Late endosomal transport and tethering are coupled processes controlled by RILP and the cholesterol sensor ORP1L

Late endosomes and lysosomes are dynamic organelles that constantly move and fuse to acquire cargo from early endosomes, phagosomes and autophagosome. Defects in lysosomal dynamics cause severe neurodegenerative and developmental diseases, such as Niemann-Pick type C disease and ARC syndrome, yet li...

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Veröffentlicht in:	Journal of cell science 2013-08, Vol.126 (Pt 15), p.3462-3474
Hauptverfasser:	van der Kant, Rik, Fish, Alexander, Janssen, Lennert, Janssen, Hans, Krom, Sabine, Ho, Nataschja, Brummelkamp, Thijn, Carette, Jan, Rocha, Nuno, Neefjes, Jacques
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Cell Line, Tumor Cholesterol - metabolism Dyneins - genetics Dyneins - metabolism Endosomes - metabolism Humans Melanoma - genetics Melanoma - metabolism rab GTP-Binding Proteins - genetics rab GTP-Binding Proteins - metabolism Receptors, Steroid - genetics Receptors, Steroid - metabolism Transport Vesicles - metabolism
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