Assessing how electroporation affects the effective conductivity tensor of biological tissues

We report calculations of the anisotropy ratio of the electrical conductivity of a simple model of a loose connective biological tissue described as a random assembly of multiscale undeformable core-shell and controlled polydisperse spherical structures. One can estimate a 10% increase in the anisotropy ratio due to the application of electric field (duration 100 mu m) above the electroporation threshold (40 kV m-1) up to 120 kV m-1. These findings are consistent with the experimental data on the field-induced anisotropy dependence of the electrical conductivity due to cell membrane electroporation.