Synthesis and release of the bacterial compatible solute 5-hydroxyectoine in Hansenula polymorpha

► Hansenula polymorpha was engineered to express the enzymes of the Halomonas elongata derived 5-hydroxyectoine biosynthesis pathway. ► Expression of EctB, EctA, EctC and EctD in H. polymorpha led to production of 5-hydroxyectoine in gram per liter scale. ► 5-Hydroxyectoine synthesis was influenced...

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Veröffentlicht in:	Journal of biotechnology 2013-08, Vol.167 (2), p.85-93
Hauptverfasser:	Eilert, Eva, Kranz, Andreas, Hollenberg, Cornelis P., Piontek, Michael, Suckow, Manfred
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Hydroxyectoine Amino Acids, Diamino - biosynthesis Amino Acids, Diamino - genetics Amino Acids, Diamino - metabolism Bacterial Proteins - biosynthesis Bacterial Proteins - genetics Bacterial Proteins - metabolism biosynthesis biotechnology Carbon - metabolism Compatible solute Ectoine enzymes genes Genes, Bacterial Halomonas - genetics Halomonas - metabolism Halomonas elongata Hansenula polymorpha heat Hydrogen-Ion Concentration osmotic stress Pichia - genetics Pichia - metabolism Salinity solutes turgor Whole-cell biocatalysis
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