The impact of adrenergic signaling in skin cancer progression: Possible repurposing of β-blockers for treatment of skin cancer
Studies suggest that psychosocial factors can impact cancer progression. Parallel work in the fields of psychoneuroimmunology and developmental neuroscience have led to the implication of catecholamine hormones (norepinephrine and epinephrine) and their receptors (the β-adrenergic receptors; β-ARs)...
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| Veröffentlicht in: | Cancer biomarkers : section A of Disease markers 2013-01, Vol.13 (3), p.155-160 |
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| container_end_page | 160 |
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| container_title | Cancer biomarkers : section A of Disease markers |
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| creator | Yang, Eric V. Eubank, Tim D. |
| description | Studies suggest that psychosocial factors can impact cancer progression. Parallel work in the fields of psychoneuroimmunology and developmental neuroscience have led to the implication of catecholamine hormones (norepinephrine and epinephrine) and their receptors (the β-adrenergic receptors; β-ARs) in regulating cancer progression. In this review we discuss studies that describe the effects of psychological stress as mediated by factors including the catecholamines norepinephrine and epinephrine on various aspects of tumor progression including proliferation, angiogenesis, and metastasis. We discuss the role of β-ARs in facilitating these effects and the potential use of β-blockers in adjuvant cancer therapy. |
| doi_str_mv | 10.3233/CBM-130325 |
| format | Article |
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| identifier | ISSN: 1574-0153 |
| ispartof | Cancer biomarkers : section A of Disease markers, 2013-01, Vol.13 (3), p.155-160 |
| issn | 1574-0153 1875-8592 |
| language | eng |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Adrenergic beta-Antagonists - pharmacology Adrenergic beta-Antagonists - therapeutic use Animals Disease Progression Humans Signal Transduction Skin Neoplasms - drug therapy Skin Neoplasms - metabolism Skin Neoplasms - pathology Skin Neoplasms - psychology Stress, Psychological - metabolism Stress, Psychological - pathology |
| title | The impact of adrenergic signaling in skin cancer progression: Possible repurposing of β-blockers for treatment of skin cancer |
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