Is Head and Neck Melanoma Different from Trunk and Extremity Melanomas with Respect to Sentinel Lymph Node Status and Clinical Outcome?
Background Previous studies showed conflicting and inconsistent results regarding the effect of anatomic location of the melanoma on sentinel lymph node (SLN) positivity and/or survival. This study was conducted to evaluate and compare the effect of the anatomic locations of primary melanoma on long...
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| Veröffentlicht in: | Annals of surgical oncology 2013-09, Vol.20 (9), p.3089-3097 |
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| creator | Fadaki, Niloofar Li, Rui Parrett, Brian Sanders, Grant Thummala, Suresh Martineau, Lea Cardona-Huerta, Servando Miranda, Suzette Cheng, Shih-Tsung Miller, James R. Singer, Mark Cleaver, James E. Kashani-Sabet, Mohammed Leong, Stanley P. L. |
| description | Background
Previous studies showed conflicting and inconsistent results regarding the effect of anatomic location of the melanoma on sentinel lymph node (SLN) positivity and/or survival. This study was conducted to evaluate and compare the effect of the anatomic locations of primary melanoma on long-term clinical outcomes.
Methods
All consecutive cutaneous melanoma patients (
n
= 2,079) who underwent selective SLN dissection (SLND) from 1993 to 2009 in a single academic tertiary-care medical center were included. SLN positive rate, disease-free survival (DFS), and overall survival (OS) were determined. Kaplan-Meier survival, univariate, and multivariate analyses were performed to determine predictive factors for SLN status, DFS, and OS.
Results
Head and neck melanoma (HNM) had the lowest SLN-positive rate at 10.8 % (16.8 % for extremity and 19.3 % for trunk;
P
= 0.002) but had the worst 5-year DFS (
P
|
| doi_str_mv | 10.1245/s10434-013-2977-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1418143220</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3035992141</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-56bd27a44df5224ab3ba9ca363798a5036dd7d67a4f05f693e80e9387b9aa8013</originalsourceid><addsrcrecordid>eNp1kctO3DAUhi1UxP0BuqksddNNim-x41VVTaEgDSBxWVtOfFICSTzYjtp5Al4bDwOoQmJly-f7_3OOf4Q-U_KdMlEeRkoEFwWhvGBaqUJtoB1a5hchK_op34msCs1kuY12Y7wjhCpOyi20zbgUWnOygx5PIz4B67AdHT6H5h6fQW9HP1j8q2tbCDAm3AY_4OswjffP2NG_FGDo0vKNjfhvl27xJcQFNAknj6-yrhuhx_PlsLjF594Bvko2TfHZYtZ3Y9fYHl9MqfED_NhHm63tIxy8nHvo5vjoenZSzC9-n85-zouGK5aKUtaOKSuEa0vGhK15bXVjueRKV7YkXDqnnMxES8pWag4VAc0rVWtrq_xRe-jb2ncR_MMEMZmhiw30eQ_wUzRU0IoKzhjJ6Nd36J2fwpinW1FKEKorkSm6pprgYwzQmkXoBhuWhhKzSsmsUzK5uVmlZFTWfHlxnuoB3JviNZYMsDUQc2n8A-G_1h-6PgGcGpxz</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1417401984</pqid></control><display><type>article</type><title>Is Head and Neck Melanoma Different from Trunk and Extremity Melanomas with Respect to Sentinel Lymph Node Status and Clinical Outcome?</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Fadaki, Niloofar ; Li, Rui ; Parrett, Brian ; Sanders, Grant ; Thummala, Suresh ; Martineau, Lea ; Cardona-Huerta, Servando ; Miranda, Suzette ; Cheng, Shih-Tsung ; Miller, James R. ; Singer, Mark ; Cleaver, James E. ; Kashani-Sabet, Mohammed ; Leong, Stanley P. L.</creator><creatorcontrib>Fadaki, Niloofar ; Li, Rui ; Parrett, Brian ; Sanders, Grant ; Thummala, Suresh ; Martineau, Lea ; Cardona-Huerta, Servando ; Miranda, Suzette ; Cheng, Shih-Tsung ; Miller, James R. ; Singer, Mark ; Cleaver, James E. ; Kashani-Sabet, Mohammed ; Leong, Stanley P. L.</creatorcontrib><description><![CDATA[Background
Previous studies showed conflicting and inconsistent results regarding the effect of anatomic location of the melanoma on sentinel lymph node (SLN) positivity and/or survival. This study was conducted to evaluate and compare the effect of the anatomic locations of primary melanoma on long-term clinical outcomes.
Methods
All consecutive cutaneous melanoma patients (
n
= 2,079) who underwent selective SLN dissection (SLND) from 1993 to 2009 in a single academic tertiary-care medical center were included. SLN positive rate, disease-free survival (DFS), and overall survival (OS) were determined. Kaplan-Meier survival, univariate, and multivariate analyses were performed to determine predictive factors for SLN status, DFS, and OS.
Results
Head and neck melanoma (HNM) had the lowest SLN-positive rate at 10.8 % (16.8 % for extremity and 19.3 % for trunk;
P
= 0.002) but had the worst 5-year DFS (
P
< 0.0001) and 5-year OS (
P
< 0.0001) compared with other sites. Tumor thickness (
P
< 0.001), ulceration (
P
< 0.001), HNM location (
P
= 0.001), mitotic rate (
P
< 0.001), and decreasing age (
P
< 0.001) were independent predictive factors for SLN-positivity. HNM with T3 or T4 thickness had significantly lower SLN positive rate compared with other locations (
P
≤ 0.05). Also, on multivariate analysis, HNM location versus other anatomic sites was independently predictive of decreased DFS and OS (
P
< 0.001). By Kaplan-Meier analysis, HNM was associated significantly with the worst DFS and OS.
Conclusions
Primary melanoma anatomic location is an independent predictor of SLN status and survival. Although HNM has a decreased SLN-positivity rate, it shows a significantly increased risk of recurrence and death as compared with other sites.]]></description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-013-2977-7</identifier><identifier>PMID: 23649930</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Clinical outcomes ; Extremities - pathology ; Extremities - surgery ; Female ; Follow-Up Studies ; Head and Neck Neoplasms - mortality ; Head and Neck Neoplasms - pathology ; Head and Neck Neoplasms - surgery ; Humans ; Lymphatic Metastasis ; Male ; Medicine ; Medicine & Public Health ; Melanoma - mortality ; Melanoma - pathology ; Melanoma - surgery ; Melanomas ; Middle Aged ; Neoplasm Staging ; Oncology ; Prognosis ; Sentinel Lymph Node Biopsy ; Skin Neoplasms - mortality ; Skin Neoplasms - pathology ; Skin Neoplasms - surgery ; Surgery ; Surgical Oncology ; Survival Rate ; Tertiary Care Centers</subject><ispartof>Annals of surgical oncology, 2013-09, Vol.20 (9), p.3089-3097</ispartof><rights>Society of Surgical Oncology 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-56bd27a44df5224ab3ba9ca363798a5036dd7d67a4f05f693e80e9387b9aa8013</citedby><cites>FETCH-LOGICAL-c372t-56bd27a44df5224ab3ba9ca363798a5036dd7d67a4f05f693e80e9387b9aa8013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-013-2977-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-013-2977-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23649930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fadaki, Niloofar</creatorcontrib><creatorcontrib>Li, Rui</creatorcontrib><creatorcontrib>Parrett, Brian</creatorcontrib><creatorcontrib>Sanders, Grant</creatorcontrib><creatorcontrib>Thummala, Suresh</creatorcontrib><creatorcontrib>Martineau, Lea</creatorcontrib><creatorcontrib>Cardona-Huerta, Servando</creatorcontrib><creatorcontrib>Miranda, Suzette</creatorcontrib><creatorcontrib>Cheng, Shih-Tsung</creatorcontrib><creatorcontrib>Miller, James R.</creatorcontrib><creatorcontrib>Singer, Mark</creatorcontrib><creatorcontrib>Cleaver, James E.</creatorcontrib><creatorcontrib>Kashani-Sabet, Mohammed</creatorcontrib><creatorcontrib>Leong, Stanley P. L.</creatorcontrib><title>Is Head and Neck Melanoma Different from Trunk and Extremity Melanomas with Respect to Sentinel Lymph Node Status and Clinical Outcome?</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description><![CDATA[Background
Previous studies showed conflicting and inconsistent results regarding the effect of anatomic location of the melanoma on sentinel lymph node (SLN) positivity and/or survival. This study was conducted to evaluate and compare the effect of the anatomic locations of primary melanoma on long-term clinical outcomes.
Methods
All consecutive cutaneous melanoma patients (
n
= 2,079) who underwent selective SLN dissection (SLND) from 1993 to 2009 in a single academic tertiary-care medical center were included. SLN positive rate, disease-free survival (DFS), and overall survival (OS) were determined. Kaplan-Meier survival, univariate, and multivariate analyses were performed to determine predictive factors for SLN status, DFS, and OS.
Results
Head and neck melanoma (HNM) had the lowest SLN-positive rate at 10.8 % (16.8 % for extremity and 19.3 % for trunk;
P
= 0.002) but had the worst 5-year DFS (
P
< 0.0001) and 5-year OS (
P
< 0.0001) compared with other sites. Tumor thickness (
P
< 0.001), ulceration (
P
< 0.001), HNM location (
P
= 0.001), mitotic rate (
P
< 0.001), and decreasing age (
P
< 0.001) were independent predictive factors for SLN-positivity. HNM with T3 or T4 thickness had significantly lower SLN positive rate compared with other locations (
P
≤ 0.05). Also, on multivariate analysis, HNM location versus other anatomic sites was independently predictive of decreased DFS and OS (
P
< 0.001). By Kaplan-Meier analysis, HNM was associated significantly with the worst DFS and OS.
Conclusions
Primary melanoma anatomic location is an independent predictor of SLN status and survival. Although HNM has a decreased SLN-positivity rate, it shows a significantly increased risk of recurrence and death as compared with other sites.]]></description><subject>Clinical outcomes</subject><subject>Extremities - pathology</subject><subject>Extremities - surgery</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Head and Neck Neoplasms - mortality</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Head and Neck Neoplasms - surgery</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Melanoma - mortality</subject><subject>Melanoma - pathology</subject><subject>Melanoma - surgery</subject><subject>Melanomas</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Prognosis</subject><subject>Sentinel Lymph Node Biopsy</subject><subject>Skin Neoplasms - mortality</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - surgery</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival Rate</subject><subject>Tertiary Care Centers</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kctO3DAUhi1UxP0BuqksddNNim-x41VVTaEgDSBxWVtOfFICSTzYjtp5Al4bDwOoQmJly-f7_3OOf4Q-U_KdMlEeRkoEFwWhvGBaqUJtoB1a5hchK_op34msCs1kuY12Y7wjhCpOyi20zbgUWnOygx5PIz4B67AdHT6H5h6fQW9HP1j8q2tbCDAm3AY_4OswjffP2NG_FGDo0vKNjfhvl27xJcQFNAknj6-yrhuhx_PlsLjF594Bvko2TfHZYtZ3Y9fYHl9MqfED_NhHm63tIxy8nHvo5vjoenZSzC9-n85-zouGK5aKUtaOKSuEa0vGhK15bXVjueRKV7YkXDqnnMxES8pWag4VAc0rVWtrq_xRe-jb2ncR_MMEMZmhiw30eQ_wUzRU0IoKzhjJ6Nd36J2fwpinW1FKEKorkSm6pprgYwzQmkXoBhuWhhKzSsmsUzK5uVmlZFTWfHlxnuoB3JviNZYMsDUQc2n8A-G_1h-6PgGcGpxz</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Fadaki, Niloofar</creator><creator>Li, Rui</creator><creator>Parrett, Brian</creator><creator>Sanders, Grant</creator><creator>Thummala, Suresh</creator><creator>Martineau, Lea</creator><creator>Cardona-Huerta, Servando</creator><creator>Miranda, Suzette</creator><creator>Cheng, Shih-Tsung</creator><creator>Miller, James R.</creator><creator>Singer, Mark</creator><creator>Cleaver, James E.</creator><creator>Kashani-Sabet, Mohammed</creator><creator>Leong, Stanley P. L.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20130901</creationdate><title>Is Head and Neck Melanoma Different from Trunk and Extremity Melanomas with Respect to Sentinel Lymph Node Status and Clinical Outcome?</title><author>Fadaki, Niloofar ; Li, Rui ; Parrett, Brian ; Sanders, Grant ; Thummala, Suresh ; Martineau, Lea ; Cardona-Huerta, Servando ; Miranda, Suzette ; Cheng, Shih-Tsung ; Miller, James R. ; Singer, Mark ; Cleaver, James E. ; Kashani-Sabet, Mohammed ; Leong, Stanley P. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-56bd27a44df5224ab3ba9ca363798a5036dd7d67a4f05f693e80e9387b9aa8013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Clinical outcomes</topic><topic>Extremities - pathology</topic><topic>Extremities - surgery</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Head and Neck Neoplasms - mortality</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Head and Neck Neoplasms - surgery</topic><topic>Humans</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Melanoma - mortality</topic><topic>Melanoma - pathology</topic><topic>Melanoma - surgery</topic><topic>Melanomas</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Prognosis</topic><topic>Sentinel Lymph Node Biopsy</topic><topic>Skin Neoplasms - mortality</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin Neoplasms - surgery</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival Rate</topic><topic>Tertiary Care Centers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fadaki, Niloofar</creatorcontrib><creatorcontrib>Li, Rui</creatorcontrib><creatorcontrib>Parrett, Brian</creatorcontrib><creatorcontrib>Sanders, Grant</creatorcontrib><creatorcontrib>Thummala, Suresh</creatorcontrib><creatorcontrib>Martineau, Lea</creatorcontrib><creatorcontrib>Cardona-Huerta, Servando</creatorcontrib><creatorcontrib>Miranda, Suzette</creatorcontrib><creatorcontrib>Cheng, Shih-Tsung</creatorcontrib><creatorcontrib>Miller, James R.</creatorcontrib><creatorcontrib>Singer, Mark</creatorcontrib><creatorcontrib>Cleaver, James E.</creatorcontrib><creatorcontrib>Kashani-Sabet, Mohammed</creatorcontrib><creatorcontrib>Leong, Stanley P. L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fadaki, Niloofar</au><au>Li, Rui</au><au>Parrett, Brian</au><au>Sanders, Grant</au><au>Thummala, Suresh</au><au>Martineau, Lea</au><au>Cardona-Huerta, Servando</au><au>Miranda, Suzette</au><au>Cheng, Shih-Tsung</au><au>Miller, James R.</au><au>Singer, Mark</au><au>Cleaver, James E.</au><au>Kashani-Sabet, Mohammed</au><au>Leong, Stanley P. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is Head and Neck Melanoma Different from Trunk and Extremity Melanomas with Respect to Sentinel Lymph Node Status and Clinical Outcome?</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>20</volume><issue>9</issue><spage>3089</spage><epage>3097</epage><pages>3089-3097</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract><![CDATA[Background
Previous studies showed conflicting and inconsistent results regarding the effect of anatomic location of the melanoma on sentinel lymph node (SLN) positivity and/or survival. This study was conducted to evaluate and compare the effect of the anatomic locations of primary melanoma on long-term clinical outcomes.
Methods
All consecutive cutaneous melanoma patients (
n
= 2,079) who underwent selective SLN dissection (SLND) from 1993 to 2009 in a single academic tertiary-care medical center were included. SLN positive rate, disease-free survival (DFS), and overall survival (OS) were determined. Kaplan-Meier survival, univariate, and multivariate analyses were performed to determine predictive factors for SLN status, DFS, and OS.
Results
Head and neck melanoma (HNM) had the lowest SLN-positive rate at 10.8 % (16.8 % for extremity and 19.3 % for trunk;
P
= 0.002) but had the worst 5-year DFS (
P
< 0.0001) and 5-year OS (
P
< 0.0001) compared with other sites. Tumor thickness (
P
< 0.001), ulceration (
P
< 0.001), HNM location (
P
= 0.001), mitotic rate (
P
< 0.001), and decreasing age (
P
< 0.001) were independent predictive factors for SLN-positivity. HNM with T3 or T4 thickness had significantly lower SLN positive rate compared with other locations (
P
≤ 0.05). Also, on multivariate analysis, HNM location versus other anatomic sites was independently predictive of decreased DFS and OS (
P
< 0.001). By Kaplan-Meier analysis, HNM was associated significantly with the worst DFS and OS.
Conclusions
Primary melanoma anatomic location is an independent predictor of SLN status and survival. Although HNM has a decreased SLN-positivity rate, it shows a significantly increased risk of recurrence and death as compared with other sites.]]></abstract><cop>Boston</cop><pub>Springer US</pub><pmid>23649930</pmid><doi>10.1245/s10434-013-2977-7</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2013-09, Vol.20 (9), p.3089-3097 |
| issn | 1068-9265 1534-4681 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1418143220 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Clinical outcomes Extremities - pathology Extremities - surgery Female Follow-Up Studies Head and Neck Neoplasms - mortality Head and Neck Neoplasms - pathology Head and Neck Neoplasms - surgery Humans Lymphatic Metastasis Male Medicine Medicine & Public Health Melanoma - mortality Melanoma - pathology Melanoma - surgery Melanomas Middle Aged Neoplasm Staging Oncology Prognosis Sentinel Lymph Node Biopsy Skin Neoplasms - mortality Skin Neoplasms - pathology Skin Neoplasms - surgery Surgery Surgical Oncology Survival Rate Tertiary Care Centers |
| title | Is Head and Neck Melanoma Different from Trunk and Extremity Melanomas with Respect to Sentinel Lymph Node Status and Clinical Outcome? |
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