Synthesis of protected racemic β,γ-unsaturated-α-amino acids via γ-phenylseleno-α,β-unsaturated esters

Synthesis of protected racemic β,γ-unsaturated-α-amino acids via γ-phenylseleno-α,β-unsaturated esters

Oxidative rearrangement of γ-phenylseleno-α,β-unsaturated esters ( 1 ) with the N-chlorosuccinimide/N,N-diisopropylethylamine/alkyl carbamate reagent combination affords preparatively useful yields of protected β,γ-unsaturated-α-amino acids ( 2 ).

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Bibliographische Detailangaben
Veröffentlicht in:Tetrahedron letters 1985, Vol.26 (16), p.1959-1962
Hauptverfasser: Fitzner, Jeffrey N., Pratt, Daniel V., Hopkins, Paul B.
Format: Artikel
Sprache:eng
Schlagworte:
Aliphatic compounds
alpha -amino acids
Chemistry
Exact sciences and technology
Organic chemistry
Preparations and properties
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Zusammenfassung:Oxidative rearrangement of γ-phenylseleno-α,β-unsaturated esters ( 1 ) with the N-chlorosuccinimide/N,N-diisopropylethylamine/alkyl carbamate reagent combination affords preparatively useful yields of protected β,γ-unsaturated-α-amino acids ( 2 ).
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)98351-5