Non-peptidyl insulin mimetics as a potential antidiabetic agent

•Benzoquinone analog is identified as an activator of insulin receptor tyrosine kinase.•Modification of this molecule provided potent and specific activators of receptor.•Vanadium mimics insulin actions by inhibiting protein tyrosine phosphatases.•Specific activators of protein tyrosine phosphatase...

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Veröffentlicht in:	Drug discovery today 2013-08, Vol.18 (15-16), p.748-755
Hauptverfasser:	Nankar, Rakesh P., Doble, Mukesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomimetic Materials - chemistry Biomimetic Materials - therapeutic use Biomimetics - methods Diabetes Mellitus - blood Diabetes Mellitus - drug therapy Humans Hypoglycemic Agents - chemistry Hypoglycemic Agents - therapeutic use Insulin - chemistry Insulin - therapeutic use Structure-Activity Relationship
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