4%) pregnancies. In the ART group, 326 were DC (94.7%) and 18 were MC (5.3%). NT values were transformed into multiples of median (MoM).
Results
In the DC group, no significant differences between ART and spontaneously conceived twins (NT MoM 1.06 ± 0.28 vs 1.03 ± 0.29; p > 0.05) were observed. NT MoM of MC ART twins was higher compared with spontaneous MC twins (1.23 ± 0.82 vs 0.99 ± 0.27; p = 0.011). Although the incidence of twin‐to‐twin transfusion syndrome (TTTS) was higher among ART twins (11.1% vs 4.7%), inter‐twin NT difference was similar between pregnancies with TTTS (0.42 ± 0.21) or without (0.40 ± 0.71).
Conclusions
Measurement of NT thickness in DC ART twins achieves comparable results with twins conceived spontaneously. Conclusions in MC twins are limited; however, higher NT MoM was not related to TTTS or selective intrauterine growth restriction. © 2013 John Wiley & Sons, Ltd.
What's already known about this topic?
Measurement of nuchal translucency (NT) is an effective and validated method to detect chromosomal abnormalities in singletons and twins. Most studies reported comparable screening results in assisted reproduction treatment (ART) singletons compared with spontaneous conceptions. However, ART twins are less extensively investigated, especially with respect to chorionicity.
What does this study add?
This study is the first analysis about the impact of chorionicity on NT screening in ART and spontaneous twins in a large cohort.</description><identifier>ISSN: 0197-3851</identifier><identifier>EISSN: 1097-0223</identifier><identifier>DOI: 10.1002/pd.4107</identifier><identifier>PMID: 23630116</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Chorion - diagnostic imaging ; Female ; Fetofetal Transfusion - diagnostic imaging ; Fetofetal Transfusion - epidemiology ; Humans ; Nuchal Translucency Measurement - statistics & numerical data ; Pregnancy ; Pregnancy Trimester, First ; Pregnancy, Twin - statistics & numerical data ; Reproductive Techniques, Assisted - statistics & numerical data ; Retrospective Studies ; Twins, Dizygotic - statistics & numerical data ; Twins, Monozygotic - statistics & numerical data</subject><ispartof>Prenatal diagnosis, 2013-08, Vol.33 (8), p.722-725</ispartof><rights>2013 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3837-141813199244c04fa0bc7bb734db183ed757503660be04cd6f6c8444462051473</citedby><cites>FETCH-LOGICAL-c3837-141813199244c04fa0bc7bb734db183ed757503660be04cd6f6c8444462051473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpd.4107$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpd.4107$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23630116$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Flöck, A.</creatorcontrib><creatorcontrib>Reinsberg, J.</creatorcontrib><creatorcontrib>Berg, C.</creatorcontrib><creatorcontrib>Gembruch, U.</creatorcontrib><creatorcontrib>Geipel, A.</creatorcontrib><title>Impact of chorionicity on first-trimester nuchal translucency screening in ART twin pregnancies</title><title>Prenatal diagnosis</title><addtitle>Prenat Diagn</addtitle><description>ABSTRACT
Objective
Nuchal translucency (NT) measurement in assisted reproduction treatment (ART) twins is less extensively investigated. Therefore, the present study compared NT measurements of spontaneously conceived twins with ART twins in dichorionic (DC) and monochorionic (MC) pregnancies.
Methods
Retrospective analysis of 706 unaffected twins between 11 + 0 and 13 + 6 weeks conceived either spontaneously (n = 362) or with ART (n = 344). The group with spontaneous conception included 234 DC (64.6%) and 128 MC (35.4%) pregnancies. In the ART group, 326 were DC (94.7%) and 18 were MC (5.3%). NT values were transformed into multiples of median (MoM).
Results
In the DC group, no significant differences between ART and spontaneously conceived twins (NT MoM 1.06 ± 0.28 vs 1.03 ± 0.29; p > 0.05) were observed. NT MoM of MC ART twins was higher compared with spontaneous MC twins (1.23 ± 0.82 vs 0.99 ± 0.27; p = 0.011). Although the incidence of twin‐to‐twin transfusion syndrome (TTTS) was higher among ART twins (11.1% vs 4.7%), inter‐twin NT difference was similar between pregnancies with TTTS (0.42 ± 0.21) or without (0.40 ± 0.71).
Conclusions
Measurement of NT thickness in DC ART twins achieves comparable results with twins conceived spontaneously. Conclusions in MC twins are limited; however, higher NT MoM was not related to TTTS or selective intrauterine growth restriction. © 2013 John Wiley & Sons, Ltd.
What's already known about this topic?
Measurement of nuchal translucency (NT) is an effective and validated method to detect chromosomal abnormalities in singletons and twins. Most studies reported comparable screening results in assisted reproduction treatment (ART) singletons compared with spontaneous conceptions. However, ART twins are less extensively investigated, especially with respect to chorionicity.
What does this study add?
This study is the first analysis about the impact of chorionicity on NT screening in ART and spontaneous twins in a large cohort.</description><subject>Adult</subject><subject>Chorion - diagnostic imaging</subject><subject>Female</subject><subject>Fetofetal Transfusion - diagnostic imaging</subject><subject>Fetofetal Transfusion - epidemiology</subject><subject>Humans</subject><subject>Nuchal Translucency Measurement - statistics & numerical data</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First</subject><subject>Pregnancy, Twin - statistics & numerical data</subject><subject>Reproductive Techniques, Assisted - statistics & numerical data</subject><subject>Retrospective Studies</subject><subject>Twins, Dizygotic - statistics & numerical data</subject><subject>Twins, Monozygotic - statistics & numerical data</subject><issn>0197-3851</issn><issn>1097-0223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10M1KxDAUBeAgio6j-AYScKEg1dwmbdql-DOODCqiCG5CmqYa7aQ1adF5ezPO6EIwm3sXHyeXg9AOkCMgJD5uyyMGhK-gAZCcRySO6SoaEAg7zRLYQJvevwaYxTlfRxsxTSkBSAdIjKetVB1uKqxeGmcaa5TpZrixuDLOd1HnzFT7Tjtse_Uia9w5aX3dK23VDHvltLbGPmNj8cndPe4-wtI6_WylVUb7LbRWydrr7eUcooeL8_vTy2hyMxqfnkwiRTPKI2CQAYU8jxlThFWSFIoXBaesLCCjuuQJTwhNU1JowlSZVqnKWHhpTBJgnA7RwSK3dc17Hw4WU-OVrmtpddN78f0B41mSB7r3h742vbPhurlKOYWYQFD7C6Vc473TlWhDE9LNBBAx71y0pZh3HuTuMq8vprr8dT8lB3C4AB-m1rP_csTt2TIuWmgTWv_81dK9iXAbT8Tj9UhccZiws6dHMaJf9xSW5A</recordid><startdate>201308</startdate><enddate>201308</enddate><creator>Flöck, A.</creator><creator>Reinsberg, J.</creator><creator>Berg, C.</creator><creator>Gembruch, U.</creator><creator>Geipel, A.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201308</creationdate><title>Impact of chorionicity on first-trimester nuchal translucency screening in ART twin pregnancies</title><author>Flöck, A. ; Reinsberg, J. ; Berg, C. ; Gembruch, U. ; Geipel, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3837-141813199244c04fa0bc7bb734db183ed757503660be04cd6f6c8444462051473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Chorion - diagnostic imaging</topic><topic>Female</topic><topic>Fetofetal Transfusion - diagnostic imaging</topic><topic>Fetofetal Transfusion - epidemiology</topic><topic>Humans</topic><topic>Nuchal Translucency Measurement - statistics & numerical data</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First</topic><topic>Pregnancy, Twin - statistics & numerical data</topic><topic>Reproductive Techniques, Assisted - statistics & numerical data</topic><topic>Retrospective Studies</topic><topic>Twins, Dizygotic - statistics & numerical data</topic><topic>Twins, Monozygotic - statistics & numerical data</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Flöck, A.</creatorcontrib><creatorcontrib>Reinsberg, J.</creatorcontrib><creatorcontrib>Berg, C.</creatorcontrib><creatorcontrib>Gembruch, U.</creatorcontrib><creatorcontrib>Geipel, A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Prenatal diagnosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Flöck, A.</au><au>Reinsberg, J.</au><au>Berg, C.</au><au>Gembruch, U.</au><au>Geipel, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of chorionicity on first-trimester nuchal translucency screening in ART twin pregnancies</atitle><jtitle>Prenatal diagnosis</jtitle><addtitle>Prenat Diagn</addtitle><date>2013-08</date><risdate>2013</risdate><volume>33</volume><issue>8</issue><spage>722</spage><epage>725</epage><pages>722-725</pages><issn>0197-3851</issn><eissn>1097-0223</eissn><abstract>ABSTRACT
Objective
Nuchal translucency (NT) measurement in assisted reproduction treatment (ART) twins is less extensively investigated. Therefore, the present study compared NT measurements of spontaneously conceived twins with ART twins in dichorionic (DC) and monochorionic (MC) pregnancies.
Methods
Retrospective analysis of 706 unaffected twins between 11 + 0 and 13 + 6 weeks conceived either spontaneously (n = 362) or with ART (n = 344). The group with spontaneous conception included 234 DC (64.6%) and 128 MC (35.4%) pregnancies. In the ART group, 326 were DC (94.7%) and 18 were MC (5.3%). NT values were transformed into multiples of median (MoM).
Results
In the DC group, no significant differences between ART and spontaneously conceived twins (NT MoM 1.06 ± 0.28 vs 1.03 ± 0.29; p > 0.05) were observed. NT MoM of MC ART twins was higher compared with spontaneous MC twins (1.23 ± 0.82 vs 0.99 ± 0.27; p = 0.011). Although the incidence of twin‐to‐twin transfusion syndrome (TTTS) was higher among ART twins (11.1% vs 4.7%), inter‐twin NT difference was similar between pregnancies with TTTS (0.42 ± 0.21) or without (0.40 ± 0.71).
Conclusions
Measurement of NT thickness in DC ART twins achieves comparable results with twins conceived spontaneously. Conclusions in MC twins are limited; however, higher NT MoM was not related to TTTS or selective intrauterine growth restriction. © 2013 John Wiley & Sons, Ltd.
What's already known about this topic?
Measurement of nuchal translucency (NT) is an effective and validated method to detect chromosomal abnormalities in singletons and twins. Most studies reported comparable screening results in assisted reproduction treatment (ART) singletons compared with spontaneous conceptions. However, ART twins are less extensively investigated, especially with respect to chorionicity.
What does this study add?
This study is the first analysis about the impact of chorionicity on NT screening in ART and spontaneous twins in a large cohort.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>23630116</pmid><doi>10.1002/pd.4107</doi><tpages>4</tpages></addata></record> |
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| ispartof | Prenatal diagnosis, 2013-08, Vol.33 (8), p.722-725 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Chorion - diagnostic imaging Female Fetofetal Transfusion - diagnostic imaging Fetofetal Transfusion - epidemiology Humans Nuchal Translucency Measurement - statistics & numerical data Pregnancy Pregnancy Trimester, First Pregnancy, Twin - statistics & numerical data Reproductive Techniques, Assisted - statistics & numerical data Retrospective Studies Twins, Dizygotic - statistics & numerical data Twins, Monozygotic - statistics & numerical data |
| title | Impact of chorionicity on first-trimester nuchal translucency screening in ART twin pregnancies |
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